Biomarker News and Research

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A biomarker is a biological molecule found in blood, other body fluids, or tissues that is a sign of a normal or abnormal process, or of a condition or disease. A biomarker may be used to see how well the body responds to a treatment for a disease or condition. Also called molecular marker and signature molecule.

Researchers discover a highly potent biomarker for clinical response to CAR-T cell therapy

A MedUni Vienna research team has discovered a highly potent biomarker for clinical response to CAR-T cell therapy, describing the prerequisites for optimal use of this novel therapy for lymphoma treatment.

9 Jan 2023

Clinically relevant biomarker strategies in drug development

In this interview, NewsMedical speaks with Dr. Justin Devine and Dr. Nicholas Woudberg about biomarkers, their importance for drug development as well as the potential they have when it comes to machine learning.

From Synexa Life Sciences 9 Jan 2023

Intense exercise encourages coronary artery calcification

A recent Circulation journal paper has focused on investigating the relationship between exercise volume and intensity and the progression of coronary atherosclerosis in middle-aged and older male athletes.

5 Jan 2023

A gloomy outlook for type 1 diabetes in children and adolescents by 2050

A study published in The Lancet Diabetes and Endocrinology journal estimates the global incidence of type 1 diabetes in children and adolescents using microsimulation models.

5 Jan 2023

Immune system B-cells may be better in predicting HER2-positive breast cancer treatment response

Researchers at UNC Lineberger Comprehensive Cancer Center and colleagues have found that measuring activation of immune-system B cells may be better than measuring either T-cell activation or the total number of immune cells in and around a tumor, called tumor-infiltrating lymphocytes (TILs), in predicting whether HER2-positive breast cancer responds to treatment.

5 Jan 2023

Insulin-like peptide 3 may be a predictor of hypogonadism and age-associated morbidity in older males

Researchers evaluated whether insulin-like peptide 3 (INSL3) could predict hypogonadism and age-associated morbidity in older males.

3 Jan 2023

DNAm measures of biological aging linked with neuropsychologically-validated cognitive decline in midlife

A new research paper was published in Aging (listed as "Aging (Albany NY)" by MEDLINE/PubMed and "Aging-US" by Web of Science) Volume 14, Issue 23, entitled, "DNA methylation-based measures of biological aging and cognitive decline over 16-years: preliminary longitudinal findings in midlife."

30 Dec 2022

New test detects biomarker of Alzheimer's disease neurodegeneration in blood samples

A group of neuroscientists led by a University of Pittsburgh School of Medicine researcher developed a test to detect a novel marker of Alzheimer's disease neurodegeneration in a blood sample. A study on their results was published today in Brain.

28 Dec 2022

Researchers discover a protein linked with the onset of anthracycline-associated cardiac toxicity

Anthracyclines are a class of chemotherapies effective in treating many forms of cancer, including leukemias, lymphomas and breast cancer.

27 Dec 2022

Discovery could pave the way for developing therapies to treat nonalcoholic steatohepatitis

UT Southwestern immunologists have uncovered a key pathogenic event prompted by obesity that can trigger severe forms of nonalcoholic fatty liver disease and potential liver failure.

27 Dec 2022

Plasma GH is a biomarker candidate for predicting outcomes in advanced HCC patients treated with Atezo/Bev

A new research paper was published in Oncotarget's Volume 13 on December 6, 2022, entitled, "Plasma growth hormone is a potential biomarker of response to atezolizumab and bevacizumab in advanced hepatocellular carcinoma patients."

22 Dec 2022

Impact of epigenetics on the clinical management of cancer patients

Dr. Manel Esteller and Dr. Verónica Dávalos, researchers at the Josep Carreras Leukaemia Research Institute, describe in a new article the impact of epigenetics on cancer treatment and how it has become a crucial tool to improve early detection, predict disease progression and become a target for new treatments.

