Clinical Trial News and Research

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Researchers discover effective treatment strategy for lethal glioblastoma

Glioblastoma (GBM) is the most lethal brain tumor, with a median survival rate of merely 12-16 months after diagnosis. Despite surgical, radiation and chemotherapy treatments, the two-year survival rate for GBM patients is less than 10%.

7 Oct 2024

Less is more in octreotide therapy for esophageal variceal hemorrhage

Researchers at the Medical University of South Carolina revealed the need to clarify current treatment guidelines for octreotide therapy following an esophageal variceal hemorrhage in a recent study from the American Journal of Medical Sciences.

7 Oct 2024

New insights on 5-fluorouracil's mechanism in different cancers

Study reveals the drug, 5-fluorouracil, acts differently in different types of cancer — a finding that could help researchers design better drug combinations.

7 Oct 2024

Early blood test can predict treatment response and survival prospects in metastatic prostate cancer

A blood test, performed when metastatic prostate cancer is first diagnosed, can predict which patients are likely to respond to treatment and survive the longest.

7 Oct 2024

One-dose HPV vaccination could eliminate cervical cancer in Canada

Canadian vaccination programs could switch to a 1-dose gender-neutral human papillomavirus (HPV) vaccination approach and eliminate cervical cancer, suggests new modeling in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.240787.

7 Oct 2024

Researchers reveal mechanisms of how CDK12 alterations drive prostate cancer development

When researchers at the University of Michigan Rogel Cancer Center first identified a new subtype of aggressive prostate cancer, they knew they needed to understand how this genetic alteration was driving cancer and how to target it with treatment.

4 Oct 2024

New drug could extend the lives of breast cancer patients

LMU researchers have successfully tested a new drug which can significantly extend the lives of breast cancer patients.

4 Oct 2024

Collaborative study investigates underlying cause of neuropsychiatric symptoms in Parkinson's disease

Parkinson's disease is most known for its movement-related symptoms: tremors and rigidity, slowness and falls, caused by the loss of the brain's dopamine-producing neurons.

4 Oct 2024

New strategy uses bacteriophages to combat drug-resistant infections

Researchers have a new battle tactic to fight drug-resistant bacterial infections. Their strategy involves using collections of bacteriophages, viruses that naturally attack bacteria.

4 Oct 2024

Imagery rescripting offers new hope for treating hoarding disorder

Rehearsing alternative outcomes of discarding through imagery rescripting shows promise as a treatment strategy for people who hoard, a study by UNSW psychology researchers has shown.

4 Oct 2024

Thousands could have been saved during the pandemic with expanded use of convalescent plasma

A new study led by researchers at Johns Hopkins Bloomberg School of Public Health estimates that thousands of lives could have been saved during the first year of the COVID-19 pandemic if convalescent plasma had been used more broadly, particularly in outpatients at high risk for severe disease and in hospitalized patients during their first few days of admission.

4 Oct 2024

Study highlights benefits and risks of doxy-PEP for STI prevention

Taking a dose of the oral antibiotic doxycycline after a high-risk sexual encounter has dramatically reduced the incidence of sexually transmitted infections (STIs) in places where the strategy is being tried.

4 Oct 2024

International experts to gather for ALS symposium in Chicago

The 2024 Les Turner Symposium on ALS will be held on Monday, Nov. 4 in Chicago. Hosted by the Les Turner ALS Foundation and the Les Turner ALS Center at Northwestern Medicine, this event will assemble internationally-renowned ALS researchers, clinicians, advocates, and people living with ALS to discuss the latest research and perspectives on the disease.

3 Oct 2024

Non-invasive imaging technique can accurately detect clear-cell renal cell carcinoma

A new study led by investigators from the UCLA Health Jonsson Comprehensive Cancer Center has demonstrated a new, non-invasive imaging technique can accurately detect clear-cell renal cell carcinoma, the most common form of kidney cancer.

3 Oct 2024

Rice University leads development of innovative bioelectronic implant for obesity and diabetes

Rice University is part of a multiuniversity research team that has secured an award of up to $34.9 million from the Advanced Research Projects Agency for Health (ARPA-H) to accelerate the development of a bioelectronic implant designed to improve adherence for obesity and type 2 diabetes (T2D) treatment while reducing development and manufacturing costs.

3 Oct 2024

Low-dose lithium fails in long COVID trial, but higher doses show potential

A small University at Buffalo clinical trial has found that at low doses, lithium aspartate is ineffective in treating the fatigue and brain fog that is often a persistent feature of long COVID; however, a supplemental dose-finding study found some evidence that higher doses may be effective.

3 Oct 2024

Enhancing the adoption of pragmatic clinical trial results in healthcare systems

A new thought piece led by the Harvard Pilgrim Health Care Institute with collaborators from Duke University and Kaiser Permanente Washington Health Research Institute highlights the challenges facing healthcare researchers and decision makers in the quest to improve population health in a constantly evolving healthcare landscape.

3 Oct 2024

Bioelectronic 'living pharmacy' implant could transform diabetes and obesity care

A Carnegie Mellon University-led team of researchers has secured an award of up to $34.9 million from the Advanced Research Projects Agency for Health (ARPA-H).

3 Oct 2024

Implantable device revolutionizes thyroid management

A Carnegie Mellon University-led team has secured an award of up to $42 million from the Advanced Research Projects Agency for Health (ARPA-H) to accelerate the development of implantable, cell-based bioelectronic devices that deliver patient-specific therapy and monitor disease status, for conditions like hypo- and hyperthyroidism, in real time.

3 Oct 2024

SWOG S1011 trial questions the benefits of extended lymphadenectomy in bladder cancer

The SWOG S1011 randomized phase 3 trial found no significant improvement in disease-free or overall survival but a higher rate of grade 3-4 adverse events and an increased risk of death in the 90 days after surgery.

3 Oct 2024

Clinical Trial News and Research

Researchers discover effective treatment strategy for lethal glioblastoma

Less is more in octreotide therapy for esophageal variceal hemorrhage

New insights on 5-fluorouracil's mechanism in different cancers

Early blood test can predict treatment response and survival prospects in metastatic prostate cancer

One-dose HPV vaccination could eliminate cervical cancer in Canada

Researchers reveal mechanisms of how CDK12 alterations drive prostate cancer development

New drug could extend the lives of breast cancer patients

Collaborative study investigates underlying cause of neuropsychiatric symptoms in Parkinson's disease

New strategy uses bacteriophages to combat drug-resistant infections

Imagery rescripting offers new hope for treating hoarding disorder

Thousands could have been saved during the pandemic with expanded use of convalescent plasma

Study highlights benefits and risks of doxy-PEP for STI prevention

International experts to gather for ALS symposium in Chicago

Non-invasive imaging technique can accurately detect clear-cell renal cell carcinoma

Rice University leads development of innovative bioelectronic implant for obesity and diabetes

Low-dose lithium fails in long COVID trial, but higher doses show potential

Enhancing the adoption of pragmatic clinical trial results in healthcare systems

Bioelectronic 'living pharmacy' implant could transform diabetes and obesity care

Implantable device revolutionizes thyroid management

SWOG S1011 trial questions the benefits of extended lymphadenectomy in bladder cancer

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