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Two studies spotlight intestinal T cells that could be targeted to prevent resistance to ICB cancer therapy

Two new studies in Science and Science Immunology spotlight a group of intestinal T cells with α4β7 integrin receptors that could be targeted to prevent resistance to immune checkpoint blockade (ICB) cancer immunotherapy.

8 Jun 2023

Global study provides high-quality data to improve treatment of newborn babies with sepsis

A global observational study, which involved more than 3,200 newborn babies suffering from sepsis in 19 hospitals in 11 countries, has shown that many newborns are dying because the antibiotics used to treat sepsis are losing their effectiveness.

8 Jun 2023

Newly discovered bacterial species can have a major role in causing tooth decay

Collaborating researchers from the University of Pennsylvania School of Dental Medicine and the Adams School of Dentistry and Gillings School of Global Public Health at the University of North Carolina have discovered that a bacterial species called Selenomonas sputigena can have a major role in causing tooth decay.

8 Jun 2023

Study examines the combined toxicity of common environmental pollutants on the gut-brain axis

Regulating environmental pollution around the world still largely relies upon risk assessments of "single pollutants," ignoring combined toxicities and interactions of groups of substances.

8 Jun 2023

Study identifies a promising target for development of vaccine against spotted fever

A protein found in cells of the hard tick Amblyomma sculptum, the main vector of the bacterium that causes Brazilian spotted fever (also known as Rocky Mountain spotted fever), is essential to the tick's survival while feeding, making it a promising target for development of a vaccine, according to an article published in the journal Parasites & Vectors.

7 Jun 2023

How do antibiotics affect the ecology of the gut microbiome?

Each person's gut microbiome contains a specific community of microorganisms that normally remains stable for years. However, it can be thrown off balance by factors such as dietary changes, infections or medications. Antibiotics in particular have a strong influence on the microbiome. In response, microorganisms employ various resistance mechanisms, with individual bacterial populations evolving through selection of antibiotic-resistant variants. Yet, the extent and mechanisms of these processes and their impact on the ecology of the microbial community are poorly understood.

7 Jun 2023

Vaginal microbial diversity and pregnancy outcomes

Researchers examined the diversity, community-type prevalence, and role of the vaginal microbiota in various pregnancy outcomes.

6 Jun 2023

International response may be inadequate to meet the scale and severity of antimicrobial resistance

Governments around the world must do more to tackle the growing threat of drug-resistant infections, new research suggests.

5 Jun 2023

New antibiotic-resistance genes are present in bacteria in almost all environments, study shows

Genes that make bacteria resistant to antibiotics are much more widespread in our environment than was previously realised.

5 Jun 2023

An overview of the French antibiotic resistance surveillance system in the human, animal, and environmental sectors

Researchers evaluated French surveillance for antibiotic resistance (ABR), usage, and residues.

5 Jun 2023

Cutting free flu jabs for 50-64-year-olds and mpox vaccines could lead to future strains on the NHS, says expert

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5 Jun 2023

Cross-country culinary microbes: Uncovering a shared kitchen microbiota across European homes

Microbial diversity in residential kitchens across five European countries was examined, revealing common bacterial genera/families and their distribution on cleaning utensils and kitchen surfaces. The study highlights variations in microbial composition by country, object type, and cleaning utensil material.

4 Jun 2023

University of Louisville researchers receive $5.8 million to prevent immune system dysregulation

Researchers at the University of Louisville have received $5.8 million in two grants from the National Institutes of Health to expand their work to better understand and prevent immune system dysregulation responsible for acute respiratory distress, the condition responsible for serious illness and death in some COVID-19 patients.

2 Jun 2023

How does a riboswitch regulate its own synthesis?

To prevent a global health crisis, scientists around the world are searching for ways to fight bacteria that can evade the current arsenal of antibiotics.

2 Jun 2023

"Sepsis sensors" with magnetic nanoparticles rapidly detect bacterial pathogens

In the case of blood poisoning, the bacteria in the blood must be identified as fast as possible so that a life-saving therapy can be started.

1 Jun 2023

Smoke alarm: France's high maternal smoking rates fuel prematurity and low birth weight

Research highlights the adverse effects of active and passive maternal smoking on low birth weight and preterm delivery rates. It emphasizes the importance of smoking cessation and tobacco control policies to improve maternal and child health outcomes.

1 Jun 2023

St. Jude researchers discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Infections and other diseases can cause red blood cells to rupture, releasing the oxygen-binding molecule hemoglobin, which breaks down into heme.

1 Jun 2023

Peptidomimetic antibiotics may be effective against resistant bacteria

Health professionals are in urgent need of new antibiotics to tackle resistant bacteria. Researchers at the University of Zurich and the company Spexis have now modified the chemical structure of naturally occurring peptides to develop antimicrobial molecules that bind to novel targets in the bacteria's metabolism.

1 Jun 2023

Real-world management and outcomes of U.S. patients treated with BpaL for rifampin-resistant tuberculosis

Researchers reported on the treatment of rifampin-resistant tuberculosis in the United States using the FDA approved bedaquiline, pretomanid, and linezolid (BPaL) therapy.

1 Jun 2023

Unique combination of intestinal bacteria in Japanese centenarians may be the key to long life

We are pursuing the dream of eternal life. We fast to stay healthy. And each year, we spend billions of kroner on treatment to make sure we stay alive. But some people turn 100 years old all by themselves. Why is that?

31 May 2023

Bacterial News and Research

Two studies spotlight intestinal T cells that could be targeted to prevent resistance to ICB cancer therapy

Global study provides high-quality data to improve treatment of newborn babies with sepsis

Newly discovered bacterial species can have a major role in causing tooth decay

Study examines the combined toxicity of common environmental pollutants on the gut-brain axis

Study identifies a promising target for development of vaccine against spotted fever

How do antibiotics affect the ecology of the gut microbiome?

Vaginal microbial diversity and pregnancy outcomes

International response may be inadequate to meet the scale and severity of antimicrobial resistance

New antibiotic-resistance genes are present in bacteria in almost all environments, study shows

An overview of the French antibiotic resistance surveillance system in the human, animal, and environmental sectors

Cutting free flu jabs for 50-64-year-olds and mpox vaccines could lead to future strains on the NHS, says expert

Cross-country culinary microbes: Uncovering a shared kitchen microbiota across European homes

University of Louisville researchers receive $5.8 million to prevent immune system dysregulation

How does a riboswitch regulate its own synthesis?

"Sepsis sensors" with magnetic nanoparticles rapidly detect bacterial pathogens

Smoke alarm: France's high maternal smoking rates fuel prematurity and low birth weight

St. Jude researchers discover NLRP12 as a direct bridge from hemolysis to inflammatory disease

Peptidomimetic antibiotics may be effective against resistant bacteria

Real-world management and outcomes of U.S. patients treated with BpaL for rifampin-resistant tuberculosis

Unique combination of intestinal bacteria in Japanese centenarians may be the key to long life

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