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Researchers discover internal body scales that regulate fat mass

Researchers at Sahlgrenska Academy, University of Gothenburg, Sweden, have found evidence for the existence of an internal body weight sensing system.

27 Dec 2017

Reduced activity of transcription factor plays key role in triggering pulmonary fibrosis

To date, the molecular basis of pulmonary fibrosis has been poorly understood. Scientists from the Max Planck Institute for Heart and Lung Research in Bad Nauheim have now shown that reduced activity of the transcription factor FoxO3 plays a key role in the development of the disease.

26 Dec 2017

Nanobiotix receives FDA approval for first immuno-oncology trial

NANOBIOTIX, a late clinical-stage nanomedicine company pioneering new approaches to the treatment of cancer, today announced the U.S. Food and Drug Administration has approved its Investigational New Drug Application for NBTXR3, a first-in-class nanoparticle designed for direct injection into cancerous tumors, activated by stereotactic ablative radiotherapy (SABR) and administered in combination with an anti-PD1 antibody (nivolumab or pembrolizumab).

26 Dec 2017

Novartis announces FDA approval of its first and only CML therapy with TFR data in product label

Novartis announced today that the US Food and Drug Administration (FDA) approved the inclusion of Treatment-free Remission (TFR) data in the Tasigna® (nilotinib) US product label.

26 Dec 2017

Study opens up new avenues for stopping calcific aortic valve disease

The diminutive size of our aortic valve -- just shy of a quarter -- belies its essential role in pushing oxygen-rich blood from the heart into the aorta, our body's largest vessel, and from there to all other organs. Yet for decades, researchers have focused less on damaged valves than on atherosclerosis, the gradual hardening of the blood vessels themselves.

26 Dec 2017

International researchers find valuable clues for developing robust therapeutic agents against IBDs

Our immune system protects our bodies from numerous pathogenic microbes and toxins in the environment. The system comprises innate (non-specific) and adaptive (acquired) immunity.

26 Dec 2017

Study identifies biomarker targets to make existing drugs better at combating cancer

A new study published in Nature Communications and led by University of Kentucky Markey Cancer Center researcher Qing-Bai She identifies biomarker targets that may make existing drugs more effective in fighting certain cancers.

22 Dec 2017

FDA chief says he’s open to rethinking incentives on orphan drugs

The commissioner of the Food and Drug Administration questions whether the right financial incentives are in place for drugmakers who develop orphan drugs for rare diseases.

22 Dec 2017

Biosimilars, biologics and new legal challenges for RA treatments

Early last winter, Pfizer launched its new rheumatoid arthritis treatment, Inflectra, pricing it 15 percent below the $4,000-a-dose wholesale price of Remicade, the drug for which it is a close copy.

22 Dec 2017

FDA approves drug to increase blood pressure in adults with septic or distributive shock

The U.S. Food and Drug Administration today approved Giapreza (angiotensin II) injection for intravenous infusion to increase blood pressure in adults with septic or other distributive shock.

21 Dec 2017

Higher ‘mutational burden’ of tumors predicts success rate with cancer immunotherapies

The "mutational burden," or the number of mutations present in a tumor's DNA, is a good predictor of whether that cancer type will respond to a class of cancer immunotherapy drugs known as checkpoint inhibitors, a new study led by Johns Hopkins Kimmel Cancer Center researchers shows.

21 Dec 2017

Ability to defend against environmental stress may affect longevity

A shorter life may be the price an organism pays for coping with the natural assaults of daily living, according to researchers at the National Institutes of Health and their colleagues in Japan.

21 Dec 2017

Multifunctional protein also plays role in development of blood cells

Like an actor who excels at both comedy and drama, proteins also can play multiple roles. Uncovering these varied talents can teach researchers more about the inner workings of cells.

21 Dec 2017

Researchers develop more accurate method to gauge incidence of HIV infections

Researchers at the Duke Human Vaccine Institute have led an effort to develop a more accurate way to gauge the incidence of HIV infections in large populations, which will improve research and prevention strategies worldwide.

21 Dec 2017

Tumor growth traits can influence response to cancer drugs, study finds

Individual tumors respond differently to cancer drugs, if at all. Until now, it remained a mystery why tumors have different reactions to the exact same therapy. But a new study at the USC Viterbi School of Engineering finds that tumor growth properties can influence response to cancer drugs.

21 Dec 2017

Loss of specific protein makes breast cancers more aggressive, resistant to chemotherapy

Researchers in Italy have discovered how specific versions of a protein called Numb protect the key tumor suppressor p53 from destruction.

21 Dec 2017

Drugs alone may not improve chances of successful quitting among smokers, study suggests

Pharmaceutical interventions are routinely prescribed to help people quit smoking. However, a new study by University of California San Diego School of Medicine researchers suggests that, despite promising results in clinical trials, smoking cessation drugs alone may not be improving the chances of successful quitting among smokers in general.

21 Dec 2017

Drugs News and Research

Researchers discover internal body scales that regulate fat mass

Reduced activity of transcription factor plays key role in triggering pulmonary fibrosis

Nanobiotix receives FDA approval for first immuno-oncology trial

Novartis announces FDA approval of its first and only CML therapy with TFR data in product label

Study opens up new avenues for stopping calcific aortic valve disease

International researchers find valuable clues for developing robust therapeutic agents against IBDs

Study identifies biomarker targets to make existing drugs better at combating cancer

FDA chief says he’s open to rethinking incentives on orphan drugs

Biosimilars, biologics and new legal challenges for RA treatments

FDA approves drug to increase blood pressure in adults with septic or distributive shock

Higher ‘mutational burden’ of tumors predicts success rate with cancer immunotherapies

Ability to defend against environmental stress may affect longevity

Multifunctional protein also plays role in development of blood cells

Researchers develop more accurate method to gauge incidence of HIV infections

Tumor growth traits can influence response to cancer drugs, study finds

Loss of specific protein makes breast cancers more aggressive, resistant to chemotherapy

Drugs alone may not improve chances of successful quitting among smokers, study suggests

Psychosocial risks experienced during adolescence may increase chance of HIV in adulthood

High out-of-pocket costs act as barrier to potentially life-saving cancer treatments

UTA researchers analyze challenges in pain management for the elderly

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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