Respiratory News and Research

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HPV co-testing prospect for HIV-infected women

The risk for cervical precancer and cancer is similar in HIV-infected and HIV-uninfected women with normal cervical cytology and no evidence of oncogenic human papillomavirus infection, research shows.

30 Jul 2012

Enoxaparin prevents PVT in advanced cirrhosis

Enoxaparin significantly reduces portal vein thrombosis and increases overall survival in patients with advanced cirrhosis, the results of an Italian study show.

30 Jul 2012

Hydroxychloroquine fails to modify HIV in patients not taking ART

The use of hydroxychloroquine does not reduce CD8 cell activation in HIV-infected patients not taking antiretroviral therapy, research shows.

30 Jul 2012

Strategies to reduce readmission are lacking in US hospitals

A review of US hospitals indicates a lack of implementation of important practices to reduce readmission rates among patients with heart failure and acute myocardial infarction, report researchers.

30 Jul 2012

Erosive hand osteoarthritis ‘a distinct phenotype’

There may be an underlying systemic cause for erosive hand osteoarthritis, suggest study findings showing more inflammatory signs in erosive joints relative to non-erosive joints.

30 Jul 2012

Progress with GSK in advancing VaxiRNA technology earns Alnylam $3.2M milestone payment

Alnylam Pharmaceuticals, Inc., a leading RNAi therapeutics company, announced today that it has earned a development milestone payment from GlaxoSmithKline, totaling $3.2 million. The milestone payment is related to progress in the companies' collaboration on the use of VaxiRNA technology for the production of GSK influenza vaccine.

30 Jul 2012

Sunovion launches ZETONNA Nasal Aerosol for allergic rhinitis

Sunovion Pharmaceuticals Inc. today announced the nationwide availability of ZETONNA (ciclesonide) Nasal Aerosol, 74 mcg once-daily, for the treatment of allergic rhinitis (AR), also known as hay fever or nasal allergies. ZETONNA is a corticosteroid indicated for the treatment of symptoms associated with seasonal allergic rhinitis (SAR) and perennial allergic rhinitis (PAR) in adults and adolescents 12 years of age and older.

30 Jul 2012

Assay Depot launches virtual research laboratory

Assay Depot Inc. today announced the launch of a virtual research laboratory. Developed in partnership with AstraZeneca, the virtual laboratory is a powerful vendor relationship management (VRM) system that gives researchers easy access to a distributed network of thousands of research service providers located inside and outside the company.

30 Jul 2012

Physical activity teaching in UK medical schools virtually “non-existent”

UK medical school teaching on physical activity is “sparse or non-existent,” finds research published online in the British Journal of Sports Medicine.

30 Jul 2012

Genentech's BREVACTA study of ACTEMRA on rheumatoid arthritis meets primary endpoint

Genentech, a member of the Roche Group, today announced that the BREVACTA study of ACTEMRA (tocilizumab) given as a subcutaneous (SC) injection to patients with rheumatoid arthritis (RA) met its primary endpoint.

28 Jul 2012

Takeda resubmits alogliptin and fixed-dose combination therapy NDAs with FDA

Furiex Pharmaceuticals, Inc. today confirmed that Takeda Pharmaceutical Company Limited announced that its wholly-owned subsidiary, Takeda Global Research & Development Center, Inc. has resubmitted New Drug Applications (NDAs) to the U.S. Food and Drug Administration (FDA) for alogliptin and fixed-dose combination therapy alogliptin and pioglitazone for the treatment of type 2 diabetes in adults.

28 Jul 2012

EC approves Vertex's KALYDECO for treatment of cystic fibrosis

Vertex Pharmaceuticals Incorporated announced today that the European Commission has approved KALYDECOTM (ivacaftor) for people with cystic fibrosis (CF) ages 6 and older who have at least one copy of the G551D mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.

28 Jul 2012

Vitamin D link to lung function in smokers

Vitamin D levels seem to determine the rate of lung function decline among smokers, the results of an American study show.

27 Jul 2012

Increased risk for AMI following hip- and knee-replacement surgery

Elderly patients are at a significantly increased risk for acute myocardial infarction in the 2 weeks following total hip- or knee-replacement surgery, research shows.

27 Jul 2012

Long-term use of reverse geometry lenses may induce inflammatory response

Continuous long-term overnight use of reverse geometry lenses results in a significantly increased presence of inflammatory mediators compared with wearing 30-night silicone-hydrogel contact lenses or wearing no lenses, show study results.

27 Jul 2012

Discrepancies in ICU use identified

An analysis of intensive care unit use in the USA reveals that many patients admitted to this specialist department are at low risk for mortality, while more than half of patients with a high mortality risk are admitted to other departments.

27 Jul 2012

Anticancer benefit to giving birth after 30

Women who last give birth after the age of 30 years have a decreased risk for endometrial cancer, researchers report in the American Journal of Epidemiology.

27 Jul 2012

‘Narrow therapeutic window’ for oxygen in brain injury

Hyperoxia, as well as hypoxia, early after hospital admission is associated with poor outcomes and mortality in patients with traumatic brain injury, report researchers in the Archives of Surgery.

27 Jul 2012

Orthognathic surgery requires a balancing act in anesthetic technique

Orthognathic surgery, affecting the jaws and face, requires a balancing act in anesthetic technique. Limiting blood loss, avoiding respiratory depression, and averting postoperative nausea and vomiting lead to optimum patient outcomes. The use of the drugs propofol and remifentanil are increasing because they can meet these needs; however, patients may subsequently experience more postoperative pain.

27 Jul 2012