Animal Model News and Research

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Researchers discover drug that halts growth of brain tumor cells

Working with mice, Johns Hopkins researchers have discovered that weeks of treatment with a repurposed FDA-approved drug halted the growth of - and ultimately left no detectable trace of - brain tumor cells taken from adult human patients.

24 Sep 2013

Lpath receives NIH SBIR grant to investigate effect of Lpathomab compound on diabetic neuropathy

Lpath, Inc., the industry leader in lipidomics-based therapeutics, announced receipt of a Notice of Grant Award from the National Institutes of Health (NIH). This $145,000 Phase 1 SBIR grant will support the study of Lpath's therapeutic monoclonal antibody, Lpathomab™, in animal models of diabetic neuropathic pain and diabetic neuropathy.

23 Sep 2013

Research discovery suggests whole new frontier in human and animal brain functioning

Researchers from the University of Montreal and their colleagues have found brain activity beyond a flat line EEG, which they have called Nu-complexes (from the Greek letter).

19 Sep 2013

Scientists develop experimental vaccine against human CMV infection

An experimental vaccine against human cytomegalovirus (CMV) infection, which endangers the developing fetus, organ transplant recipients, patients with HIV and others who have a weakened immune system, proved safe and more effective than previous vaccines developed to prevent infection by the ubiquitous virus.

19 Sep 2013

Researchers develop brown fat detection method to combat obesity

When it comes to fat, you want the brown type and not so much of the white variety because brown fat burns energy to keep you warm and metabolically active, while white fat stores excess energy around your waist, causing health problems. Researchers at The University of Texas Health Science Center at Houston Medical School are studying brown fat with a goal of fighting obesity.

19 Sep 2013

New technique provides better understanding of factors causing Smith-Lemli-Opitz Syndrome

The first proteomic analysis of an animal model of a rare, sometimes deadly birth defect, Smith-Lemli-Opitz Syndrome (SLOS), has revealed that the molecular mechanisms that cause it are more complex than previously understood.

12 Sep 2013

Researchers develop TSUNAMI method to create animal model of adult-onset version of SMA

A research team at Cold Spring Harbor Laboratory has used a recently developed technology they call TSUNAMI to create the first animal model of the adult-onset version of spinal muscular atrophy, a devastating motor-neuron illness.

10 Sep 2013

Little STING could go long way in avoiding arthritis, type 1 diabetes, report researchers

A little STING could go a long way in helping treat or even avoid autoimmune diseases such as arthritis, type 1 diabetes and multiple sclerosis, researchers report.

10 Sep 2013

One-time treatment slows onset and progression of ALS, study finds

Studies of a therapy designed to treat amyotrophic lateral sclerosis suggest that the treatment dramatically slows onset and progression of the deadly disease, one of the most common neuromuscular disorders in the world.

10 Sep 2013

Amino acid arginine improves treatment for type 2 diabetes

More than 371 million people worldwide suffer from diabetes, of whom 90% are affected by lifestyle-related diabetes mellitus type 2 (type 2 diabetes).

10 Sep 2013

Locus coeruleus plays major role in learning, memory and other cognitive functions

Death of neurons in the dorsal raphe nucleus and locus coeruleus is a pathological characteristic of the disease. Previous studies concerning the pathological characteristic of Alzheimer's disease mainly focus on learning and memory-related hippocampus, and less attention has been paid to the locus coeruleus.

6 Sep 2013

Chronic granulomatous disease (CGD) research: an interview with Dr. Griffin Rodgers, NIDDK director

Chronic granulomatous disease, or CGD, is a diverse group of inherited diseases in which certain cells of the immune system have difficulty forming reactive oxygen compounds, most importantly superoxide radicals. These are used by these white blood cells to kill certain bacteria.

3 Sep 2013

Researchers develop first animal model simulating eye complications linked with Graves' disease

Researchers have developed the first animal model simulating the eye complications associated with the thyroid condition Graves' disease, a breakthrough that could pave the way for better treatments, according to a recent study accepted for publication in The Endocrine Society's journal Endocrinology.

