Animal Model News and Research

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New animal model provides insight into early stages of Parkinson's disease

At the present, no cure exists for Parkinson's disease, although symptomatic intervention, including treatment with dopamine agonists, can alleviate patients' motor impairment. Parkinson's is the second most common neurodegenerative disorder, after Alzheimer's disease; it is estimated that 100,000 to 300,000 patients are affected by Parkinson's disease in Germany alone.

28 May 2013

UC Davis scientists detect novel molecular target for multiple sclerosis

Working with lab mice models of multiple sclerosis, UC Davis scientists have detected a novel molecular target for the design of drugs that could be safer and more effective than current FDA-approved medications against MS.

17 May 2013

LMU researchers reveal link between natural killer cells and hematopoiesis

Infections can trigger hematopoiesis at sites outside the bone marrow - in the liver, the spleen or the skin. Researchers at Ludwig-Maximilians-Universitaet in Munich now show that a specific type of immune cell facilitates such "extra medullary" formation of blood cells.

16 May 2013

Study suggests that a blood protein contributes to early development of atherosclerosis

It's on Saturday that the Journal of the American Heart Association published the conclusive results from a study directed by Dr. Éric Thorin of the Montreal Heart Institute (MHI), which suggests for the first time that a blood protein contributes to the early development of atherosclerosis.

14 May 2013

IDIBELL signs patent licensing agreement with Minoryx

The Bellvittge Biomedical Research Institute has signed a licensing agreement with the Spanish biotechnology company Minoryx of a patent for the treatment of X-linked adrenoleukodystrophy, a rare serious neurodegenerative disease which has no effective treatment.

8 May 2013

Scientists spell out pivotal role of Peli1 in mouse model of multiple sclerosis

Scientists have identified an influential link in a chain of events that leads to autoimmune inflammation of the central nervous system in a mouse model of multiple sclerosis.

3 May 2013

GS-9620 therapy suppresses hepatitis B virus infection

A novel drug developed by Gilead Sciences and tested in an animal model at the Texas Biomedical Research Institute in San Antonio suppresses hepatitis B virus infection by stimulating the immune system and inducing loss of infected cells.

29 Apr 2013

Novel approach using Listeria bacteria shows promise against metastatic pancreatic cancer

Researchers at Albert Einstein College of Medicine of Yeshiva University have developed a therapy for pancreatic cancer that uses Listeria bacteria to selectively infect tumor cells and deliver radioisotopes into them.

25 Apr 2013

Dietary substitution of saturated fats enriched in MCT prevents liver disease

Scientists at the Arkansas Children's Nutrition Center, a U.S. Department of Agriculture Agricultural Research Service Human Nutrition Research Center at the University of Arkansas for Medical Sciences, led by Dr. Martin Ronis have determined that dietary substitution of saturated fats enriched in medium chain triglycerides (MCT) for polyunsaturated fat prevents the development of nonalcoholic fatty liver disease (NAFLD).

25 Apr 2013

Individuals with MEN1 are at increased risk of developing neuroendocrine tumors

A mutation in a protein called menin causes a hereditary cancer syndrome called MEN1 (multiple endocrine neoplasia type 1).

25 Apr 2013

Investigational treatment for ALS passes early phase clinical trial for safety

An investigational treatment for an inherited form of Lou Gehrig's disease has passed an early phase clinical trial for safety, researchers at Washington University School of Medicine in St. Louis and Massachusetts General Hospital report.

24 Apr 2013

Therapy originally conceived for cancer could hold promise for weight loss, say researchers

Researchers have long known that cancerous tumors grow collections of abnormal blood cells, the fuel that feeds this disease and keeps it growing. Now, new evidence in an animal model suggests that blood vessels in the fat tissue of obese individuals could provide the same purpose-and could provide the key to a new way for people to lose weight.

24 Apr 2013

Experimental drug can reduce breast-cancer aggressiveness, restore drug-sensitivity

A new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) suggests that an unusual experimental drug can reduce breast-cancer aggressiveness, reverse resistance to the drug fulvestrant and perhaps improve the effectiveness of other breast-cancer drugs.

23 Apr 2013

Research shows respiratory syncytial virus can be transferred during pregnancy to unborn baby

The most common cause of lower respiratory tract infections in infants and young children, respiratory syncytial virus (RSV), can be transferred during pregnancy to an unborn baby, according to Cleveland Clinic Children's Hospital research published online this week in the journal PLOS ONE.

19 Apr 2013

Animal Model News and Research

New animal model provides insight into early stages of Parkinson's disease

UC Davis scientists detect novel molecular target for multiple sclerosis

LMU researchers reveal link between natural killer cells and hematopoiesis

Study suggests that a blood protein contributes to early development of atherosclerosis

IDIBELL signs patent licensing agreement with Minoryx

Scientists spell out pivotal role of Peli1 in mouse model of multiple sclerosis

GS-9620 therapy suppresses hepatitis B virus infection

Novel approach using Listeria bacteria shows promise against metastatic pancreatic cancer

Dietary substitution of saturated fats enriched in MCT prevents liver disease

Individuals with MEN1 are at increased risk of developing neuroendocrine tumors

Investigational treatment for ALS passes early phase clinical trial for safety

Therapy originally conceived for cancer could hold promise for weight loss, say researchers

Experimental drug can reduce breast-cancer aggressiveness, restore drug-sensitivity

Research shows respiratory syncytial virus can be transferred during pregnancy to unborn baby

Research findings in mice may pave way towards understanding autism in human patients

Researchers unravel dual role of tumor necrosis factor in TB

Baylor University study shows acute dose of alcohol may cause greater impairment in elderly

Preclinical study of cabozantinib in prostate cancer bone metastasis model presented at AACR meeting

Phase I results show Rogosertib is well tolerated in patients with advanced solid tumors

Study evaluates efficacy of drug combinations in treating colorectal cancer

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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