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Researchers devise strategies to target glioma stem cells that could improve patient survival

Glioblastoma multiforme is the most common and aggressive primary brain tumor and has one of the worst survival rates of all cancers.

5 Feb 2018

Early and targeted treatment of dnDSA preserves allograft function

Development of de novo donor-specific antibodies (dnDSA) is known to cause graft failure. Therefore, a protocol aimed at prospective monitoring and treating dnDSA--before it can cause graft damage--was developed for kidney transplant recipients at Children National Health System.

5 Feb 2018

Researchers receive major boost to explore long-standing paradigm in endocrinology

A team of researchers at the University of California, Riverside, seeking to upend a long-held theory explaining how hormones freely enter and exit cells, has received a major boost in the form of a $1 million award from the W. M. Keck Foundation.

5 Feb 2018

Moffitt study identifies new drug target that may reduce GVHD risk

Stem cell transplants can cure patients with high-risk leukemia or lymphoma. Graft-versus-host disease is a potentially life-threatening side effect that occurs when the donor's immune cells attack the recipient's normal tissues.

5 Feb 2018

Weight loss surgery helps prevent diabetes-related microvascular complications in obese patients

In a BJS analysis of published studies in obese patients with type 2 diabetes, researchers found that weight loss surgery helps prevent the development of microvascular complications—which affect small blood vessels—better than medical treatment.

5 Feb 2018

Ribosomes found to be cause of somatic cell pluripotency

In 2012, a Japanese research group discovered that human skin cells acquire pluripotency when introduced to lactic acid bacteria. Now, the same group of researchers have found that the cause of somatic cell conversion into pluripotent stem cells is the ribosome, a protein synthesizing cellular organelle.

5 Feb 2018

Multinational companies continue to manufacture unapproved formulations in India, research finds

Millions of unapproved antibiotics are being sold in India, according to a new study by researchers at Queen Mary University of London and Newcastle University.

5 Feb 2018

Extending dosing intervals makes common multiple sclerosis drug safer to use

A commonly-prescribed multiple sclerosis (MS) infusion medication linked to a rare but serious side effect is safer to use when dosing intervals are extended, according to a new study led by MS specialists NYU Langone Health.

5 Feb 2018

Researchers use innovative method to screen kinases for cancer drug's effectiveness

In recent years, a powerful suite of drugs known as kinase inhibitors have been developed to treat cancer and other diseases. Primary targets of such drugs include a family of receptor tyrosine kinases (RTKs) which protrude from cell surfaces like antennae and can activate cancer-related pathways in virtually all types of cancer when signaling molecules bind with them.

5 Feb 2018

Study uncovers potential targets for treatment of aggressive triple-negative breast cancers

As part of a breast-cancer diagnosis, doctors analyze the tumor to determine which therapies might best attack the malignancy.

2 Feb 2018

Scientists synthesize new multifunctional compound that has anti-tumor properties

A research team of the UNN Faculty of Chemistry led by Professor Alexei Fedorov has developed and synthesized a new multifunctional compound that possesses anti-tumor properties that are due to several independent effects.

2 Feb 2018

Real-time information about stamp bags could serve as early warning of new illegal drugs

In just two years, the powerful opioid fentanyl went from nonexistent to detected in more than 1 in 7 stamp bags analyzed by the Allegheny County Office of the Medical Examiner, according to an analysis led by the University of Pittsburgh Graduate School of Public Health. Stamp bags are small wax packets that contain mixtures of illicit drugs, most commonly heroin, packaged for sale and sometimes stamped with a graphical logo by drug dealers to market their contents.

2 Feb 2018

Scientists develop immune-stimulating injections against cancer

A team of researchers have developed two immune-stimulating injections, that removed all traces of cancer when injected directly into solid mouse tumors.

2 Feb 2018

Geneva researchers highlight new way to control tumor progression

For a tumor to grow, it must develop blood vessels that supply nutrients and oxygen. Preventing tumor vascularization is therefore an interesting anti-tumor therapy that has been explored over the last ten years.

2 Feb 2018

New modular platform offers robust biological approach that targets endless number of diseases

The biological complexity of cancer and other diseases demands a more formidable arsenal of therapies than currently available. Most therapeutic approaches ignore the dynamic molecular network of genes, targeting instead only very few selected disease-related genes.

1 Feb 2018

New clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy

An international group of clinicians and scientists representing the Clinical Pharmacogenetics Implementation Consortium published the first-ever clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy in Clinical Pharmacology and Therapeutics.

1 Feb 2018

Two bacterial species collaborate to drive development of colon cancers

Patients with an inherited form of colon cancer harbor two bacterial species that collaborate to encourage development of the disease, and the same species have been found in people who develop a sporadic form of colon cancer, a study led by a Johns Hopkins Bloomberg~Kimmel Institute for Cancer Immunotherapy research team finds.

1 Feb 2018

Drugs News and Research

Researchers devise strategies to target glioma stem cells that could improve patient survival

Early and targeted treatment of dnDSA preserves allograft function

Researchers receive major boost to explore long-standing paradigm in endocrinology

Moffitt study identifies new drug target that may reduce GVHD risk

Weight loss surgery helps prevent diabetes-related microvascular complications in obese patients

Ribosomes found to be cause of somatic cell pluripotency

Multinational companies continue to manufacture unapproved formulations in India, research finds

Extending dosing intervals makes common multiple sclerosis drug safer to use

Researchers use innovative method to screen kinases for cancer drug's effectiveness

Study uncovers potential targets for treatment of aggressive triple-negative breast cancers

Scientists synthesize new multifunctional compound that has anti-tumor properties

Real-time information about stamp bags could serve as early warning of new illegal drugs

Scientists develop immune-stimulating injections against cancer

Geneva researchers highlight new way to control tumor progression

New modular platform offers robust biological approach that targets endless number of diseases

New clinical practice guideline for using CYP2D6 genotype to guide tamoxifen therapy

Two bacterial species collaborate to drive development of colon cancers

Exploring the Future of Breast Cancer Risk Assessment

Scientists decipher molecular structure of antipsychotic docked in its key receptor

Food preservative improves symptoms in antipsychotic-resistant schizophrenia patients

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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