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SARS-CoV-2 entry at the cell surface facilitated by trypsin

Exogenous trypsin treatment boosts SARS-CoV-2 infection in Vero E6 cells and promotes viral multiplication in cultured cells.

1 Feb 2022

Researchers develop a single-use sensor strip to detect cerebrospinal fluid leaks

Developing rapid clinical testing for cerebrospinal fluid (CSF) leaks after trauma, surgery, tumors, and other defects are vital, because such leaks can cause life-threatening conditions, such as meningitis and intercranial infection.

1 Feb 2022

High levels of neutralizing antibodies against Omicron after BNT162b2 booster vaccination

Researchers analyze the neutralizing antibody levels against SARS-CoV-2 VOCs in individuals after receiving their second and third doses.

1 Feb 2022

Mutational analysis of SARS-CoV-2 main protease

A new study discussed the findings of a comprehensive mutational analysis of the main protease (Mpro) of SARS-CoV-2.

1 Feb 2022

Assessing the neutralizing ability of polyclonal antibody XAV-19 against SARS-CoV-2 Omicron variant

In a new study, a team of researchers assessed the neutralizing activity of XAV-19, a glyco-humanized polyclonal antibody derived from hyperimmunized animal hosts, against the SARS-CoV-2 Omicron variant.

1 Feb 2022

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

In a new study, a team of researchers used co-immunoprecipitation and in vitro interaction assays to identify the molecular basis of interaction of SARS-CoV-2 non-structural protein 2 with eIF4E-homologous protein (4EHP)-GRB10-interacting glycine-tyrosine-phenylalanine domain protein 2 complex, involved in microRNA-mediated gene silencing in human cells.

1 Feb 2022

Researchers explore natural SARS-CoV-2 infection in pet rabbits in France

In a new study, researchers reported the first evidence of natural SARS-CoV-2 infections among domestic rabbits in France.

1 Feb 2022

Exploring beta-coronavirus neutralization by vaccine-induced murine antibody WS6

In a new study, researchers evaluated the neutralizing antibody titers in mice vaccinated with messenger ribonucleic acid (mRNA) encoding SARS-CoV-2 spike (S) protein.

1 Feb 2022

Study shows mRNA booster dose eliminates immune escape observed with SARS-CoV-2 Omicron

Researchers examined total and neutralizing antibodies to the spike protein of SARS-CoV-2, and neutralizing antibodies against Washington-1 (WA-1) and variants of concern (VOC) including Beta, Delta, and Omicron in a longitudinal cohort.

31 Jan 2022

Preliminary study assesses durability of NAb titers against Omicron after mRNA-1273 booster

Researchers from Moderna, the developers of one key vaccine, have been investigating its ability to protect against the Omicron variant.

31 Jan 2022

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

A new study by Norwegian researchers suggests that vaccine-induced immunological memory and the activation of recall responses in the body yields similar coverage for Omicron and Delta variants of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The paper is currently available on the medRxiv* preprint server while it undergoes peer review.

31 Jan 2022

Children and adolescents respond as well or better than adults to mRNA-1273 COVID vaccination

A recent study assesses the neutralization efficacy of the mRNA-1273 vaccine against the SARS-CoV-2 Omicron variant in children, adolescents, and adults.

30 Jan 2022

Immunity based upon “mild" Omicron infection is weak for Omicron reinfection

Researchers evaluate antibody responses in vaccinated individuals who subsequently developed Delta and Omicron SARS-CoV-2 breakthrough infections.

30 Jan 2022

Scientists evaluate zoonotic potential of NeoCoV, a coronavirus related to MERS-CoV

Researchers identify ACE2 as the functional receptor of the two close relatives of MERS-CoV, NeoCoV and PDF-2180-CoV, in bats.

30 Jan 2022

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

Researchers demonstrate how cytotoxic T-lymphocytes (CTLs) with specificity for SARS-CoV-2 eliminate multiple infected targets.

30 Jan 2022

Adults and children have similar neutralizing antibody responses to SARS-CoV-2 infection

Researchers describe the kinetics of SARS-CoV-2-specific serum antibodies in convalescent children over six months following infection.

30 Jan 2022

New app and lab kit transform a smartphone into COVID-19 / flu detection system

In a potential game changer for COVID-19 pandemic control efforts, a new cell phone app and lab kit have transformed a smartphone into a COVID-19 / flu detection system.

29 Jan 2022

Evidence on intra-host recombination of SARS-CoV-2 during superinfection by Alpha and Epsilon variants in USA

A new study captured an instance of SARS-CoV-2 superinfection in an individual, simultaneously infected by two SARS-CoV-2 variants, Alpha and Epsilon during the second COVID-19 wave in New York City in early 2021.

28 Jan 2022

Reduced neutralization against Omicron variant in fully immunized adolescents with BNT162b2 vaccine

Researchers compare the humoral immune response in adolescents and adults after being completely immunized with the Pfizer BNT162b2 vaccine.

28 Jan 2022

Impact of DNA clearance on mortality in patients with severe COVID-19 infections

In a new study, researchers conducted activity-based proteomic profiling of patients who had severe SARS-CoV-2 infections to understand the impact of DNA clearance on mortality.

28 Jan 2022

Assay News and Research

SARS-CoV-2 entry at the cell surface facilitated by trypsin

Researchers develop a single-use sensor strip to detect cerebrospinal fluid leaks

High levels of neutralizing antibodies against Omicron after BNT162b2 booster vaccination

Mutational analysis of SARS-CoV-2 main protease

Assessing the neutralizing ability of polyclonal antibody XAV-19 against SARS-CoV-2 Omicron variant

SARS-CoV-2 protein NSP2 found to impair microRNA-induced gene silencing in human cells

Researchers explore natural SARS-CoV-2 infection in pet rabbits in France

Exploring beta-coronavirus neutralization by vaccine-induced murine antibody WS6

Study shows mRNA booster dose eliminates immune escape observed with SARS-CoV-2 Omicron

Preliminary study assesses durability of NAb titers against Omicron after mRNA-1273 booster

Vaccine-induced immunological memory is similar for Omicron and Delta SARS-CoV-2 variants

Children and adolescents respond as well or better than adults to mRNA-1273 COVID vaccination

Immunity based upon “mild" Omicron infection is weak for Omicron reinfection

Scientists evaluate zoonotic potential of NeoCoV, a coronavirus related to MERS-CoV

Imaging microscopy shows killer T-cells targeting SARS-CoV-2 spike protein

Adults and children have similar neutralizing antibody responses to SARS-CoV-2 infection

New app and lab kit transform a smartphone into COVID-19 / flu detection system

Evidence on intra-host recombination of SARS-CoV-2 during superinfection by Alpha and Epsilon variants in USA

Reduced neutralization against Omicron variant in fully immunized adolescents with BNT162b2 vaccine

Impact of DNA clearance on mortality in patients with severe COVID-19 infections

eBook: Using iPSCs models for human disease research and drug discovery eBook

How Omics Technologies Are Transforming Biological Research and Drug Discovery

How microplastics and bacteria interact to drive antibiotic resistance

Single-cell proteomics: Revealing proteome diversity from cellular heterogeneity to non-canonical biology

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