Nephropathy News and Research

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Nephropathy is a broad medical term used to denote disease or damage of the kidney, which can eventually result in kidney failure. The primary and most obvious functions of the kidney are to excrete any waste products and to regulate the water and acid-base balance of the body – therefore loss of kidney function is a potentially fatal condition.

Protein adenylyl cyclase senses and regulates pH blood levels

Researchers have identified the protein mechanism that senses bicarbonate fluctuations and adjusts blood pH levels.. A Canadian/U.S. research team led by University of Alberta biological sciences professor, Greg Goss and his graduate students Martin Tresguerres and Scott Parks achieved the first demonstration of the process in a whole animal. The researchers found that the protein adenylyl cyclase sensed and then regulated the pH blood levels in a dogfish shark following feeding.

23 Dec 2009

Darbepoetin alfa does not reduce cardiovascular problem in anemic patients on dialysis

An international study authored by a UT Southwestern Medical Center researcher has concluded that the anemia drug darbepoetin alfa works no better than a placebo in several other applications previously thought to be promising.

22 Dec 2009

GI Dynamics' EndoBarrier non-surgical type 2 diabetes therapy receives European CE mark approval

GI Dynamics, a leader in non-surgical, endoscopic treatments for type 2 diabetes and obesity, today announced that it has received European CE mark approval for the EndoBarrier™, a non-surgical therapy to treat type 2 diabetes and obesity. The CE marking (an acronym for the French "Conformite Europeenne") certifies that a product has met EU requirements for marketing in Europe. Clinical trials involving more than 270 patients have demonstrated the significant weight loss and diabetes improvement achieved with the EndoBarrier Gastrointestinal Liner.

22 Dec 2009

Patients in dialysis centers demonstrated better clinical results after acquired by DaVita, study shows

DaVita Inc., a leading provider of kidney care services for those diagnosed with chronic kidney disease (CKD), today released a study finding patient outcomes in the company’s newly acquired centers showed dramatic improvements over the two years following their switch to DaVita® ownership.

22 Dec 2009

Omega-3 fatty acids lower AMD and chronic kidney disease, improve heart health

Start 2010 right: consume more seafood omega-3 fatty acids. Improvements or lower risks in age-related macular degeneration (AMD), chronic kidney disease and heart health have been reported in people with higher intakes of fatty fish or the omega-3s they contain.

22 Dec 2009

Aristolochic acid in Chinese herbal products associated with increased risk of urinary tract cancer

The carcinogen aristolochic acid, which was found in many prescribed Chinese herbal products including Guan Mu Tong, is associated with an increased risk of urinary tract cancer, according to a new study published online December 21 in the Journal of the National Cancer Institute.

22 Dec 2009

Discovery suggests how toxin-filtering cells go awry

Researchers from Children's Hospital Boston and Brigham and Women's Hospital have identified an important genetic cause of a devastating kidney disease that is the second leading cause of kidney failure in children, according to The NephCure Foundation.

22 Dec 2009

Triage NGAL bedside blood test helps identify AKI risk: New study

According to a new study published last week in Intensive Care Medicine, a novel bedside blood test measured in critically ill patients being admitted to the intensive care unit can help to identify which patients are at risk for acute kidney injury (AKI). The study carried out in Vicenza, Italy, tested blood samples collected during admission to the ICU using the Triage® NGAL Test, a product currently sold by Inverness Medical Innovations, Inc. outside of the United States.

18 Dec 2009

Ambulatory monitoring technique can disturb sleep and raise nighttime blood pressure

A widely used test for measuring nighttime blood pressure may interfere with patients' sleep, thus affecting the results of the test, reports a study in an upcoming issue of Clinical Journal of the American Society of Nephrology (CJASN).

18 Dec 2009

Acute kidney injury associated with increased long-term mortality

Patients with sudden loss of kidney function, called acute kidney injury (AKI), are more likely to die prematurely after leaving the hospital—even if their kidney function has apparently recovered, according to an upcoming study inJournal of the American Society of Nephrology (JASN).

18 Dec 2009

Researchers identify genetic markers to help treat chronic kidney disease among diabetics

Researchers using a DNA analysis tool developed by the Translational Genomics Research Institute (TGen) and UCLA have identified genetic markers that could help treat chronic kidney disease among diabetics.

