Cell Death News and Research

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Strongest genetic risk factor for Alzheimer’s disease impairs function of human microglia

A study carried out with a new human stem cell-derived model reveals that the most prevalent genetic risk factor of Alzheimer’s disease (AD), apolipoprotein E4 (APOE4), impairs the function of human brain immune cells, microglia. These findings pave the way for new, effective treatment approaches for AD. The results were published in Stem Cell Reports.

17 Sep 2019

New method developed to address failures in promising anti-cancer drug

Biomedical engineers at Duke University have developed a method to address failures in a promising anti-cancer drug, bringing together tools from genome engineering, protein engineering and biomaterials science to improve the efficacy, accuracy and longevity of certain cancer therapies.

17 Sep 2019

Scientists identify molecule that plays key role in determining fate of cells under stress

St. Jude Children's Research Hospital scientists have identified a molecule that plays a pivotal role in determining the fate of cells under stress, much like a Roman emperor deciding the fate of gladiators in the coliseum.

12 Sep 2019

LMRI scientists discover cause of debilitating eye disease

Scientists at the Lowy Medical Research Institute have discovered one cause of a progressive, debilitating eye disease called macular telangiectasia type 2 (MacTel).

11 Sep 2019

Genetic engineering could open possibilities for patients with Parkinson’s disease

People with Parkinson’s disease experience loss of dopamine-producing brain cells, leading to tremors, rigidity, bradykinesia, and postural instability, the primary symptoms of the disease.

11 Sep 2019

Antioxidant compound proves effective in kidney ischemia-reperfusion treatment

Russian researchers from the Moscow Institute of Physics and Technology, the Institute of Cell Biophysics, and elsewhere have shown an antioxidant compound known as peroxiredoxin to be effective in treating kidney injury in mice.

9 Sep 2019

Nanoparticles activated by X rays used to target deep tumours

A team of researchers from University of Texas at Arlington, University of Rhode Island and Brown University have collaborated to come up with use of nanoparticles in targeted therapy for deep seated cancers. Their success with the nanoparticples was published in a study titled, “X-ray induced photodynamic therapy with copper-cysteamine nanoparticles in mice tumors,” was published in the latest issue of the journal Proceedings of the National Academy of Sciences.

8 Sep 2019

UAB researchers identify biomarker for early beta cell death in Type 1 diabetes

Beta cells in the pancreas produce insulin. Their death is a key feature of Type 1 diabetes, and that loss starts long before diagnosis. However, there has been no straightforward way to measure that early loss.

8 Sep 2019

Researchers discover potential of antihistamines that cause death of leukemic stem cells

Ruth M. Risueño leads the Leukaemic Stem Cell group of the Josep Carreras Leukaemia Research Institute. This group investigates Acute Myeloid Leukemia and the cell population responsible for the disease spreading, persisting, and if it has been treated and overcome, reappear.

6 Sep 2019

Resistance to 'hunger hormone' linked with cognitive impairments and memory loss

Scientists at The University of Texas at Dallas have found evidence suggesting that resistance to the "hunger hormone" ghrelin in the brain is linked to the cognitive impairments and memory loss associated with Alzheimer's disease.

4 Sep 2019

Study reshapes the understanding of telomerase's function in normal cells

New research from the University of Maryland and the National Institutes of Health reveals a new role for the enzyme telomerase.

3 Sep 2019

Paracetamol poisoning soars over the past decade in Australia

Paracetamol is one of the most common painkillers and antipyretics used in Australia. However, a new study hopes for the restriction in the access to the drug, due to a serious spike in paracetamol poisonings.

2 Sep 2019

New molecules that could help tackle tooth loss and regeneration discovered

Our teeth take thousands of bites per day, and understanding exactly what holds them in place and how is key to helping people live with their own teeth for longer.

30 Aug 2019

KAIST researchers describe new mechanism that induces self-killing of cancer cells

Researchers have described a new mechanism which induces the self-killing of cancer cells by perturbing ion homeostasis. A research team from the Department of Biochemical Engineering has developed helical polypeptide potassium ionophores that lead to the onset of programmed cell death.

29 Aug 2019

Potential drug could revolutionize the treatment of neurological conditions

The international team of scientists from Gero Discovery LLC, the Institute of Biomedical Research of Salamanca, and Nanosyn, Inc. has found a potential drug that may prevent neuronal death through glucose metabolism modification in stressed neurons.

28 Aug 2019

UTA receives CPRIT funding to support cancer research programs

The University of Texas at Arlington received more than $2.1 million in grants from the Cancer Prevention & Research Institute of Texas to support the University's flourishing cancer research programs.

28 Aug 2019

New therapy may kill cancer cells in inherited breast cancer

Breast cancer begins when the cells in the breast begin to grow out of control. The cells form a tumor, which can become malignant if they invade and spread to surrounding tissues. Like any other cancers, breast cancer has many risk factors that can’t be changed, like family history.

28 Aug 2019

Gold nanoparticles shown to safely, effectively ablate low- to intermediate-grade prostate tumors

Biocompatible gold nanoparticles designed to convert near-infrared light to heat have been shown to safely and effectively ablate low- to intermediate-grade tumors within the prostate, according to a study conducted at the Icahn School of Medicine and published in the journal Proceedings of the National Academy of Sciences.

27 Aug 2019

Genetically altering protein in colon cancer cells may enhance efficacy of chemotherapy

Colorectal cancer outcomes may improve by genetically altering an immune-regulatory protein in cancer cells, making the cells more vulnerable to chemotherapy. That's according to new Mayo Clinic research.

27 Aug 2019

Researchers target cancer's protective barrier

Cancer cells are notorious for their camouflage work, which enables them to escape immune targeting. Now scientists are learning how to strip away the disguise and allow the immune system to do its work, by targeting cells called myeloid-derived suppressor cells (MDSCs) that shield the tumor. This would also enhance the effectiveness of newer cancer immunotherapies like Chimeric-Antigen Receptor T cell (CAR-T).

26 Aug 2019

Cell Death News and Research

Strongest genetic risk factor for Alzheimer’s disease impairs function of human microglia

New method developed to address failures in promising anti-cancer drug

Scientists identify molecule that plays key role in determining fate of cells under stress

LMRI scientists discover cause of debilitating eye disease

Genetic engineering could open possibilities for patients with Parkinson’s disease

Antioxidant compound proves effective in kidney ischemia-reperfusion treatment

Nanoparticles activated by X rays used to target deep tumours

UAB researchers identify biomarker for early beta cell death in Type 1 diabetes

Researchers discover potential of antihistamines that cause death of leukemic stem cells

Resistance to 'hunger hormone' linked with cognitive impairments and memory loss

Study reshapes the understanding of telomerase's function in normal cells

Paracetamol poisoning soars over the past decade in Australia

New molecules that could help tackle tooth loss and regeneration discovered

KAIST researchers describe new mechanism that induces self-killing of cancer cells

Potential drug could revolutionize the treatment of neurological conditions

UTA receives CPRIT funding to support cancer research programs

New therapy may kill cancer cells in inherited breast cancer

Gold nanoparticles shown to safely, effectively ablate low- to intermediate-grade prostate tumors

Genetically altering protein in colon cancer cells may enhance efficacy of chemotherapy

Researchers target cancer's protective barrier

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