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TUM scientists show how diabetes damages small blood vessels around the heart

Diabetics have a significantly higher risk of suffering a heart attack. A research team at the Technical University of Munich has now identified one of the causes: Diabetes is associated with the loss of small blood vessels around the heart.

23 Mar 2017

MSU lands $727,000 NIH grant to improve use of fish as disease models for human medicine

Michigan State University has landed a $727,000 grant from the National Institutes of Health to improve the use of fish as disease models for human medicine.

23 Mar 2017

Study compares arm measures to BMI for assessing nutritional status of leukemia survivors

Arm anthropometry is a simple method to determine if a person is overweight or obese, and because it can distinguish between fat and muscle mass, unlike body mass index (BMI), it is a valuable method for assessing muscle loss in long-term survivors of childhood cancer.

23 Mar 2017

Researchers uncover major clue to how mucus becomes abnormal in CF airways

People with cystic fibrosis (CF) suffer repeated lung infections because their airway mucus is too thick and sticky to keep bacteria, viruses, and other pathogens from causing chronic infection.

23 Mar 2017

Genome sequencing approach opens door to therapy options for rare, neglected cancers

An international team of scientists led by the Icahn School of Medicine at Mount Sinai and UConn School of Medicine have reported the results of a genome sequencing study for an extremely rare form of cancer.

23 Mar 2017

Researchers unravel how drug interacts with ribosome to halt protein production

The discovery of a chemical compound that halts the production of a small set of proteins while leaving general protein production untouched suggests a new drug search strategy: Find compounds that target undesired proteins before they are even made.

23 Mar 2017

Study finds steady increase in BRCA testing among low-risk women

Discovery of the BRCA genetic mutation in the mid-90s represented a breakthrough in breast and ovarian cancer prevention. About 5-10% of breast cancer cases and 10-18% of ovarian cancer cases can be attributed to two BRCA mutations.

23 Mar 2017

Researchers develop novel genetic score to calculate age-specific risk of Alzheimer's disease

An international team of scientists, led by researchers at University of California San Diego School of Medicine and University of California San Francisco, has developed a novel genetic score that allows individuals to calculate their age-specific risk of developing Alzheimer's disease (AD), based upon genetic information.

22 Mar 2017

New genetic biomarker for colon cancer may lead to development of personalized treatment

Researchers at Baylor Scott & White Research Institute identified a new genetic biomarker for colon cancer that may lead to development of more targeted treatment of the disease.

22 Mar 2017

UC researchers advocate ‘precision medicine’ approach to studying and treating Parkinson's disease

Two landmark publications with one or more co-authors from the University of Cincinnati Gardner Neuroscience Institute outline a transformative approach to defining, studying and treating Parkinson's disease.

22 Mar 2017

Heroin use linked to epigenetic alterations in the brain

Heroin use is associated with excessive histone acetylation, an epigenetic process that regulates gene expression, and more years of drug use correlate with higher levels of hyperacetylation, according to research conducted at The Icahn School of Medicine at Mount Sinai and published in the journal Biological Psychiatry.

22 Mar 2017

Study shows safety of Schwann cell transplantation for treating subacute thoracic spinal cord injury

A Phase I clinical trial that targeted individuals with new onset paraplegia to evaluate the safety of transplanting their own potentially neuroprotective Schwann cells into a trauma-induced spinal cord lesion showed no evidence of adverse effects after 1 year.

22 Mar 2017

New technology may provide non-invasive approach to diagnose and monitor prostate cancer

Technology being developed at Washington State University provides a non-invasive approach for diagnosing prostate cancer and tracking the disease's progression.

22 Mar 2017

USC study close to finding gene involved in cleft lip and palate

A group of researchers has found that three siblings born with cleft lip and palate share a common gene mutation associated with the birth defect.

22 Mar 2017

Study identifies potential Achilles heel of kinase-driven cancers

Scientists identify two signaling proteins in cancer cells that make them resistant to chemotherapy, and show that blocking the proteins along with chemotherapy eliminate human leukemia in mouse models.

22 Mar 2017

New study correlates 80 cancer-related gene mutations with 34 AML subgroups

A large, new study of adults with acute myeloid leukemia (AML) correlates 80 cancer-related gene mutations with five subtypes of AML, which are defined by the presence of specific chromosomal abnormalities. The findings might help guide mutation testing and treatment decisions in the future.

21 Mar 2017

Efficacy of innovative gene therapy can be tested quickly and cost-effectively using new cellular model

Using a new cellular model, innovative gene therapy approaches for the hereditary immunodeficiency Chronic Granulomatous Disease can be tested faster and cost-effectively in the lab for their efficacy.

21 Mar 2017

Genotype-guided warfarin dosing linked to reduced risk of adverse events

Using genetic testing to help personalize doses of warfarin therapy given to patients undergoing elective orthopedic surgery appears to lower the risk of combined adverse events compared with clinically guided dosing, according to research presented at the American College of Cardiology's 66th Annual Scientific Session.

21 Mar 2017

Research findings hold promise to generate blood cell precursors from hPSCs

The Galat laboratory at Stanley Manne Children's Research Institute, Ann & Robert H. Lurie Children's Hospital of Chicago, has developed an elegant system to derive blood cell precursors from human pluripotent stem cells (hPSC).

21 Mar 2017

Sandia researchers develop smartphone-based device to rapidly detect mosquito-borne viruses

Add rapid, mobile testing for Zika and other viruses to the list of things that smartphone technology is making possible. Researchers at Sandia National Laboratories have developed a smartphone-controlled, battery-operated diagnostic device that weighs under a pound, costs as little as $100 and can detect Zika, dengue and chikungunya within 30 minutes.

21 Mar 2017

Genetic News and Research

TUM scientists show how diabetes damages small blood vessels around the heart

MSU lands $727,000 NIH grant to improve use of fish as disease models for human medicine

Study compares arm measures to BMI for assessing nutritional status of leukemia survivors

Researchers uncover major clue to how mucus becomes abnormal in CF airways

Genome sequencing approach opens door to therapy options for rare, neglected cancers

Researchers unravel how drug interacts with ribosome to halt protein production

Study finds steady increase in BRCA testing among low-risk women

Researchers develop novel genetic score to calculate age-specific risk of Alzheimer's disease

New genetic biomarker for colon cancer may lead to development of personalized treatment

UC researchers advocate ‘precision medicine’ approach to studying and treating Parkinson's disease

Heroin use linked to epigenetic alterations in the brain

Study shows safety of Schwann cell transplantation for treating subacute thoracic spinal cord injury

New technology may provide non-invasive approach to diagnose and monitor prostate cancer

USC study close to finding gene involved in cleft lip and palate

Study identifies potential Achilles heel of kinase-driven cancers

New study correlates 80 cancer-related gene mutations with 34 AML subgroups

Efficacy of innovative gene therapy can be tested quickly and cost-effectively using new cellular model

Genotype-guided warfarin dosing linked to reduced risk of adverse events

Research findings hold promise to generate blood cell precursors from hPSCs

Sandia researchers develop smartphone-based device to rapidly detect mosquito-borne viruses

Sequencing & Genomics: Elevating Science and Healthcare eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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