17 Dec 2009

Researchers develop new electrophoretic method for detecting MIRCERA and EPO in blood

Austrian researchers have successfully developed a new electrophoretic method for detecting MIRCERA® and other erythropoietins (EPO) in the blood. The technique, using SARCOSYL-PAGE, has specifically enhanced sensitivity for MIRCERA, but does not alter the performance characteristics of SDS-PAGE for detecting other EPOs.

16 Dec 2009

Majority of dialysis patients face readmission to acute care facilities, says study

A new study by University of Cincinnati (UC) nephrologists shows that most dialysis patients admitted to long-term care hospitals face readmission to acute care facilities, and those with acute kidney failure don't often recover full kidney function.

15 Dec 2009

By understanding how gene works, scientists may find ways to prevent, cure diabetes

A gene commonly studied by cancer researchers has been linked to the metabolic inflammation that leads to diabetes.

12 Dec 2009

Carotid endarterectomy can benefit patients with chronic kidney disease

Physicians should be comfortable referring some patients with chronic kidney disease (CKD) for effective stroke prevention surgery, according to a study appearing in an upcoming issue of the Journal of the American Society Nephrology (JASN). The findings indicate that CKD patients gain a significant benefit from the procedures without an increased risk of dying from surgical complications.

11 Dec 2009

Acceleron Pharma's ACE-536 stimulates red blood cell production through novel mechanism

Acceleron Pharma, Inc., a biopharmaceutical company developing novel therapeutics that modulate the growth of cells and tissues including red blood cells, bone, muscle, fat, and the vasculature, presented data demonstrating that ACE-536 promotes formation of red blood cells through inhibition of members of the TGF-beta superfamily, at the 51st Annual Meeting of the American Society of Hematology.

8 Dec 2009

People infected with West Nile virus may have persistent virus in their kidneys, shows study

A new study shows that people who have been infected with West Nile virus may have persistent virus in their kidneys for years after initial infection, potentially leading to kidney problems.

8 Dec 2009

Alexion Pharmaceuticals announces positive data from AEGIS study of Soliris

Alexion Pharmaceuticals, Inc. today announced positive data from the 26-week extension of the AEGIS study, an open-label registration study examining Soliris® (eculizumab) for the treatment of Japanese patients with paroxysmal nocturnal hemoglobinuria (PNH).

7 Dec 2009

Norovirus-related illnesses linked to eating oysters, reveals report

The U.S. Food and Drug Administration is advising consumers to avoid eating oysters harvested from the San Antonio Bay on or after Nov. 16 due to reports of norovirus-associated illnesses in some people who had consumed oysters harvested from this area, which is located on the Gulf of Texas.

7 Dec 2009

New tool may allow doctors to predict long-term survival rates of dialysis patients

A new model can help physicians determine if a kidney disease patient on dialysis is likely to die within the next few months, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society Nephrology (CJASN).

4 Dec 2009

Nephropathy News and Research

Further Reading

Protein adenylyl cyclase senses and regulates pH blood levels

Darbepoetin alfa does not reduce cardiovascular problem in anemic patients on dialysis

GI Dynamics' EndoBarrier non-surgical type 2 diabetes therapy receives European CE mark approval

Patients in dialysis centers demonstrated better clinical results after acquired by DaVita, study shows

Omega-3 fatty acids lower AMD and chronic kidney disease, improve heart health

Aristolochic acid in Chinese herbal products associated with increased risk of urinary tract cancer

Discovery suggests how toxin-filtering cells go awry

Triage NGAL bedside blood test helps identify AKI risk: New study

Ambulatory monitoring technique can disturb sleep and raise nighttime blood pressure

Acute kidney injury associated with increased long-term mortality

Researchers identify genetic markers to help treat chronic kidney disease among diabetics

Researchers develop new electrophoretic method for detecting MIRCERA and EPO in blood

Majority of dialysis patients face readmission to acute care facilities, says study

By understanding how gene works, scientists may find ways to prevent, cure diabetes

Carotid endarterectomy can benefit patients with chronic kidney disease

Acceleron Pharma's ACE-536 stimulates red blood cell production through novel mechanism

People infected with West Nile virus may have persistent virus in their kidneys, shows study

Alexion Pharmaceuticals announces positive data from AEGIS study of Soliris

Norovirus-related illnesses linked to eating oysters, reveals report

New tool may allow doctors to predict long-term survival rates of dialysis patients

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