22 Dec 2022

Brief roundup of research done by experts at UCLA Health

Below is a brief roundup of news and story ideas from the experts at UCLA Health.

21 Dec 2022

Researchers devise new biomarker-based strategy to screen for myocarditis caused by cancer treatment

Researchers at Michigan Medicine have devised a new biomarker-based strategy to screen for a rare and deadly complication caused by monoclonal antibodies used to treat several cancers.

20 Dec 2022

Study identifies a neuromarker for drug and food craving

Craving is known to be a key factor in substance use disorders and can increase the likelihood of future drug use or relapse. Yet its neural basis - or, how the brain gives rise to craving - is not well understood.

19 Dec 2022

Low ET levels in blood plasma may predict increased risk of cognitive impairment, dementia

A recent study by a team comprising researchers from the National University of Singapore and the National University Health System revealed that low levels of ergothioneine in blood plasma may predict an increased risk of cognitive impairment and dementia, suggesting possible therapeutic or early screening measures for cognitive impairment and dementia in the elderly.

19 Dec 2022

Origins of the serious cancer-like disease LCH discovered

The origins of the serious cancer-like disease LCH have been identified by researchers from Karolinska Institutet in collaboration with Karolinska University Hospital. The findings presented in Science Immunology may lead to new, targeted treatments.

16 Dec 2022

Study to determine if a DNA-based blood test can help detect cancer predisposition in NF1 patients

The Children’s Tumor Foundation (CTF) has announced a groundbreaking 3-year study, which it will fund for nearly $2 million, to determine if a DNA-based blood test can offer better understanding and ultimately earlier diagnosis of cancer predisposition in neurofibromatosis type 1 (NF1) patients.

16 Dec 2022

Common type 2 diabetes drug requires the presence of GDF15 cytokine to present antidiabetic effects

Metformin, the most prescribed drug for treating diabetes mellitus, known as type 2 diabetes, requires the presence of the growth differentiation factor 15 (GDF15) —a protein whose expression increases in response to cellular stress— to present its antidiabetic effects.

16 Dec 2022

Researchers identify a new target gene in pancreatic ductal adenocarcinoma

Pancreatic cancer remains one of the deadliest malignancies worldwide. Since five-year survival rate for pancreatic ductal adenocarcinoma (PDAC) is only about 3% in patients, PDAC is very difficult to treat with surgery worldwide.

16 Dec 2022

Biomarker News and Research

Further Reading

Researchers discover a highly potent biomarker for clinical response to CAR-T cell therapy

Clinically relevant biomarker strategies in drug development

Intense exercise encourages coronary artery calcification

A gloomy outlook for type 1 diabetes in children and adolescents by 2050

Immune system B-cells may be better in predicting HER2-positive breast cancer treatment response

Insulin-like peptide 3 may be a predictor of hypogonadism and age-associated morbidity in older males

DNAm measures of biological aging linked with neuropsychologically-validated cognitive decline in midlife

New test detects biomarker of Alzheimer's disease neurodegeneration in blood samples

Researchers discover a protein linked with the onset of anthracycline-associated cardiac toxicity

Discovery could pave the way for developing therapies to treat nonalcoholic steatohepatitis

Plasma GH is a biomarker candidate for predicting outcomes in advanced HCC patients treated with Atezo/Bev

Impact of epigenetics on the clinical management of cancer patients

Brief roundup of research done by experts at UCLA Health

Researchers devise new biomarker-based strategy to screen for myocarditis caused by cancer treatment

Study identifies a neuromarker for drug and food craving

Low ET levels in blood plasma may predict increased risk of cognitive impairment, dementia

Origins of the serious cancer-like disease LCH discovered

Study to determine if a DNA-based blood test can help detect cancer predisposition in NF1 patients

Common type 2 diabetes drug requires the presence of GDF15 cytokine to present antidiabetic effects

Researchers identify a new target gene in pancreatic ductal adenocarcinoma

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