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How body's first line of defence distinguishes between microbes and own structures

This week, the highly-respected US Academy of Sciences journal (PNAS) published an article describing how the first line of defence of the human immune system distinguishes between microbes and the body's own structures.

4 Feb 2011

Cholesterol efflux capacity may protect against heart disease: Study

The discovery that high levels of high-density lipoprotein cholesterol are associated with reduced risk of cardiovascular disease has fostered intensive research to modify HDL levels for therapeutic gain. However, recent findings have called into question the notion that pharmacologic increases in HDL cholesterol levels are necessarily beneficial to patients.

4 Feb 2011

Scientists reprogram marrow cells from patient with chronic myeloid leukemia

By coaxing healthy and diseased human bone marrow to become embryonic-like stem cells, a team of Wisconsin scientists has laid the groundwork for observing the onset of the blood cancer leukemia in the laboratory dish.

4 Feb 2011

Immune protein exacerbates skin cancer due to sun exposure: Study

An unexpected immune protein exacerbates cancer due to sun exposure, report researchers in the January 27th issue of Nature. The study suggests that drugs blocking the protein might halt tumor growth in skin cancer patients.

3 Feb 2011

IDF commends Florida council for recommending SCID screening for all newborns

The Florida Genetics and Newborn Screening Program Advisory Council voted unanimously to recommend that the Department of Health screen all newborns for Severe Combined Immune Deficiency (SCID) – commonly known as bubble boy disease.

3 Feb 2011

Scientists discover breast cancer cells that dodge immune system, promote tumor growth

Scientists discovered a new way breast cancer cells dodge the immune system and promote tumor growth, providing a fresh treatment target in the fight against the disease. While comparable mechanisms to avoid the immune system have been identified in mice with breast and other cancers, the study tested human breast tumor cells, putting researchers closer to understanding how the disease progresses in real patients.

2 Feb 2011

New compound appears to prevent pain crises in sickle cell disease: GHSU

A new compound appears to prevent the traffic jam of cells that causes debilitating pain crises and associated mortality in sickle cell disease, Georgia Health Sciences University researchers report.

1 Feb 2011

Researchers discover 'common set of dysregulated miRNAs in murine lupus models'

Potentially impacting future diagnosis and treatment of lupus, an immune illness affecting more than 5 million people worldwide, researchers at the Virginia-Maryland Regional College of Veterinary Medicine at Virginia Tech have likely uncovered where the breakdown in the body's lymphocyte molecular regulatory machinery is occurring.

1 Feb 2011

Histamine can be an important molecule to develop new treatments for MS

If you think histamines are your nemesis during allergy season, here's something that might change your perspective. New research published in the Journal of Leukocyte Biology shows that histamine could be an important molecule to developing new treatments for multiple sclerosis.

1 Feb 2011

Prototype drug halts GVHD in mouse models of bone marrow transplantation

A prototype drug already shown to hold promise for treating autoimmune disorders like lupus, arthritis and psoriasis halts established graft-versus-host disease (GVHD) in mouse models of bone marrow transplantation, research at the University of Michigan and the University of Florida shows.

28 Jan 2011

Study suggests newborn diagnosis can improve survival in SCID patients

Severe Combined Immunodeficiency occurs in just one out of every 50,000 to 100,000 births in the United States, yet it is the most serious primary immunodeficiency disorder. A study published today in Blood, the Journal of the American Society of Hematology, demonstrates that babies with SCID who are diagnosed at birth and receive a hematopoietic stem cell transplant, which is the transplantation of blood-forming stem cells, have significantly improved survival.

28 Jan 2011

Study: Removal of B lymphocytes can reverse aging process

Researchers at the Technion-Israel Institute of Technology have discovered a way to reverse the aging process by removing old B lymphocytes from old mice, and forcing the production of young, potent cells to replace them.

27 Jan 2011

Senesco files SNS01-T IND for treatment of multiple myeloma

Senesco Technologies, Inc. today announced that the Company has filed an Investigational New Drug application with the U.S. Food and Drug Administration for Senesco's lead drug candidate SNS01-T for treatment of multiple myeloma.

