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New immune therapy improves survival and reduces tumor burden in glioblastoma

The Wistar Institute's David B. Weiner, Ph.D. - Executive Vice President, director of the Vaccine & Immunotherapy Center and W.W. Smith Charitable Trust Distinguished Professor in Cancer Research - and his lab have successfully tested a new immune therapy that, in preclinical lab testing, reliably improves survival and reduces tumor burden in glioblastoma.

3 Dec 2024

SARS-CoV-2 spike protein found lingering in brain regions

Researchers find that SARS-CoV-2 spike protein persists in the skull-meninges-brain axis, driving neuroinflammation, neurodegeneration, and heightened vulnerability to brain injuries.

3 Dec 2024

Nanozyme breakthrough offers new hope for viral pneumonia treatment

A recent study in Nature Materials introduces an inhalable nanozyme treatment for viral pneumonia, showing promising results in reducing inflammation and viral load in various mouse models. The nanozyme, CeTA-K1tkP, demonstrates broad-spectrum effects and biocompatibility, offering a potential new approach to treating pneumonia and other inflammatory conditions.

3 Dec 2024

Scientists aim to identify the most effective TBS protocols for treating schizophrenia

Schizophrenia, which is characterized by positive symptoms (e.g., hallucinations and delusions), negative symptoms (diminished emotional expressions or avolition), and cognitive impairments (attention deficits and poor learning skills), is a serious mental health condition that affects how individuals think, behave, and perceive the world.

3 Dec 2024

Minimally invasive procedure provides relief for knee osteoarthritis sufferers

A minimally invasive procedure provides significant relief from knee pain and may prevent the need for knee replacement surgery in people with osteoarthritis, according to a study being presented this week at the annual meeting of the Radiological Society of North America (RSNA).

3 Dec 2024

Orbit Discovery and Evergreen Theragnostics expand research collaboration to advance targeted therapeutics development

Orbit Discovery, a leading provider of peptide discovery services, and Evergreen Theragnostics, a radiopharmaceutical company at the forefront of precision medicine, today announced an extension to their research collaboration to find novel targeting peptides for radiopharmaceutical delivery.

From Orbit Discovery 3 Dec 2024

Overcoming challenges in developing cell therapies for heart disease

Pathways to new treatments for heart failure take time - as long as four decades for two now accepted therapies. So, new attempts to repair scar tissue in infarcted hearts using cells or cell products need more time to develop clinical therapies that can reduce risk of death from heart failure after a heart attack.

3 Dec 2024

Short sleep and high blood pressure may increase brain damage

People with high blood pressure who also lack sleep may be at increased risk of reduced cognitive performance and greater brain injury, Monash University research has found.

2 Dec 2024

From potential to practice: A blueprint for responsible AI in healthcare

Researchers developed comprehensive AI guidelines to ensure safe, equitable, and effective integration into healthcare, with a case study highlighting ambient documentation applications.

2 Dec 2024

Hypothalamic deep brain stimulation restores walking after spinal cord injury

Scientists have identified neurons in the lateral hypothalamus that can be targeted through deep brain stimulation to improve walking after spinal cord injury (SCI). This innovative approach shows promise in both animal models and initial human trials, paving the way for groundbreaking treatments.

2 Dec 2024

Concizumab shows promising results for hemophilia patients

For people with the bleeding disorder hemophilia, life can seem like one continuous state of alertness. If they accidentally cut their finger while chopping vegetables, they have to immediately administer the clotting factor protein that their body either lacks or does not produce enough of.

2 Dec 2024

IL-15 improves the effectiveness of GPC3 CAR T cells in targeting solid tumors

The study reveals IL-15's role in enhancing GPC3 CAR T cell therapy, improving tumor targeting and T cell survival in patients with solid cancers.

2 Dec 2024

Natural polyphenol boosts mitochondrial function and muscle performance during aging

Oleuropein enhances mitochondrial calcium uptake, reversing age-related declines in muscle function and energy metabolism, with promising clinical potential.

2 Dec 2024

New study explores obecabtagene autoleucel for adults with hard-to-treat leukemia

FELIX study results reveal obe-cel's potential in relapsed B-cell ALL, achieving 77% remission with low severe toxicity, enhancing CAR T-cell therapy outcomes.

2 Dec 2024

Capsule sponge test revolutionizes GERD diagnosis, reduces unnecessary endoscopies

Capsule sponge testing, a minimally invasive diagnostic tool, effectively triages gastroesophageal reflux disease (GERD) patients, reducing unnecessary endoscopies by 70% and accurately identifying high-risk cases for Barrett’s esophagus and cancer in real-world clinical settings.

1 Dec 2024

Neural connectivity predicts deep brain stimulation success in essential tremor

Study unveils how specific cortico-thalamic connectivity patterns influence essential tremor suppression with deep brain stimulation (DBS). It highlights the contralateral thalamus as a pivotal driver of tremor modulation and potential pathways for enhanced intervention strategies.

1 Dec 2024