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New project aims to improve the efficacy and safety of CAR T therapies for solid tumors

Partners in the international consortium CAR T-REX announce the awarding of a highly competitive EIC Pathfinder Open grant, following the positive evaluation of their project entitled 'CAR T Cells Rewired to Prevent EXhaustion in the Tumour Microenvironment'.

23 Jun 2023

Cell and gene therapy CDMO Andelyn Biosciences celebrates over 20 years of leadership and innovation with opening of new 180,000 square foot manufacturing headquarters

Andelyn Biosciences, a pioneer in the development and manufacturing of cell and gene therapies, today formally inaugurates its new manufacturing headquarters, the Andelyn Corporate Center (ACC), located in the Innovation District in Columbus, Ohio.

From Andelyn Biosciences 23 Jun 2023

World's largest gathering of NF community convenes in Arizona to advance research and care

From June 21 through June 27, the largest gathering of NF researchers, clinicians, and patients in the world will take place at the Fairmont Scottsdale Princess in Scottsdale, Arizona.

22 Jun 2023

Building resilient brains: strategies for promoting brain health in older adults

Researchers reviewed the overarching theme of brain health from the perspective of aging and preventive care.

21 Jun 2023

$3.3M HHS grant supports UTHealth Houston study on combination treatment strategy for pancreatic cancer

A combination strategy of endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) with chemotherapy for pancreatic cancer will be studied at UTHealth Houston through a $3.3 million grant from the National Cancer Institute by the U.S. Department of Health and Human Services.

20 Jun 2023

3D-printed vaginal ovules offer promising treatment for endometriosis

3D-printed vaginal ovules offer controlled release and targeted treatment, showing promise for conditions like endometriosis.

20 Jun 2023

INTEGRA Biosciences’ pipettes help to advance cancer drug discovery

The Institute for Cancer Research (ICR), part of the University of London, is using VIAFLO electronic pipettes from INTEGRA Biosciences to streamline its preclinical drug screening and translational medicine workflows.

From INTEGRA Biosciences 20 Jun 2023

Intranasal delivery of CRISPR/Cas9 therapeutics may help treat chronic anxiety

A study in mice reports a CRISPR/Cas9 gene-editing delivery system, capable of bypassing the blood-brain-barrier and modulating neuronal receptor pathways, to treat chronic anxiety.

20 Jun 2023

Researchers review the principles of universal vaccine development for key pandemic potential viruses

A recent review addressed the efforts to develop universal vaccines for viruses at family and genus levels.

16 Jun 2023

Determining the effect of estriol treatment on cerebral cortex in the preclinical model of MS

Treating a mouse model of multiple sclerosis with the pregnancy hormone estriol reversed the breakdown of myelin in the brain's cortex, a key region affected in multiple sclerosis, according to a new UCLA Health study.

16 Jun 2023

Gut microbiota holds clues to predicting Alzheimer's risk

Gut microbiome alterations in preclinical Alzheimer's disease (AD) were investigated, revealing distinct taxonomic composition and potential markers of AD risk. These findings contribute to understanding AD pathology and offer insights into gut-derived markers for AD.

15 Jun 2023

$1.9 million grant awarded to explore the effect of antifungal drugs in Crohn's patients

Dr. Iliyan D. Iliev, an associate professor of immunology in medicine in the Division of Gastroenterology and Hepatology, co-director of the Microbiome Core and a member of the Jill Roberts Institute for Research in Inflammatory Bowel Disease (IBD) at Weill Cornell Medicine, is the lead investigator on a grant to Weill Cornell Medicine from The Leona M. and Harry B. Helmsley Charitable Trust to target pathogenic fungi in patients with Crohn's disease.

15 Jun 2023

Study finds altered gut bacteria in people with early signs of Alzheimer's disease

People in the earliest stage of Alzheimer's disease - after brain changes have begun but before cognitive symptoms become apparent - harbor an assortment of bacteria in their intestines that differs from the gut bacteria of healthy people, according to a study by researchers at Washington University School of Medicine in St. Louis.

