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STE90-C11, a SARS-CoV-2 neutralizing antibody, shows high inhibition of RBD-ACE2 binding

In a new study, researchers describe the identification of a neutralizing antibody that binds to the RBD at the same site as the human host cell receptor.

7 Dec 2020

Novel modular design approach to antibody nanocage generation

A new study shows the benefits of using computational design to create antibody nanocages that have the required orientation.

7 Dec 2020

Researchers identify new target that may lead to novel treatment for Alzheimer’s disease

Researchers at the Case Western Reserve University School of Medicine have identified a new target in development of Alzheimer's disease (AD) that could lead to therapies focused on treating the neurodegenerative condition early in its progression.

7 Dec 2020

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

Clinical investigators from Hackensack Meridian Health John Theurer Cancer Center (JTCC), a member of the Georgetown Lombardi Comprehensive Cancer Center consortium, are to present updates on treatment advances in multiple myeloma (MM), mantle cell lymphoma (MCL), and other types of B-cell lymphoma (BCL) as well as leukemia at the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, to be held virtually from December 5-8, 2020.

7 Dec 2020

Combination of venetoclax and standard therapies shows promise in high-risk myeloid blood cancers

The novel oral drug venetoclax can be safely added to standard therapies for some high-risk myeloid blood cancers and in early studies the combination shows promise of improved outcomes, say scientists from Dana-Farber Cancer Institute.

7 Dec 2020

Clonal hematopoiesis can confer a health benefit in allogeneic transplants

Clonal hematopoiesis (CH) is a recently identified condition in which mutations associated with blood cancers are detected in the blood of some healthy, usually older, individuals who don't have cancer.

7 Dec 2020

Researchers identify potential drug combination to treat uveal melanoma

Researchers at Huntsman Cancer Institute (HCI) at the University of Utah (U of U) have identified a potential drug combination to treat uveal melanoma, a type of eye cancer.

7 Dec 2020

Study identifies multiple important genomic differences in BCL malignancies using genomic ancestry

B-cell lymphoma and leukemias (BCL) are a diverse set of malignancies. While the genomic landscape of many BCL subtypes has been described, genomic ancestry has rarely been explored.

6 Dec 2020

Study: CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

A CAR T-cell therapy known as axicabtagene ciloleucel (axi-cel) drove cancer cells to undetectable levels in nearly 80% of patients with advanced non-Hodgkin lymphoma (NHL) in a phase 2 clinical trial.

6 Dec 2020

Free radicals may be important for the brain to remain adaptable

Reactive oxygen molecules, also known as "free radicals", are generally considered harmful. However as it now turns out, they control cellular processes, which are important for the brain's ability to adapt - at least in mice.

5 Dec 2020

Donor stem cell transplant can improve survival rates for older patients with MDS, study shows

A new clinical trial offers the most compelling evidence to date that a donor stem cell transplant can improve survival rates for older patients with higher-risk myelodysplastic syndrome (MDS), Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology Annual Meeting.

5 Dec 2020

CRISPR-based test could provide rapid, low-cost testing to help control COVID-19 spread

Imagine swabbing your nostrils, putting the swab in a device, and getting a read-out on your phone in 15 to 30 minutes that tells you if you are infected with the COVID-19 virus.

5 Dec 2020

Researchers develop wound-healing gel based on a substance produced by Trichoderma fungi

Researchers from the Department of Biochemistry of RUDN University developed a wound-healing gel based on a substance that is produced by Trichoderma fungi.

5 Dec 2020

Mysterious particle found in the blood of people with sepsis

Researchers at La Jolla Institute for Immunology have found that people with sepsis have never-before-seen particles in their blood.

5 Dec 2020

Rice biochemist discovers hidden structure in essential metabolic machinery

In his first year of graduate school, Rice University biochemist Zachary Wright discovered something hidden inside a common piece of cellular machinery that's essential for all higher order life from yeast to humans.

5 Dec 2020

Matrix-induced autologous chondrocyte implantation shows comparable benefit to therapy alternatives

Autologous chondrocyte implantation (ACI) has been used in adults with deep cartilage defects for over 30 years and has been further developed and modified over time.

5 Dec 2020

Findings about primary cilia may be relevant for transplantation therapies in diabetes

A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells in the pancreatic islets.

5 Dec 2020

Biochemical cascade in the brain leads to the destruction of synapses in Alzheimer's

A new study on Alzheimer's disease by Scripps Research scientists has revealed a previously unknown biochemical cascade in the brain that leads to the destruction of synapses, the connections between nerve cells that are responsible for memory and cognition.

5 Dec 2020

β-AR agonist therapy may prevent metastasis in oral squamous cell carcinoma

Affecting almost 600,000 people worldwide every year, and with only a 50% survival rate, oral squamous cell carcinoma (OSCC) is one of the more common and deadly forms of cancer.

4 Dec 2020

Exhaled breath can aid in the diagnosis of cancer

The air we exhale contains information that can assist with the diagnosis of disease. Researchers at the Fraunhofer Project Hub for Microelectronic and Optical Systems for Biomedicine MEOS are now developing solutions designed to enable the analysis of breath gas for this purpose. Although their research focuses on the early detection of cancer, the same principle could also be applied to distinguish between COVID-19 and other respiratory diseases.

4 Dec 2020

B Cell News and Research

STE90-C11, a SARS-CoV-2 neutralizing antibody, shows high inhibition of RBD-ACE2 binding

Novel modular design approach to antibody nanocage generation

Researchers identify new target that may lead to novel treatment for Alzheimer’s disease

Clinical investigators present abstracts on hematological malignancies at ASH Annual Meeting and Exposition

Combination of venetoclax and standard therapies shows promise in high-risk myeloid blood cancers

Clonal hematopoiesis can confer a health benefit in allogeneic transplants

Researchers identify potential drug combination to treat uveal melanoma

Study identifies multiple important genomic differences in BCL malignancies using genomic ancestry

Study: CAR T-cell therapy reduced cancer cells in patients with advanced non-Hodgkin lymphoma

Free radicals may be important for the brain to remain adaptable

Donor stem cell transplant can improve survival rates for older patients with MDS, study shows

CRISPR-based test could provide rapid, low-cost testing to help control COVID-19 spread

Researchers develop wound-healing gel based on a substance produced by Trichoderma fungi

Mysterious particle found in the blood of people with sepsis

Rice biochemist discovers hidden structure in essential metabolic machinery

Matrix-induced autologous chondrocyte implantation shows comparable benefit to therapy alternatives

Findings about primary cilia may be relevant for transplantation therapies in diabetes

Biochemical cascade in the brain leads to the destruction of synapses in Alzheimer's

β-AR agonist therapy may prevent metastasis in oral squamous cell carcinoma

Exhaled breath can aid in the diagnosis of cancer

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