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Scientists discover how a rare genetic disorder disrupts key neural interactions in the developing brain

Every time you chew, talk, yawn, or sense the zap of a toothache, cranial nerve cells are shuttling electrochemical signals to your brain.

23 Feb 2022

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

The role played by the host enzyme TMPRSS2 in infection and cancer is the focus of a new study.

23 Feb 2022

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

In a recent study posted to the Research Square* preprint server, which is under consideration at Scientific Reports, a team of researchers developed a novel human Alveolar Epithelial Lentivirus immortalized (hAELVi) cell infection model to estimate the replication potential of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other respiratory viruses in the lower respiratory tract of humans.

23 Feb 2022

Exploring the potential of mosaic RBD nanoparticles to fight SARS-CoV-2

Researchers explore the potential of mosaic receptor-binding domain nanoparticles in protective immunity against SARS-CoV-2

22 Feb 2022

New method to develop nanoengineered bacteria for photothermal cancer immunotheranostics

There is substantial interest regarding the understanding and designing of nanoengineered bacteria to combat various fatal cancerous diseases.

22 Feb 2022

Study offers a new, effective therapeutic option against glioblastoma

A study recently accepted for publication in The Journal of Clinical Investigation describes a new and effective therapy to treat glioblastoma: the concomitant use of ADI-PEG20 together with focal brain radiotherapy.

22 Feb 2022

Study provides a potent biparatopic antibody against all SARS-CoV-2 variants of concern

Researchers demonstrated the potent neutralization of SARS-CoV-2 VOCs, including Omicron by the biparatopic human heavy chain variable domain.

22 Feb 2022

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

Researchers investigate the potential of picolinic acid (PA) as an anti-SARS-CoV-2 treatment option.

21 Feb 2022

New radio-labeled molecule may allow a non-invasive approach to monitor inflammation in real time

Researchers at The University of Texas MD Anderson Cancer Center have developed a new radio-labeled molecule capable of selectively reacting with certain high-energy radicals that are characteristic of innate immune activity, which may allow a non-invasive approach to monitor inflammation in real time by positron emission tomography (PET) imaging.

21 Feb 2022

Novel ACE2-blocking antibody protects against all SARS-CoV-2 VOCs

Researchers identify 87G7, a SARS-CoV-2 neutralizing human monoclonal antibody with remarkable broad-spectrum neutralization and protection efficacy.

21 Feb 2022

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

Researchers demonstrated the composition and importance of SARS-CoV-2 lipid envelope and assessed the antiviral potential of oral mouthwashes targeting these lipid envelopes.

21 Feb 2022

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

A study posted suggested the inhibition of TBK1 and its homolog KKε could decrease the severity of COVID-19.

21 Feb 2022

Inhalable antibody fragments offer broad protection from SARS-CoV-2 variants

A new study describes a potential new approach to treating COVID-19 in the form of single-chain fragment variable (scFv) antibodies.

20 Feb 2022

Researchers develop novel anti-SARS-CoV-2 Omicron vaccine candidate

Researchers have developed a new vaccine candidate that is specifically targeted against the SARS-CoV-2 Omicron variant.

20 Feb 2022

Structure of protein that can pump toxic molecules out of bacterial cells revealed

MIT chemists have discovered the structure of a protein that can pump toxic molecules out of bacterial cells. Proteins similar to this one, which is found in E. coli, are believed to help bacteria become resistant to multiple antibiotics.

18 Feb 2022

Response of peripheral immune cells to ex vivo SARS-CoV-2 exposure compared to SARS-CoV

Researchers characterized the responses of the PBMCs at the individual cell and cell type levels against SARS-CoV-2 and SARS-CoV ex vivo.

18 Feb 2022

Study finds antigenic profile of Omicron RBD is distinct from the prior SARS-CoV-2 variants of concern

A new study aimed to clarify whether extensive RBD mutations could affect the magnitude and immunodominance hierarchy of the host antibody response.

18 Feb 2022

Exposure to endocrine disrupting mixtures during pregnancy impacts children's brain development

By linking human population studies with experiments in cell and animal models, researchers have provided evidence that complex mixtures of endocrine disrupting chemicals impact children's brain development and language acquisition.

17 Feb 2022

Ensitrelvir, a novel SARS-CoV-2 antiviral

S-217622 reduces the viral load and help alleviate the severity of SARS-CoV-2 in infected hamsters.

17 Feb 2022

Study examines lyophilized mRNA-lipid nanoparticle vaccines with long-term stability

A new study explored the high immunogenicity and stability of lyophilized mRNA-LNP vaccines in relation to SARS-CoV-2.

16 Feb 2022

in vivo News and Research

Scientists discover how a rare genetic disorder disrupts key neural interactions in the developing brain

Study demonstrates that TMPRSS2, which is key to SARS-CoV-2 cell entry, is a tumor suppressor

hAELVi cell infection model mimics SARS-CoV-2 Omicron infection in lower respiratory tract of humans

Exploring the potential of mosaic RBD nanoparticles to fight SARS-CoV-2

New method to develop nanoengineered bacteria for photothermal cancer immunotheranostics

Study offers a new, effective therapeutic option against glioblastoma

Study provides a potent biparatopic antibody against all SARS-CoV-2 variants of concern

Broad-spectrum antiviral activity of picolinic acid against SARS-CoV-2 and Influenza A virus

New radio-labeled molecule may allow a non-invasive approach to monitor inflammation in real time

Novel ACE2-blocking antibody protects against all SARS-CoV-2 VOCs

Surfactant-containing oral mouthwashes target the lipid envelope of SARS-CoV-2

Study suggests non-classical inhibition of TBK1/IKKε is protective against severe COVID-19 immunopathology in vivo

Inhalable antibody fragments offer broad protection from SARS-CoV-2 variants

Researchers develop novel anti-SARS-CoV-2 Omicron vaccine candidate

Structure of protein that can pump toxic molecules out of bacterial cells revealed

Response of peripheral immune cells to ex vivo SARS-CoV-2 exposure compared to SARS-CoV

Study finds antigenic profile of Omicron RBD is distinct from the prior SARS-CoV-2 variants of concern

Exposure to endocrine disrupting mixtures during pregnancy impacts children's brain development

Ensitrelvir, a novel SARS-CoV-2 antiviral

Study examines lyophilized mRNA-lipid nanoparticle vaccines with long-term stability

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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