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Research says in SARS-CoV-2 canine infection, transmission unlikely

A new study published on the preprint server bioRxiv* in September 2020 shows that pet dogs have been falling sick and dying of a mysterious respiratory infection, often showing the presence of anti- severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies, even though in many cases they do not test positive for COVID-19.

24 Sep 2020

Molecular insights may foster effective therapies for COVID-19 patients

Viral and bacterial pathogens wield pathogenic or virulent proteins that interact with high-value targets inside human cells, attacking what is known as the host interactome. The host interactome is the network map of all the protein-protein interactions inside cells.

24 Sep 2020

Polyphenolic compound offers new therapeutic option for chronic inflammatory disorders

Various plants and their products are known to contain "bioactive" ingredients that can alleviate human diseases. These "phytocompounds" often contain restorative biological properties such as anti-cancerous, antioxidant, and anti-inflammatory effects.

24 Sep 2020

Study reveals how loss of protein arginine methyltransferase affects proper brain development

Normal brain development requires a precise interplay between neuronal and non-neuronal (also called glial) cells.

24 Sep 2020

Study: R-spondin growth factor reduces intestinal tumors in early phase of colorectal cancer

Colorectal cancer constitute the third most common cancer in the Western world. Their incidence constantly increases as the population ages, and despite recent advances in colorectal cancer therapy, the cancer metastasizes in every third of colorectal cancer patients, and a significant part of these patients eventually die from the disease

24 Sep 2020

Researchers identify a compound that inhibits growth of schwannomas

Schwannomas are tumors of the peripheral nervous system, which often occur in the genetic disease neurofibromatosis type 2. The research group of Prof. Dr. Helen Morrison at the Leibniz Institute on Aging - Fritz Lipmann Institute in Jena, Germany, identified a compound that inhibits the growth of such tumors and improves nerve function.

21 Sep 2020

KRASG12C inhibitor sotorasib shows durable clinical benefits for solid cancers

In a Phase I clinical trial for patients with advanced solid cancers marked by KRAS G12C mutations, the KRASG12C inhibitor sotorasib (AMG 510) resulted in manageable toxicities and durable clinical benefits.

21 Sep 2020

Adding abemaciclib to hormonal therapy reduces recurrence in patients with HR+ HER2- early breast cancer

Adding abemaciclib to hormonal therapy reduces the risk of cancer recurrence by 25% in patients with high-risk early hormone receptor positive (HR+) human epidermal growth factor receptor 2 negative (HER2-) breast cancer, according to results from a study at ESMO 2020.

21 Sep 2020

Combined use of three drugs linked with lower lung cancer incidence and mortality

Combined use of aspirin, statins, and metformin is associated with decreased lung cancer incidence and mortality, according to a study published in the Journal of Thoracic Oncology.

17 Sep 2020

Higher viral loads can increase mortality rate in patients hospitalized with COVID-19 and cancer

Higher viral loads are associated with a greater risk of death among cancer and non-cancer patients hospitalized with coronavirus disease 2019 (COVID-19), researchers report September 15 in the journal Cancer Cell.

17 Sep 2020

Candidate monoclonal antibody shows hope as COVID-19 treatment

Researchers in the United States have described the effectiveness of a candidate monoclonal antibody currently being evaluated in a Phase 1 trial as a therapy for coronavirus disease 2019 (COVID-19) and its causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

16 Sep 2020

SARS-CoV-2 N protein forms biomolecular condensates with viral RNA

Now, a study by researchers from the University of California has shown that the N protein forms biomolecular condensates with the viral RNA in both in vitro and in vivo studies. The research titled, ‘SARS CoV-2 nucleocapsid protein forms condensates with viral genomic RNA’, was published on the preprint server bioRxiv on September 14th, 2020.

15 Sep 2020

Scientists unravel the molecular mechanism underlying the causes of colorectal cancer

A team of scientists has unraveled the molecular mechanism behind one of the causes of colorectal cancer, and a treatment target.

15 Sep 2020

Buckling could trigger embryo morphogenesis

The embryo of an animal first looks like a hollow sphere. Invaginations then appear at different stages of development, which will give rise to the body's structures (the brain, digestive tract, etc.).

14 Sep 2020

Cell signaling research rings warning bells over an emerging cancer drug target

Researchers at the Babraham Institute have used their understanding of cellular signalling to highlight a pitfall in an emerging treatment for cancer and inflammation.

14 Sep 2020

Study highlights the importance of considering strain differences when designing therapies

Interferon (IFN) responses are one of the first defenses the body mounts against viral infections, and research has shown that it plays a role controlling viral replication.

11 Sep 2020

A novel gene involved in primary lymphedema identified

The Human Molecular Genetics laboratory of the de Duve Institute (UCLouvain), headed by Professor Miikka Vikkula, recently identified mutations in a novel gene, ANGPT2, responsible for primary lymphedema.

10 Sep 2020

Brazilian red propolis contains substances with anti-cancer properties

Brazilian red propolis found in beehives along the coast and mangroves in the Northeast region contains two substances with anti-cancer properties. In laboratory tests, they considerably reduced the proliferation of ovarian, breast, and brain cancer cells

10 Sep 2020

Brain inflammation seen in fatal COVID-19 cases

Now, a new study by researchers at the Barts Health NHS Trust and the University of Cambridge in the United Kingdom shows that some patients develop neurological complications tied to COVID-19.

9 Sep 2020

Study sheds new light on function and regulation of APOBEC3B in adrenocortical carcinoma

The cover for issue 36 of Oncotarget features, "Knockdown of APOBEC3B is associated with a lower tumor growth in an adrenocortical carcinoma xenograft mouse model," by Gara, et al. which reported that the role of APOBEC3B in adrenocortical carcinoma and the mechanisms through which its expression is regulated in cancer are not fully understood.

9 Sep 2020

Proliferation News and Research

Research says in SARS-CoV-2 canine infection, transmission unlikely

Molecular insights may foster effective therapies for COVID-19 patients

Polyphenolic compound offers new therapeutic option for chronic inflammatory disorders

Study reveals how loss of protein arginine methyltransferase affects proper brain development

Study: R-spondin growth factor reduces intestinal tumors in early phase of colorectal cancer

Researchers identify a compound that inhibits growth of schwannomas

KRASG12C inhibitor sotorasib shows durable clinical benefits for solid cancers

Adding abemaciclib to hormonal therapy reduces recurrence in patients with HR+ HER2- early breast cancer

Combined use of three drugs linked with lower lung cancer incidence and mortality

Higher viral loads can increase mortality rate in patients hospitalized with COVID-19 and cancer

Candidate monoclonal antibody shows hope as COVID-19 treatment

SARS-CoV-2 N protein forms biomolecular condensates with viral RNA

Scientists unravel the molecular mechanism underlying the causes of colorectal cancer

Buckling could trigger embryo morphogenesis

Cell signaling research rings warning bells over an emerging cancer drug target

Study highlights the importance of considering strain differences when designing therapies

A novel gene involved in primary lymphedema identified

Brazilian red propolis contains substances with anti-cancer properties

Brain inflammation seen in fatal COVID-19 cases

Study sheds new light on function and regulation of APOBEC3B in adrenocortical carcinoma

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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