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Novel intermediate form of serotonin receptor identified as therapeutic target for psychiatric disorders

Misha Kudryshev's lab at the Max Delbrück Center has identified a molecular intermediate of a serotonin receptor that is involved in diseases such as depression and schizophrenia.

4 Sep 2024

A novel therapeutic option for HER2-positive extramammary Paget disease

The research article presents a comprehensive evaluation of the human epidermal growth factor receptor 2 (HER2) status in extramammary Paget disease (EMPD) and explores the therapeutic potential of disitamab vedotin (DV), a novel humanized anti-HER2 antibody-drug conjugate (ADC), for this rare adenocarcinoma.

4 Sep 2024

Mineralocorticoid receptor antagonists reduce risk of cardiovascular events in patients with heart failure

MRAs significantly lower the risk of cardiovascular death and HF hospitalization in heart failure patients.

3 Sep 2024

European Society of Cardiology highlights underrecognized link between obesity and heart disease

Obesity is a key factor in cardiovascular disease, prompting the ESC to recommend comprehensive strategies for prevention and management to reduce health risks.

3 Sep 2024

$FINEARTS-HF trial shows finerenone benefits for heart failure with preserved ejection fraction$

FINEARTS-HF trial shows finerenone benefits for heart failure with preserved ejection fraction

Finerenone reduced heart failure (HF) events and cardiovascular death in patients with HF and mildly reduced (HFmrEF) or preserved ejection fraction (HFpEF), according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

2 Sep 2024

Pooled analysis shows finerenone reduces all-cause mortality but not cardiovascular death

A pooled analysis of three large trials failed to demonstrate significant reductions in cardiovascular death with finerenone, but significantly lower all-cause mortality, cardiovascular events and kidney outcomes were observed, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

2 Sep 2024

Early viral activity plays critical role in long COVID, study suggests

Findings on early viral and immune markers provide insights into the pathogenesis of post-acute sequelae of SARS-CoV-2, informing future research and therapies.

2 Sep 2024

$Mineralocorticoid receptor antagonists benefit heart failure patients across ejection fractions$

Mineralocorticoid receptor antagonists benefit heart failure patients across ejection fractions

Mineralocorticoid receptor antagonists (MRAs) reduced the risk of cardiovascular death or heart failure (HF) hospitalization in patients with HF and reduced ejection fraction (HFrEF) and also in those with mildly reduced or preserved ejection fraction (HFmrEF/HFpEF), according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

2 Sep 2024

New method revolutionizes DNA-encoded chemical libraries

Nowadays, there's lots of buzz about spectacular new medical treatments such as personalised cancer therapy with modified immune cells or antibodies.

2 Sep 2024

$Finerenone shows promise for heart failure with mildly reduced or preserved ejection fraction$

Finerenone shows promise for heart failure with mildly reduced or preserved ejection fraction

Finerenone reduced the composite of total first and recurrent heart failure (HF) events (hospitalizations for HF or urgent HF visits) and cardiovascular death in patients with HF and mildly reduced or preserved ejection fraction, according to an international clinical trial led by investigators from Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system.

2 Sep 2024

Is semaglutide use during breastfeeding safe?

Researchers found no detectable levels of semaglutide in breast milk, suggesting minimal risk to breastfed infants, but highlighted the need for monitoring maternal nutrition and milk production.

2 Sep 2024

NCCS study uses exosomes to overcome resistance to epidermal growth factor receptor inhibitors

In a new study, clinician-scientists and researchers from the National Cancer Centre Singapore (NCCS) have demonstrated the use of exosomes to successfully target squamous cell cancer tumours that are usually resistant to epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs). Their research is the first where exosomes have been applied to target TKI-resistant cancers in Singapore. The findings were published in the journal Developmental Cell last month.

2 Sep 2024

Rising resting heart rate over the years linked to shorter lifespan, study show

Study finds that increases in resting heart rate over time significantly raise mortality risk, underscoring heart rate as a key factor in lifespan determination.

1 Sep 2024

Intranasal vaccine shows broad SARS-CoV-2 variant protection

Study demonstrates that a single-dose intranasal live-attenuated vaccine, CDO-7N-1, provides broad protection against SARS-CoV-2 and its variants by inducing potent immune responses, including neutralizing antibodies and T-cell activity, in animal models.

1 Sep 2024

Major surgery complications unaffected by use of renin-angiotensin system inhibitors

There was no difference in major post-operative complications in patients who continued vs. stopped renin-angiotensin system inhibitors (RASIs) before non-cardiac surgery, according to late-breaking research presented in a Hot Line session today at ESC Congress 2024.

30 Aug 2024

Receptor News and Research

Novel intermediate form of serotonin receptor identified as therapeutic target for psychiatric disorders

A novel therapeutic option for HER2-positive extramammary Paget disease

Mineralocorticoid receptor antagonists reduce risk of cardiovascular events in patients with heart failure

European Society of Cardiology highlights underrecognized link between obesity and heart disease

FINEARTS-HF trial shows finerenone benefits for heart failure with preserved ejection fraction

Pooled analysis shows finerenone reduces all-cause mortality but not cardiovascular death

Early viral activity plays critical role in long COVID, study suggests

Mineralocorticoid receptor antagonists benefit heart failure patients across ejection fractions

New method revolutionizes DNA-encoded chemical libraries

Finerenone shows promise for heart failure with mildly reduced or preserved ejection fraction

Is semaglutide use during breastfeeding safe?

NCCS study uses exosomes to overcome resistance to epidermal growth factor receptor inhibitors

Rising resting heart rate over the years linked to shorter lifespan, study show

Intranasal vaccine shows broad SARS-CoV-2 variant protection

Major surgery complications unaffected by use of renin-angiotensin system inhibitors

First-generation antihistamine drugs could increase seizure risk among young children

The Arctic Sea revealed as a potential treasure trove for new medicines

Fibrin fuels thromboinflammation and brain damage in COVID-19

Acute kidney injury doubles dementia risk, study finds

Exploring the role of suvorexant in reducing delirium among older adults

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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