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Scientists identify enzyme to prevent beta-amyloids formation in Alzheimer patients

The brains of Alzheimer patients have high accumulations of the material beta-amyloid, which appear in the form of plaques. The precursors of these plaques are believed to be the underlying cause of the nerve cell loss that leads to the disruptions in memory that characterize Alzheimer's disease. The main aim of many Alzheimer therapies is therefore to inhibit the formation of beta-amyloid. Since beta-amyloid is cleaved from the so-called amyloid precursor protein (APP), scientists have focused on stopping the two enzymes that attack the precursor protein. These act like molecular scissors and cut out the beta-amyloid fragment. Blocking these scissors precludes the formation of beta-amyloid.

31 Jul 2010

Clinical Pharmacokinetics Research Laboratory deploys AB SCIEX mass spectrometry technology

AB SCIEX, a global leader in life science analytical technologies, today announced that the Clinical Pharmacokinetics Research Laboratory at the University of Rhode Island's College of Pharmacy is using AB SCIEX mass spectrometry technology to develop a novel test that would enable clinical researchers to use saliva to monitor immunosuppressant drugs commonly administered to make organ transplants successful.

28 Jul 2010

Waters second-quarter 2010 sales increase 8% to $391 million

Waters Corporation reported today second quarter 2010 sales of $391 million, an increase of 8% over sales of $363 million in the second quarter of 2009. These quarterly sales include an adverse foreign currency translation impact of approximately 1%. On a GAAP basis, earnings per diluted share for the second quarter were $0.90, compared to $0.72 for the second quarter in 2009.

28 Jul 2010

AB SCIEX collaborates with CDC to improve laboratory hormone testing technique

AB SCIEX, a global leader in life science analytical technologies, today announced a collaboration with the Centers for Disease Control and Prevention (CDC) and the CDC Foundation to facilitate the use of mass spectrometry technologies in clinical laboratories for hormone testing. This collaboration is intended to help support the CDC's Hormone Standardization Project for improving the reliability of laboratory results used to help assess disease risk and monitor treatment.

28 Jul 2010

Millennium Laboratories urges for increase in physician reimbursement for POC urine drug screening

Millennium Laboratories, Inc., a national, research-based medication monitoring company specifically focused on clinicians who treat chronic pain, strongly advocated for an increase in physician reimbursement for point-of-care urine drug screening at the Annual Clinical Laboratory Public Meeting of the Centers for Medicare and Medicaid Services on July 22, 2010.

27 Jul 2010

Thermo Fisher Scientific highlights products, services for clinical research and specialty diagnostics at AACC 2010

Thermo Fisher Scientific Inc., the world leader in serving science, will highlight its innovative offering of products and services for clinical research and specialty diagnostics during the American Association for Clinical Chemistry (AACC) Annual Meeting and Clinical Lab Expo held in Anaheim, California, July 25 - 29, 2010.

From Thermo Fisher Scientific Inc. 27 Jul 2010

Waters to present MassTrak solutions at American Association of Clinical Chemistry annual meeting

Waters Corporation is showcasing its portfolio of MassTrak solutions at the American Association of Clinical Chemistry annual meeting and Clinical Lab Expo July 25 - 29, 2010 in Anaheim in exhibit booth #4447. Waters portfolio of MassTrak Solutions for the clinical laboratory combines the power of separations science, tandem mass spectrometry, specialized chemistries, software, and support services in ways designed to optimize laboratory processes.

27 Jul 2010

AB SCIEX and ETH partner to accelerate analysis and improve results for metabolomics

AB SCIEX, a global leader in life science analytical technologies, today announced that it is working with scientists at the ETH Zurich Institute of Molecular Systems Biology as part of the Swiss Systems Biology Program (SystemsX.ch) to accelerate analysis and improve results for metabolomics, which is the scientific study of chemical processes involving metabolites.

21 Jul 2010

ACS to hold symposium on Deepwater Horizon oil spill

The American Chemical Society (ACS) will hold a special day-long symposium on the Deepwater Horizon oil spill on Tuesday, Aug. 24 during its National Meeting & Exposition here. The symposium, which includes almost a dozen experts, will examine topics ranging from the spill's effects on marine life to its effects on the safety of seafood. It will take place from 8 a.m. to 4 p.m. in Room 210C of the Boston Convention and Exhibition Center, followed by an open-discussion session from 4:30 p.m. to 6 p.m.

21 Jul 2010

New tactics for repelling, controlling disease-carrying insects

In the battle between insect predators and their prey, chemical signals called kairomones serve as an early-warning system. Pervasively emitted by the predators, the compounds are detected by their prey, and can even trigger adaptations, such a change in body size or armor, that help protect the prey. But as widespread as kairomones are in the insect world, their chemical identity has remained largely unknown. New research by Rockefeller University's Joel E. Cohen and colleagues at the University of Haifa in Israel has identified two compounds emitted by mosquito predators that make the mosquitoes less inclined to lay eggs in pools of water.

17 Jul 2010

Study compares denture stomatitis genes with whole transcriptome for salivary biomarker analysis

The goal of the study was to compare whole-transcriptome, mucosal gene expression in Candida albicans (a parasitic fungus that can infect the mouth) associated chronic denture stomatitis to that of healthy oral mucosa and perform proteomic analyses of potential salivary biomarkers. Denture stomatitis is a condition in which the mucosa underneath a denture becomes inflamed and sometimes painful.

