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Researchers develop new strategy to treat sickle cell disease and beta thalassemia

Researchers at Dana-Farber/Boston Children's Cancer and Blood Disorders Center and the University of Massachusetts Medical School have developed a strategy to treat two of the most common inherited blood diseases -- sickle cell disease and beta thalassemia -- applying CRISPR-Cas9 gene editing to patients' own blood stem cells.

29 Mar 2019

FDA approves treatment for adults with non-radiographic axial spondyloarthritis

The U.S. Food and Drug Administration today approved Cimzia (certolizumab pegol) injection for treatment of adults with a certain type of inflammatory arthritis called non-radiographic axial spondyloarthritis (nr-axSpA), with objective signs of inflammation. This is the first time that the FDA has approved a treatment for nr-axSpA.

28 Mar 2019

Lab-grown blood vessels provide hope for dialysis patients

Research published this week describes how lab-grown blood vessels were transformed into living tissue when grafted into dialysis patients needing replacement blood vessels.

28 Mar 2019

Researchers describe mathematical model as key to developing effective drugs for brain disorders

A collaboration between researchers from the UAB Institute of Neurosciences and the pharmaceutical company GlaxoSmithKline, published in March in Trends in Pharmacological Sciences, describes a mathematical model to quantify the activity of biased G-protein-coupled receptors.

28 Mar 2019

Gene transfer technique can combat diabetes-linked heart dysfunction

Researchers with the VA San Diego Healthcare System and the University of California San Diego have shown that a gene transfer technique can combat heart dysfunction caused by diabetes.

28 Mar 2019

New discovery may explain low testosterone levels in men with diabetes

Scientists have mapped out how the body transports testosterone, and their surprising findings may explain low testosterone levels seen in men with diabetes or patients on certain medications.

28 Mar 2019

Producing human protein in CHO-cells can eliminate the need for blood donors

Alpha-1-antitrypsin is a protein produced by the liver. The protein gets secreted to the blood stream, where it circulates the body to protect the lungs.

28 Mar 2019

Radiolabeled protein lights up tumor to reveal where cancer drugs are working

Experimenting with mice, Johns Hopkins researchers report they have successfully used positron emission tomography scans to calculate in real time how much of an immunotherapy drug reaches a tumor and what parts of a cancer remain unaffected.

28 Mar 2019

Using gene therapy strategies to rejuvenate aging cells and treat osteoarthritis

Aging is a risk factor for the development of osteoarthritis (OA), a chronic disease characterized by degeneration of articular cartilage leading to pain and physical disability.

28 Mar 2019

Just one dose of glucose while on keto diet can damage blood vessels

The often embraced 'cheat day' is a common theme in many diets and the popular ketogenic diet is no exception. But new research from UBC's Okanagan campus says that just one 75-gram dose of glucose--the equivalent a large bottle of soda or a plate of fries--while on a high fat, low carbohydrate diet can lead to damaged blood vessels.

28 Mar 2019

Study describes new muscular disease caused by mutation in myoglobin gene

Researchers of the Bellvitge Biomedical Research Institute led by Dr. Montse Olivé have described in Nature Communications a new muscular disease caused by a mutation in the myoglobin gene.

28 Mar 2019

Exercise helps prevent cartilage degradation caused by osteoarthritis, study shows

Exercise helps to prevent the degradation of cartilage caused by osteoarthritis, according to a new study from Queen Mary University of London.

27 Mar 2019

Researchers identify crucial player in controlling misfolded proteins

Researchers have identified a protein complex that marks misfolded proteins, stops them from interacting with other proteins in the cell and directs them towards disposal.

27 Mar 2019

C-Path and Japan's PMDA join forces on first-of-its-kind biomarker project

Critical Path Institute announced today that a formal consultation between its Predictive Safety Testing Consortium and Japan's Pharmaceuticals and Medical Devices Agency has resulted in an agreement on a first-of-its-kind approach to compare the levels of eight novel urinary kidney safety biomarkers in healthy Japanese volunteers to data collected on these same biomarkers in healthy Western volunteers in a bridging study.

27 Mar 2019

Researchers discover underlying cause of hereditary muscle disease

Researchers at Karolinska Institutet have discovered the underlying cause of a hereditary muscle disease first characterised in a Swedish family in 1980. It proves to be the first identified disease caused by defective myoglobin, the protein that transports oxygen in muscle cells.

27 Mar 2019

Probing Submicron Protein Aggregation using Asymmetrical Flow Field-Flow Fractionation, AF4, and Light Scattering

The most recent developments by Wyatt in their instrumentation and software have made the full potential of FFF accessible to a wider user base. In this interview, Kim R. Williams and Christoph Johann talk to News-Medical and Life Sciences about the technologies and their research.

From Waters | Wyatt Technology 27 Mar 2019

Autophagy can help combat Salmonella and other pathogens

Autophagy - the process of recycling cellular material in the body, can help combat Salmonella and other pathogens according to researchers at the School of Life Sciences, University of Warwick who have studied how autophagy can get rid of bacteria, and prevent diseases developing.

27 Mar 2019

Researchers unravel biomechanics of Ebola virus-host cell adhesion

It was recently reported that the number of Ebola cases in the Democratic Republic of Congo has surpassed 1,000, making it the second-worst outbreak in history after the 2014 outbreak in West Africa in which 29,000 people were infected and more than 11,000 died.

27 Mar 2019