24 Jan 2011

Breakthrough in understanding mechanisms behind hereditary alpha-1-antitrypsin deficiency

Researchers from the Royal College of Surgeons in Ireland (RCSI) and Beaumont Hospital have made a breakthrough in understanding the mechanisms behind the most severe form of hereditary emphysema and how protein treatments can improve the condition. The findings of this study may also lead to new treatments for patients with smoker's emphysema.

24 Jan 2011

Raptor completes enrollment in DR Cysteamine Phase 3 clinical trial in cystinosis

Raptor Pharmaceutical Corp., today announced it has completed enrollment in its Phase 3 clinical trial of its proprietary delayed-release oral formulation of cysteamine bitartrate ("DR Cysteamine") in patients with nephropathic cystinosis ("cystinosis").

24 Jan 2011

Odontoblast cells are part of immune system, protect teeth from decay: New research

It is known that teeth can protect themselves, to some extent, from attack by bacteria but that inflammation within a tooth can be damaging and, in extreme cases, lead to abscess or death of the tooth. New research published in BioMed Central's open access journal BMC Immunology shows that odontoblast cells are part of the immune system and fight to protect teeth from decay.

23 Jan 2011

Collaborative study may lead to improved influenza vaccine and vaccines for other respiratory virus infections

A collaborative project between researchers at the Trudeau Institute and their colleagues at St. Jude Children's Research Hospital in Memphis, Tenn., offers new insights that may lead to an improved strategy to protect against the influenza virus and other viruses that infect the respiratory tract.

19 Jan 2011

'Master switch' protein in white blood cells linked to inflammation

Scientists have identified a protein that acts as a "master switch" in certain white blood cells, determining whether they promote or inhibit inflammation. The study, published in the journal Nature Immunology, could help researchers look for new treatments for diseases such as rheumatoid arthritis that involve excessive inflammation.

18 Jan 2011

Clinical studies by expert HIV clinicians suggest that HIV-TRePS may have clinical and economic benefits

Two multinational clinical studies indicate that the RDI’s system for predicting how HIV and AIDS patients will respond to different drugs could be a useful tool with potential clinical and economic benefits. The studies, published in the January issue of AIDS Patient Care and STDs, involved highly experienced physicians in the USA, Canada and Italy who used the system to help them select the optimum combination of HIV drugs for patients whose therapy was failing.

18 Jan 2011

Platelet-rich plasma shows a promising biologic treatment for myocardial infarction: Study

Researchers at the Stanford University School of Medicine, in collaboration with BioParadox, Inc., have published data supporting the use of platelet-rich plasma as a promising biologic treatment for myocardial infarction.

18 Jan 2011

Leukocyte News and Research

How body's first line of defence distinguishes between microbes and own structures

Cholesterol efflux capacity may protect against heart disease: Study

Scientists reprogram marrow cells from patient with chronic myeloid leukemia

Immune protein exacerbates skin cancer due to sun exposure: Study

IDF commends Florida council for recommending SCID screening for all newborns

Scientists discover breast cancer cells that dodge immune system, promote tumor growth

New compound appears to prevent pain crises in sickle cell disease: GHSU

Researchers discover 'common set of dysregulated miRNAs in murine lupus models'

Histamine can be an important molecule to develop new treatments for MS

Prototype drug halts GVHD in mouse models of bone marrow transplantation

Study suggests newborn diagnosis can improve survival in SCID patients

Study: Removal of B lymphocytes can reverse aging process

Senesco files SNS01-T IND for treatment of multiple myeloma

Breakthrough in understanding mechanisms behind hereditary alpha-1-antitrypsin deficiency

Raptor completes enrollment in DR Cysteamine Phase 3 clinical trial in cystinosis

Odontoblast cells are part of immune system, protect teeth from decay: New research

Collaborative study may lead to improved influenza vaccine and vaccines for other respiratory virus infections

'Master switch' protein in white blood cells linked to inflammation

Clinical studies by expert HIV clinicians suggest that HIV-TRePS may have clinical and economic benefits

Platelet-rich plasma shows a promising biologic treatment for myocardial infarction: Study

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