14 Jun 2023

Phone menu test assesses daily functioning in people at risk of developing Alzheimer's disease

A new study by investigators from Mass General Brigham has found that a brief, simulated task of navigating a phone menu can detect the earliest changes in daily functioning in people at risk of developing Alzheimer's disease.

14 Jun 2023

Four pancreatic injury safety biomarkers identified and evaluated by PSTC

Critical Path Institute (C-Path) today announced that the Biomarker Qualification Program (BQP) at the Center for Drug Evaluation and Research (CDER) in the U.S. Food and Drug Administration (FDA) issued a Biomarker Letter of Support (LOS) for four pancreatic injury safety biomarkers identified and evaluated by C-Path's Predictive Safety Testing Consortium's (PSTC) Pancreatic Injury Working Group (PIWG).

14 Jun 2023

From delicacy to danger: The rising tide of shellfish allergies in children revealed

Shellfish consumption is on the rise, but so are shellfish allergies, particularly among children. A recent review delves into the epidemiology, symptoms, diagnosis, and management of shellfish allergies, highlighting the need for improved diagnostic tools and potential allergen immunotherapy.

13 Jun 2023

Berlin scientists further improve nasal vaccine against coronavirus

After having successfully tested a mucosal vaccine against coronavirus in animals just months ago, Berlin scientists have now further developed their live SARS-CoV-2 vaccine.

13 Jun 2023

Charles River Laboratories Launches Off-the-Shelf Lentiviral Vector Packaging Plasmids

Charles River Laboratories International, Inc. (NYSE: CRL) today announced the launch of its off-the-shelf lentiviral vector (LVV) packaging plasmids, providing a streamlined solution to the challenges associated with plasmid sourcing in cell and gene therapies.

From Charles Rivers Laboratories Cell and Gene Therapy 13 Jun 2023

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

A new research paper was published in Oncotarget's Volume 14 on June 12, 2023, entitled, "LP-284, a small molecule acylfulvene, exerts potent antitumor activity in preclinical non-Hodgkin's lymphoma models and in cells deficient in DNA damage repair."

13 Jun 2023

New cell culture model generates the alveolar macrophage in the lab

Researchers at Texas Biomedical Research Institute have succeeded in generating the lung's most important immune cell, the alveolar macrophage, in the lab.

12 Jun 2023

Preclinical News and Research

New project aims to improve the efficacy and safety of CAR T therapies for solid tumors

Cell and gene therapy CDMO Andelyn Biosciences celebrates over 20 years of leadership and innovation with opening of new 180,000 square foot manufacturing headquarters

World's largest gathering of NF community convenes in Arizona to advance research and care

Building resilient brains: strategies for promoting brain health in older adults

$3.3M HHS grant supports UTHealth Houston study on combination treatment strategy for pancreatic cancer

3D-printed vaginal ovules offer promising treatment for endometriosis

INTEGRA Biosciences’ pipettes help to advance cancer drug discovery

Intranasal delivery of CRISPR/Cas9 therapeutics may help treat chronic anxiety

Researchers review the principles of universal vaccine development for key pandemic potential viruses

Determining the effect of estriol treatment on cerebral cortex in the preclinical model of MS

Gut microbiota holds clues to predicting Alzheimer's risk

$1.9 million grant awarded to explore the effect of antifungal drugs in Crohn's patients

Study finds altered gut bacteria in people with early signs of Alzheimer's disease

Phone menu test assesses daily functioning in people at risk of developing Alzheimer's disease

Four pancreatic injury safety biomarkers identified and evaluated by PSTC

From delicacy to danger: The rising tide of shellfish allergies in children revealed

Berlin scientists further improve nasal vaccine against coronavirus

Charles River Laboratories Launches Off-the-Shelf Lentiviral Vector Packaging Plasmids

Analyzing the role of LP-284 Hodgkin's lymphoma models and in DNA damage repair

New cell culture model generates the alveolar macrophage in the lab

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