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Dietary antigens reduce small intestine cancer by boosting immune T-cells

Study shows that dietary antigens can suppress small intestine carcinogenesis by activating T-cells through Peyer's patches. Adding bovine serum albumin (BSA) or ovalbumin (OVA) to antigen-free diets restored immune function and reduced tumor growth in mice.

22 Sep 2024

Sexual health symptoms associated with lower adherence to breast cancer therapy in Black women

Among patients with early-stage breast cancer treated with adjuvant endocrine therapy (AET), symptoms related to sexual health were associated with decreased adherence to treatment in Black women, according to results presented at the 17th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, held September 21-24, 2024.

21 Sep 2024

Bariatric surgery outperforms GLP-1 medications in protecting kidney function

A Cleveland Clinic study showed that in patients with type 2 diabetes, obesity, and chronic kidney disease, bariatric surgery was associated with a significant decrease in the progression of chronic kidney disease compared to those who received GLP-1 diabetes medications. The paper was published in Annals of Surgery.

20 Sep 2024

Study reveals distinct brain pathways for decision-making in primates

In a constantly changing world, animals, including humans, need to quickly adapt to their environment and learn to make decisions that lead to the best possible outcomes.

20 Sep 2024

Lipid metabolism plays a critical role in red blood cell recovery from acute anemia

Red blood cells are the most abundant cells in the body. It has long been known that when red blood cells break down or anemia occurs due to bleeding, the hormone erythropoietin (EPO) increases, leading to the proliferation of immature cells (erythroblasts) that eventually become red blood cells, thus restoring the red blood cell count.

20 Sep 2024

Hypothalamic ECM remodeling drives insulin resistance, contributing to obesity and diabetes

Researchers have discovered that remodeling of extracellular matrix (ECM) in the hypothalamus, specifically around AgRP neurons, drives insulin resistance and metabolic disease. Disrupting this ECM buildup improves insulin sensitivity and may be a promising treatment for obesity and diabetes.

19 Sep 2024

FORT-2 trial shows promising results for bladder cancer immunotherapy combination

Findings from the international FORT-2 clinical trial showed that a combination treatment including immunotherapy is safe and tolerable in patients with locally advanced or metastatic bladder cancer.

19 Sep 2024

Cardiovascular disease pathways associated with psoriasis, but not other immune-mediated diseases

A genetic connection between cardiovascular disease and psoriasis highlights shared inflammatory pathways, emphasizing the need for cardiovascular monitoring.

19 Sep 2024

Researchers uncover receptor that dampens sensory input

Signals in our brain are not always processed in the same way: Certain receptors modulate these mechanisms, influencing our mood, perception, and behavior in various ways. One of these is the 5-HT2A receptor, which has a recently discovered unique characteristic.

18 Sep 2024

Leptin variations may influence brain health and dementia development

New research is more closely linking obesity to dementia. Higher levels of leptin, a hormone that helps maintain normal body weight, is associated with better signal-transmitting brain white matter in middle-aged adults, according to a study by The University of Texas Health Science Center at San Antonio (UT Health San Antonio).

18 Sep 2024

Researchers discover how rare cell type controls scar tissue formation in spinal cord injuries

After a spinal cord injury, nearby cells quickly rush to action, forming protective scar tissue around the damaged area to stabilize and protect it.

18 Sep 2024

Study helps explain why having ApoE4 increases risk of neurodegeneration

A new study helps explain why having ApoE4—the gene variant most closely linked to Alzheimer's disease—increases the risk of neurodegeneration and white matter damage.

18 Sep 2024

Extended estrogen suppression treatment found safe for postmenopausal breast cancer patients

New evidence shows that extended estrogen suppression treatment using an aromatase inhibitors for hormone receptor-positive postmenopausal breast cancer is safe; it does not increase the risk of coronary artery calcification, a sign of active coronary atherosclerosis, as some prior studies had indicated.

18 Sep 2024

Study paves way for revolutionizing the management of muscle disorders

The type 1 ryanodine receptor (RyR1) is an important calcium release channel in skeletal muscles essential for muscle contraction.

18 Sep 2024

Newly discovered mechanism could revolutionize infertility care by promoting embryo implantation

A team from Kumamoto University has uncovered a new mechanism that could revolutionize infertility care by promoting embryo implantation.

18 Sep 2024

Researchers discover how oral cancer cells may block the body's immune response

Macquarie University researchers have discovered new information about how oral cancer cells may block the body's immune response. This could lead to better treatments for this aggressive disease.

18 Sep 2024

$1 million grant awarded to explore myelin repair mechanisms in multiple sclerosis

The National Multiple Sclerosis Society (USA) has awarded a grant of 1 million dollars to Dr. Isabel Pérez-Otaño, who leads the Plasticity and Remodeling of Neural Circuits laboratory at the Institute for Neurosciences (IN), a joint center of the Spanish National Research Council (CSIC) and the Miguel Hernández University (UMH) of Elche.

18 Sep 2024

Receptor News and Research

Dietary antigens reduce small intestine cancer by boosting immune T-cells

Sexual health symptoms associated with lower adherence to breast cancer therapy in Black women

Bariatric surgery outperforms GLP-1 medications in protecting kidney function

Study reveals distinct brain pathways for decision-making in primates

Lipid metabolism plays a critical role in red blood cell recovery from acute anemia

Hypothalamic ECM remodeling drives insulin resistance, contributing to obesity and diabetes

FORT-2 trial shows promising results for bladder cancer immunotherapy combination

Cardiovascular disease pathways associated with psoriasis, but not other immune-mediated diseases

Researchers uncover receptor that dampens sensory input

Leptin variations may influence brain health and dementia development

Researchers discover how rare cell type controls scar tissue formation in spinal cord injuries

Study helps explain why having ApoE4 increases risk of neurodegeneration

Extended estrogen suppression treatment found safe for postmenopausal breast cancer patients

Study paves way for revolutionizing the management of muscle disorders

Newly discovered mechanism could revolutionize infertility care by promoting embryo implantation

Researchers discover how oral cancer cells may block the body's immune response

$1 million grant awarded to explore myelin repair mechanisms in multiple sclerosis

Impact of oxidative stress, gut, and diet on attention deficit hyperactivity disorder pathophysiology

Long COVID patients maintain robust immune memory two years after infection

Study reveals higher breast cancer mortality risk for black women across all tumor types

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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