3 Sep 2013

Findings establish gene as critical regulator of lung cancer tumor growth

Scientists from the Florida campus of The Scripps Research Institute (TSRI) have shown that a well-known cancer-causing gene implicated in a number of malignancies plays a far more critical role in non-small cell lung cancer, the most common form of the disease, than previously thought.

30 Aug 2013

Study points to potential new therapeutic target for preventing birth defects in women with diabetes

A research team at the University of Maryland School of Medicine has identified a cell signaling pathway which plays a significant role in causing developmental defects of the fetal spinal cord and brain in babies of women with diabetes.

29 Aug 2013

Research finding could lead to potential treatment for lymphedema

The molecule interleukin-7 is an important immune messenger protein which ensures that a sufficient number of T cells are present in our body for immune defence. Researchers from ETH Zurich have now demonstrated that IL-7 has another important function: it enhances the drainage function of lymphatic vessels, which collect fluid that has leaked out of blood vessels into the body tissue and return it to the bloodstream.

27 Aug 2013

Drug to treat blood cancers may also stop spread of invasive breast cancer

A drug used to treat blood cancers may also stop the spread of invasive breast cancer, researchers at Mayo Clinic in Florida have discovered. Their study, published online in Breast Cancer Research, found that in the lab and in animals, the drug decitabine turns on a gene coding for protein kinase D1 (PRKD1) that halts the ability of cancer cells to separate from a tumor and spread to distant organs.

23 Aug 2013

Scientists identify molecular mechanism that contributes to pancreatic cancer

New research led by scientists at The University of Texas Health Science Center at Houston (UTHealth) and Baylor College of Medicine could aid efforts to diagnose and treat one of the most lethal and hard-to-treat types of cancer.

23 Aug 2013

Psychogenics Picks Up Alzheimer’s Animal Model From USF

PsychoGenics obtained an exclusive license from the University of South Florida to its APP/PS1 double transgenic mice, which co-express the M146L presenilin 1 (PS1) mutation and the double mutations at K670N/M671L (Swedish mutation) in the amyloid precursor protein (APP).

22 Aug 2013

Study shows superantigens produced by staph bacteria cause infective endocarditis and sepsis

University of Iowa researchers have discovered what causes the lethal effects of staphylococcal infective endocarditis - a serious bacterial infection of heart valves that kills approximately 20,000 Americans each year.

20 Aug 2013

Animal Model News and Research

Researchers discover drug that halts growth of brain tumor cells

Lpath receives NIH SBIR grant to investigate effect of Lpathomab compound on diabetic neuropathy

Research discovery suggests whole new frontier in human and animal brain functioning

Scientists develop experimental vaccine against human CMV infection

Researchers develop brown fat detection method to combat obesity

New technique provides better understanding of factors causing Smith-Lemli-Opitz Syndrome

Researchers develop TSUNAMI method to create animal model of adult-onset version of SMA

Little STING could go long way in avoiding arthritis, type 1 diabetes, report researchers

One-time treatment slows onset and progression of ALS, study finds

Amino acid arginine improves treatment for type 2 diabetes

Locus coeruleus plays major role in learning, memory and other cognitive functions

Chronic granulomatous disease (CGD) research: an interview with Dr. Griffin Rodgers, NIDDK director

Researchers develop first animal model simulating eye complications linked with Graves' disease

Findings establish gene as critical regulator of lung cancer tumor growth

Study points to potential new therapeutic target for preventing birth defects in women with diabetes

Research finding could lead to potential treatment for lymphedema

Drug to treat blood cancers may also stop spread of invasive breast cancer

Scientists identify molecular mechanism that contributes to pancreatic cancer

Psychogenics Picks Up Alzheimer’s Animal Model From USF

Study shows superantigens produced by staph bacteria cause infective endocarditis and sepsis

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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