Bile News and Research

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New grant aims to transform treatment for liver cancer

Currently, there are a few available treatment options for liver cancer, including a combination of immunotherapies and a class of drugs known as tyrosine kinase inhibitors (TKIs), but their long-term effects are limited.

17 Oct 2024

Chronic stress disrupts gut microbiota, promoting colorectal cancer growth

Cutting-edge research has uncovered how chronic stress disrupts the balance of gut microbiota to speed up the progression of colorectal cancer (CRC), opening new avenues for CRC prevention and treatment.

13 Oct 2024

How gut microbiome and fiber diversity shape chronic disease outcomes

Review explores how different types of dietary fibers interact with the gut microbiome, influencing chronic disease risks like obesity, cancer, and cardiometabolic conditions, while emphasizing the need for personalized dietary interventions.

13 Oct 2024

Researchers uncover key bacteria driving success of fecal microbiota transplants

Fecal microbiota transplants, or FMTs, are a magic bullet for patients with recurring infections from Clostridioides difficile (C. diff), but researchers are only beginning to understand why.

9 Oct 2024

New pipeline of drug candidates offers hope for effective MASLD treatments

Non-alcoholic fatty liver disease (NAFLD), recently reclassified as metabolic dysfunction-associated steatotic liver disease (MASLD), has become the most prevalent chronic liver disease globally.

25 Sep 2024

How plant-based, Mediterranean, and Western diets affect gut microbiota and disease

Researchers examine how different dietary components affect the gut microbiome and development of non-communicable diseases.

20 Sep 2024

Review highlights mitochondrial dysfunction in cholestatic liver injury

Bile acids are essential signaling molecules derived from cholesterol metabolism in the liver and are crucial for the digestion and absorption of fats.

16 Sep 2024

Real-world evidence highlights safety profile of tirzepatide in managing type 2 diabetes

As more people with type 2 diabetes (T2D) are taking medications to help manage blood sugar levels and weight loss, concerns about whether these drugs are safe have emerged.

12 Sep 2024

Lipidomics and metabolomics as potential biomarkers for breast cancer progression

This review highlights the potential of lipidomic and metabolomic biomarkers in predicting breast cancer prognosis and therapy response, enhancing patient care.

5 Sep 2024

Researchers demonstrate a new method to combat pancreatic cancer

Researchers at the University of Massachusetts Amherst and UMass Chan Medical School have demonstrated in mice a new method to combat pancreatic cancer.

28 Aug 2024

How diet shapes gut microbiota and affects brain function

Researchers discuss the diet-microbiota-gut-brain axis, which describes the role of both diet and gut microbiota composition on cognitive and emotional health.

26 Aug 2024

SCARB2 deficiency disrupts bile acid metabolism and gut microbiome

The study details the connection between SCARB2 deficiency and gastrointestinal dysfunction, revealing that the loss of SCARB2 leads to alterations in bile acid metabolism and dysbiosis in the gut microbiome. This disruption affects the signaling pathway involving FXR, which normally regulates bile acid synthesis and intestinal lipid absorption. The hyperactive FXR in Scarb2-deficient mice leads to a decrease in epithelial cell turnover and lipid malabsorption, particularly impacting the absorption of vitamin E, which is crucial for maintaining neurological health. The researchers further explored the impact of these changes on the gut-liver axis and found alterations in the expression of genes related to bile acid synthesis.

23 Aug 2024

Questioning the effectiveness of cholecystectomy for functional gallbladder disorder

Although surgery is a common treatment for patients diagnosed with biliary dyskinesia, or functional gallbladder disorder, a West Virginia University medical researcher is questioning why the practice has become so widespread when little clinical research is available.

20 Aug 2024

How persistent organic pollutants affect gut health: findings on metabolic disruptions and microbiota changes

Early life exposure to potent AHR agonists on gut microbiota and its potential effects on metabolic health later in life.

20 Aug 2024

Gut microbiota plays a crucial role in type 2 diabetes management

Research reveals the intricate role of gut microbiota in type 2 diabetes, highlighting personalized therapeutic strategies and the complexity of microbial interactions with antidiabetic drugs.

15 Aug 2024

Study finds minimal impact of cesarean antibiotics on infant gut microbiome

Cesarean section recipients are usually given prophylactic antibiotics just before the procedure to prevent later infections at the surgical site.

14 Aug 2024

Renowned surgical oncologist takes leadership role at NYU Grossman Long Island School of Medicine

The Perlmutter Cancer Center at NYU Langone Hospital—Long Island has appointed Gary B. Deutsch, MD, MPH, a renowned and innovative surgical oncologist, as chief of NYU Grossman Long Island School of Medicine's Division of Surgical Oncology.

5 Aug 2024

Researchers receive $9.5M to study polyphenols' impact on cognitive health

UCLA Health researchers, in collaboration with researchers from the Republic of Ireland and Northern Ireland, have received $9.5 million award from the National Institutes of Health (NIH) with support from European funding agencies - The Science Foundation Ireland (SFI) and the Public Health Agency Health & Social Care (HSC) - to study the effects of polyphenols on cognitive health and the brain-gut microbiome system.

5 Aug 2024

Honey enhances probiotic survival in yogurt

If you enjoy a bowl of plain yogurt in the morning, adding a spoonful of honey is a delicious way to sweeten your favorite breakfast food.

5 Aug 2024

Rising cancer rates in younger generations signal urgent need for early-life prevention strategies

A study in The Lancet Public Health reveals rising cancer incidence and mortality among younger US birth cohorts, indicating increased early-life carcinogenic exposure.

4 Aug 2024

Bile News and Research

New grant aims to transform treatment for liver cancer

Chronic stress disrupts gut microbiota, promoting colorectal cancer growth

How gut microbiome and fiber diversity shape chronic disease outcomes

Researchers uncover key bacteria driving success of fecal microbiota transplants

New pipeline of drug candidates offers hope for effective MASLD treatments

How plant-based, Mediterranean, and Western diets affect gut microbiota and disease

Review highlights mitochondrial dysfunction in cholestatic liver injury

Real-world evidence highlights safety profile of tirzepatide in managing type 2 diabetes

Lipidomics and metabolomics as potential biomarkers for breast cancer progression

Researchers demonstrate a new method to combat pancreatic cancer

How diet shapes gut microbiota and affects brain function

SCARB2 deficiency disrupts bile acid metabolism and gut microbiome

Questioning the effectiveness of cholecystectomy for functional gallbladder disorder

How persistent organic pollutants affect gut health: findings on metabolic disruptions and microbiota changes

Gut microbiota plays a crucial role in type 2 diabetes management

Study finds minimal impact of cesarean antibiotics on infant gut microbiome

Renowned surgical oncologist takes leadership role at NYU Grossman Long Island School of Medicine

Researchers receive $9.5M to study polyphenols' impact on cognitive health

Honey enhances probiotic survival in yogurt

Rising cancer rates in younger generations signal urgent need for early-life prevention strategies

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