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Specific immune signature identified in COVID-19 patients

Researchers at King’s College London and collaborators have identified an “immune signature” that could help researchers better understand coronavirus disease 2019 (COVID-19) and serve as a valuable resource for predicting patient prognosis and informing clinical risk-based stratification.

10 Jun 2020

3D printing technology can inhibit the proliferation of cancer cells in vitro

Doctors could soon be administering an entire course of treatment for life-threatening conditions with a 3D printed capsule controlled by magnetic fields thanks to advances made by the University of Sussex researchers.

10 Jun 2020

Innovative algorithm helps select patients in need of urgent surgery or chemotherapy during COVID-19

A new approach to better select breast cancer patients in need of urgent surgery or chemotherapy during the COVID-19 pandemic has been developed by researchers at The Royal Marsden and the Breast Cancer Now Research Centre at The Institute of Cancer Research, London, in collaboration with colleagues in the UK, Germany and US.

8 Jun 2020

Researchers confirm new therapeutic target for myelodysplastic syndrome

A research group from Kumamoto University, Japan analyzed the pathophysiology of myelodysplastic syndrome (MDS), a blood cancer that presents often in the elderly, and found the presence of the transcription factor RUNX3, thereby revealing a cancer growth function for what had been considered a tumor suppressor.

8 Jun 2020

Malaria risk in deforestation hotspots linked to demand for agricultural commodities

A paper recently published in Nature Communications is the first to show a connection between demand from certain developed countries for agricultural commodities and the growing risk of malaria in the countries that supply those goods.

4 Jun 2020

Tumors cause disruption of the immune system throughout the body, study finds

Cancer treatment has advanced with the advent of immunotherapies that, in some cancers, can overcome tumors' ability to evade the immune system by suppressing local immune responses.

3 Jun 2020

Mini tumors predict how cancer responds to heat treatment

Hyperthermia has shown promise in the treatment of cancer in previous studies. Now, in a new study by scientists at The Institute of Cancer Research, London, the researchers tested the effects of a combination of heat and radiation on mini tumors grown in a spheroid, where cells are placed in a three-dimensional structure. The research is published in the journal Scientific Reports.

3 Jun 2020

Optimal measures to reduce the chance of viral infection

Keeping at least one metre from other people as well as wearing face coverings and eye protection, in and outside of health-care settings, could be the best way to reduce the chance of viral infection or transmission of COVID-19.

2 Jun 2020

Specific immune suppression leads to severe COVID-19 disease

A new study published online on the preprint server medRxiv in May 2020 reports that specific changes in the way the human immune system responds to COVID-19 determine whether the individual develops moderate or severe illness.

2 Jun 2020

How comorbidities affect SARS-CoV-2 viral entry

Almost from the start of the current COVID-19 pandemic, it has become clear that individuals suffering from other medical conditions like diabetes, cardiovascular disease, and lung disease are far more likely to contract the infection and to have a poorer outcome.

28 May 2020

Ferritin heavy chain protein shows promise as a potential SARS-CoV-2 vaccine or antiviral

A new study published on the online preprint server bioRxiv in May 2020 reports the construction and testing of a new ferritin-based antigen-bearing protein that has biological activity towards the ACE2 receptor. This could indicate its potential for development as a vaccine or antiviral.

28 May 2020

Scientists create adenovirus that kills cancer cells

An adenovirus is now better able to target and kill cancer cells due to the addition of an RNA stabilizing element.

28 May 2020

ACE2 receptors in the kidney not linked to high BP or RAS blockers

Even as the COVID-19 pandemic continues to smolder and flare up in various parts of the world, researchers are still trying to make sense of the virus, its routes of spread, its target tissues, and the immune responses it induces. One crucial piece of knowledge is that the primary viral receptor is a human enzyme called angiotensin-converting enzyme 2 (ACE2).

27 May 2020

No-deductible preventive drugs can reduce out-of-pocket costs for diabetic patients

For patients with diabetes - especially those with lower incomes - preventive drug lists (PDLs) of essential medications available with no deductible can reduce out-of-pocket costs while increasing use of important treatments, reports a study in a June supplement to Medical Care.

27 May 2020

Capillary leakage important in COVID-19 respiratory distress

Now, a new study published on the preprint server medRxiv reports the pivotal role played by protein leakage through lung capillaries and promotes the use of serum albumin as a biomarker of disease progression and severity.

24 May 2020

Scientists create a detailed map of how carcinogens trigger breast cancer development

In the most comprehensive review to date of how breast cancer develops, scientists have created a detailed map that describes the many ways in which environmental chemicals can trigger the disease.

21 May 2020

Scientists use new model to develop cancer stem cells

Liver cancer is one of the deadliest cancers. It is insidious and does not present symptoms until it has progressed considerably, at which point, treatment options are limited and chances of survival are low. The most common type of liver cancer is hepatocellular carcinoma (HCC).

21 May 2020

Study could help identify more targeted treatments for ovarian cancer

The rogue cellular engine that drives a majority of ovarian cancers remains frustratingly difficult to disable. A new study comparing cancerous tissue with normal fallopian tube samples advances important insights about this machinery and confirms biological hallmarks of survival.

20 May 2020

Study shows how cancer protein changes may accelerate tumorigenesis and metastasis

Understanding the genetic mutations and protein changes that take place in the progression of cancer is key to its treatment. Mutations in the gene TP53 and concomitant mutant p53 proteins in cancer cells have become notorious over the course of multiple studies of several different types of cancers.

18 May 2020