16 Jul 2010

Research provides better understanding of drugs used to treat, prevent cardiovascular disease

Using chemical labeling and mass spectrometry-based techniques, Mark Chance, PhD, director of the Case Western Reserve University School of Medicine Center for Proteomics and Bioinformatics and professor of physiology and biophysics; Sayan Gupta, PhD, instructor at the Case Center for Proteomics and Bioinformatics; and a research team from the University of Oxford, for the first time, were able to take a high resolution picture of the open state of a K+ channel, allowing them to comparatively analyze gating mechanisms important to heart function and nerve signaling - in addition these techniques have already permitted Case Western investigators to gain a deeper understanding of G-protein coupled receptors.

14 Jul 2010

IRIC scientists identify vitamin B3 as potential antifungal treatment

A team of scientists from the Institute for Research in Immunology and Cancer (IRIC) of the University of Montreal have identified vitamin B3 as a potential antifungal treatment. Led by IRIC Principal Investigators Martine Raymond, Alain Verreault and Pierre Thibault, in collaboration with Alaka Mullick, from the Biotechnology Research Institute of the National Research Council Canada, the study is the subject of a recent article in Nature Medicine.

9 Jul 2010

Novel molecular pathway that regulates invasive growth, metastasis in ER-positive breast cancer discovered

A multi-disciplinary team of international researchers from Ghent University in Belgium, National Human Genome Research Institute (NHGRI) in the US, Imperial College London in the United Kingdom, and INSERM in France have uncovered a novel molecular pathway that regulates invasive growth and metastasis in estrogen receptor-positive breast cancer.

6 Jul 2010

USPTO grants Vermillion Alzheimer's disease biomarker patent

Vermillion, Inc., a molecular diagnostics company, today announced that the United States Patent and Trademark Office (USPTO) has issued a notice of allowance of a patent entitled "Biomarkers for Alzheimer's disease" to the Company.

29 Jun 2010

Hydrophobic proteins may serve as biomarkers for treating colorectal cancer

Colorectal cancer, cancer of the colon and rectum, is a common cause of mortality worldwide. Statistical data showed that the number of deaths caused by colorectal cancer is increasing in both men and women.

25 Jun 2010

Biodesix awarded US patent for VeriStrat serum test

Biodesix, Inc., a company developing and commercializing molecular diagnostics for personalized medicine, announced today that the United States Patent and Trademark Office has awarded to the Company patent number 7,736,905. The patent provides coverage for the Company's first product, VeriStrat®, which is used by physicians to help guide therapy for patients with advanced lung cancer. The allowed claims are directed towards the serum-based identification of patients likely to benefit from epidermal growth factor targeted therapy.

22 Jun 2010

Biotage launches ISOLUTE SLE+ sample preparation columns

Biotage, a leading supplier of tools and technology for medicinal and analytical chemistry, announced the introduction of ISOLUTE SLE+ High-Performance Supported Liquid Extraction sample preparation columns. The announcement occurred during the 58th ASMS Conference on Mass Spectrometry and Allied Topics in Salt Lake City, Utah USA.

22 Jun 2010

Bone samples act as the ultimate biomarker for environmental pollution: Researchers

Exposure to chemical pollutants is of growing concern to regulators, health workers, and environmentalist groups alike. Now, researchers in the US and Russia have demonstrated that samples of human bone can act as a biological marker for dozens of metals and toxic elements across the periodic table. They describe details in a study published in the International Journal of Environment and Health.

18 Jun 2010

NSF awards Florida State University $17.5M grant to build 21-tesla magnet system for large molecule analyses

The National High Magnetic Field Laboratory at Florida State University is planning to build a state-of-the-art magnet system that will transform the study of complex environmental and biological samples. A better understanding of fossil and biological fuels, for example, could lead to applications for reducing carbon emissions and the development of new, sustainable fuels.

16 Jun 2010

Spectrometry News and Research

Scientists identify enzyme to prevent beta-amyloids formation in Alzheimer patients

Clinical Pharmacokinetics Research Laboratory deploys AB SCIEX mass spectrometry technology

Waters second-quarter 2010 sales increase 8% to $391 million

AB SCIEX collaborates with CDC to improve laboratory hormone testing technique

Millennium Laboratories urges for increase in physician reimbursement for POC urine drug screening

Thermo Fisher Scientific highlights products, services for clinical research and specialty diagnostics at AACC 2010

Waters to present MassTrak solutions at American Association of Clinical Chemistry annual meeting

AB SCIEX and ETH partner to accelerate analysis and improve results for metabolomics

ACS to hold symposium on Deepwater Horizon oil spill

New tactics for repelling, controlling disease-carrying insects

Study compares denture stomatitis genes with whole transcriptome for salivary biomarker analysis

Research provides better understanding of drugs used to treat, prevent cardiovascular disease

IRIC scientists identify vitamin B3 as potential antifungal treatment

Novel molecular pathway that regulates invasive growth, metastasis in ER-positive breast cancer discovered

USPTO grants Vermillion Alzheimer's disease biomarker patent

Hydrophobic proteins may serve as biomarkers for treating colorectal cancer

Biodesix awarded US patent for VeriStrat serum test

Biotage launches ISOLUTE SLE+ sample preparation columns

Bone samples act as the ultimate biomarker for environmental pollution: Researchers

NSF awards Florida State University $17.5M grant to build 21-tesla magnet system for large molecule analyses

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

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