Mutation News and Research

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Researchers map cancer driver mutations across the human genome

In a recent study published in Nature Biotechnology, researchers explored the causes of cancer by mapping somatic mutation rates across the human genome.

22 Jun 2022

Scientists discover 15 additional genetic mutations linked to KCNK9 imprinting syndrome

A collaborative team of scientists led by Mayo Clinic's Center for Individualized Medicine has discovered 15 additional genetic mutations in the KCNK9 gene that cause a neurodevelopmental syndrome.

21 Jun 2022

Computer simulation model helps understand why chemotherapy resistance occurs

Understanding why and how chemotherapy resistance occurs is a major step toward optimizing treatments for cancer.

21 Jun 2022

TB-causing bacteria can evolve rapidly in response to new environments, study says

Researchers have identified how the bacterium that causes tuberculosis (TB) can evolve rapidly in response to new environments, says a study published today in eLife.

21 Jun 2022

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

Researchers evaluated the efficacy of PHELA, a traditional African drug, against SARS-CoV-2 in vitro.

21 Jun 2022

New model rapidly scans the genome of cancer cells and identifies mutations that drive tumor growth

Cancer cells can have thousands of mutations in their DNA. However, only a handful of those actually drive the progression of cancer; the rest are just along for the ride.

20 Jun 2022

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

In a recent study posted to the bioRxiv* preprint server, researchers at Weill Cornell Medical College assessed the cleavability of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants of concern (VOCs) and related coronaviruses by several proteases of the host.

19 Jun 2022

New discovery could lead to the development of therapeutic approaches for retinitis pigmentosa

Retinitis pigmentosa, a degenerative genetic disease of the eye, is characterized by progressive vision loss, usually leading to blindness.

17 Jun 2022

Study explains the structural basis of higher ACE2 binding affinity of Omicron sub-variants

A team of scientists from China has recently deciphered the structural basis of comparatively higher binding affinity of two Omicron sub-variants, namely B.1.1 and B.2, for human angiotensin-converting enzyme 2 (ACE2).

17 Jun 2022

SARS-CoV-2 variant-specific polymerase chain reaction assay for SARS-CoV-2 genomic surveillance

Researchers reported on the misclassification of the SARS-CoV-2 Omicron BA.1 subvariant as Omicron BA.2 subvariant in an automated variant-specific polymerase chain reaction analysis.

17 Jun 2022

Novel luminescent biosensor detects SARS-CoV-2 spike protein using cell phone camera

In a recent study posted to the bioRxiv* pre-print server, researchers developed a novel Binding Activated Tandem split enzyme (BAT) biosensor for the detection of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein.

16 Jun 2022

NSP1 found to act as an immune evasion factor in SARS-CoV-2 infections

A new study explores the role of non-structural protein 1 (NSP1) in SARS-CoV-2 infection and pathogenesis.

16 Jun 2022

Four interdisciplinary teams will receive $100 million to solve the toughest challenges in cancer research

The Cancer Grand Challenges program will award $100 million to four interdisciplinary teams from around the world to solve some of the toughest challenges in cancer research.

16 Jun 2022

Research suggests profound SARS-CoV-2 mutations are rare even among immunosuppressed

A recent article posted to the medRxiv* preprint server assessed whether host traits like immunosuppression aids severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mutational drift.

16 Jun 2022

Androgen receptor signaling affects response to targeted therapy in people with melanoma

Androgen receptor (AR) signaling affects response to BRAF/MEK inhibitor therapy in both males and females with melanoma, researchers from The University of Texas MD Anderson Cancer Center showed in a study published today in Nature.

15 Jun 2022

Chromosome organization affects evolution of DNA in archaea

The structure of how DNA is stored in archaea makes a significant difference to how quickly it evolves, according to a new study by Indiana University researchers.

14 Jun 2022

The potential mechanisms of SARS-CoV-2 to induce DNA damage

Researchers described potential mechanisms of coronaviruses that could lead to DNA damage and the potential link between SARS-CoV-2 activity and such mechanisms.

14 Jun 2022

Lineages of monkeypox virus in the United States

In a recent work posted to the bioRxiv* preprint server, researchers analyzed various monkeypox virus (MPXV) lineages identified recently in the United States (US).

14 Jun 2022

SARS-CoV-2 recombinant isolated from chronic COVID-19 patient

A new research paper in the journal Viruses reports the isolation of a recombinant strain in a patient infected with the virus for over a year.

13 Jun 2022

RNA exosomes play a key role in B cell development, UTSW study suggests

New research from UT Southwestern suggests that RNA exosomes – the cellular machines that degrade old molecules of RNA – play a key role in the development of B cells, which are critical to the immune system's ability to protect against infection.

13 Jun 2022

Mutation News and Research

Researchers map cancer driver mutations across the human genome

Scientists discover 15 additional genetic mutations linked to KCNK9 imprinting syndrome

Computer simulation model helps understand why chemotherapy resistance occurs

TB-causing bacteria can evolve rapidly in response to new environments, study says

Study finds traditional African drug inhibits growth of SARS-CoV-2 infection

New model rapidly scans the genome of cancer cells and identifies mutations that drive tumor growth

SARS-CoV-2 variants of concern exhibit divergent interactions with host proteases

New discovery could lead to the development of therapeutic approaches for retinitis pigmentosa

Study explains the structural basis of higher ACE2 binding affinity of Omicron sub-variants

SARS-CoV-2 variant-specific polymerase chain reaction assay for SARS-CoV-2 genomic surveillance

Novel luminescent biosensor detects SARS-CoV-2 spike protein using cell phone camera

NSP1 found to act as an immune evasion factor in SARS-CoV-2 infections

Four interdisciplinary teams will receive $100 million to solve the toughest challenges in cancer research

Research suggests profound SARS-CoV-2 mutations are rare even among immunosuppressed

Androgen receptor signaling affects response to targeted therapy in people with melanoma

Chromosome organization affects evolution of DNA in archaea

The potential mechanisms of SARS-CoV-2 to induce DNA damage

Lineages of monkeypox virus in the United States

SARS-CoV-2 recombinant isolated from chronic COVID-19 patient

RNA exosomes play a key role in B cell development, UTSW study suggests

Managing vibration in IVF laboratories

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

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