Cancer Immunotherapy News and Research

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Tim-3 identified as promising therapeutic target for Alzheimer's disease

Tim-3 is an immune checkpoint molecule involved in immunity and inflammation recently linked to late-onset Alzheimer's disease (AD), but its role in the brain was unknown until now.

9 Apr 2025

Blocking an enzyme to overcome immunotherapy resistance in melanoma patients

About 65% of melanoma patients do not respond to immunotherapy. New work by the team of Prof. Max Mazzone (VIB-KU Leuven Center for Cancer Biology) discovered that an enzyme called HPGDS (expressed in a specific subset of macrophages), plays a key role in immunotherapy resistance.

7 Apr 2025

EchoBack CAR T-cells could be a game changer in cancer immunotherapy

Imagine a super-charged immune cell that can launch a focused attack on stubborn solid tumors - a smart fighter that destroys cancer cells for days without tiring.

2 Apr 2025

ICRAFT platform identifies new targets for cancer immunotherapy

Professor Zeng Zexian's team from the Center for Quantitative Biology at the Peking University Academy for Advanced Interdisciplinary Studies, in collaboration with the Peking University-Tsinghua University Joint Center for Life Sciences, has developed ICRAFT, an innovative computational platform for identifying cancer immunotherapy targets.

1 Apr 2025

New TIL therapy improves treatment's effectiveness in patients with metastatic gastrointestinal cancers

A new form of tumor infiltrating lymphocyte (TIL) therapy, a form of personalized cancer immunotherapy, dramatically improved the treatment's effectiveness in patients with metastatic gastrointestinal cancers, according to results of a clinical trial led by researchers at the National Institutes of Health (NIH).

1 Apr 2025

Researchers develop TIM-3 decoy to enhance CAR-T therapy effectiveness for B-ALL tumors

B-cell Acute Lymphoblastic Leukemia (B-ALL) is a life-threatening and highly aggressive form of blood cancer. It is the most common childhood cancer, making up 35% of pediatric cancer cases, but it can affect people of any age.

24 Mar 2025

Researchers develop tool to enhance NK cells against cancer

A team of researchers from the Hospital del Mar Research Institute, the Universitat Autònoma de Barcelona and the Pompeu Fabra University has developed a new tool that allows modifying these NK cells to make them immune to the tumor’s defense mechanism.

24 Mar 2025

WIN Consortium revolutionizing precision oncology for cancer patients

A new precision oncology paper was published in Oncotarget, Volume 16, on March 12, 2025, titled "Worldwide Innovative Network (WIN) Consortium in Personalized Cancer Medicine: Bringing next-generation precision oncology to patients."

18 Mar 2025

New insights into ADAR1 mechanisms could revolutionize autoimmune and cancer therapies

A research team led by Rice University's Yang Gao has uncovered new insights into the molecular mechanisms of ADAR1, a protein that regulates ribonucleic acid (RNA) induced immune responses.

17 Mar 2025

Targeting MARCO enhances cancer immunotherapy effectiveness

Researchers from Moffitt Cancer Center have found a new way to boost cancer immunotherapy by targeting a protein called macrophage receptor with collagenous structure, or MARCO.

13 Mar 2025

Combination immunotherapy improves treatment response for head and neck cancer

Researchers conducting a clinical trial of immunotherapy drugs for people with head and neck squamous cell carcinomas (HNSCCs) found that patients responded better to a combination of two immunotherapies than patients who received just one immunotherapy drug.

13 Mar 2025

New test could predict life-threatening side effects of cancer immunotherapy

Medical researchers in Japan have discovered a way to predict a potentially life-threatening side effect of cancer immunotherapy before it occurs.

10 Mar 2025

New supercharged CAR-T cell therapy shows promise against resistant cancers

Researchers at the University of Colorado Anschutz Medical Campus have successfully developed a supercharged iteration of CAR-T cell therapy that can enhance the effectiveness and longevity of the cells, particularly against cancer cells that are harder for prior CAR-T therapies to detect and fight.

10 Mar 2025

Researchers uncover how brain tumors reprogram neutrophils to hinder cancer treatment

The lab of Filippo Veglia, Ph.D., at The Wistar Institute has discovered a previously unknown mechanism for how aggressive brain cancers reprogram immune system cells from fighting cancer to enabling further tumor growth.

2 Mar 2025

LMU study uncovers dual functionality of dendritic cells in immune response

LMU researchers have shown that a particular type of immune cell acts more flexibly than previously thought - with potential for new therapeutic approaches.

26 Feb 2025

New antibody-toxin conjugate designed to stimulate immune-mediated eradication of tumors

Researchers at The University of Texas MD Anderson Cancer Center have developed a novel antibody-toxin conjugate (ATC) designed to stimulate immune-mediated eradication of tumors.

25 Feb 2025

Study unravels the complex interplay of the UPS in cancer development and treatment

A new review published in Genes & Diseases explores the pivotal role of the ubiquitin-proteasome system (UPS) in regulating the tumor microenvironment (TME) and driving cancer progression. The study provides novel insights into how ubiquitination and deubiquitination impact tumor cells, immune responses, and potential therapeutic strategies for cancer treatment.

24 Feb 2025

Gut microbes influence how well cancer patients respond to immunotherapy

Researchers discovered that gut microbiota-derived hexa-acylated LPS enhances the effectiveness of anti-PD-1 cancer immunotherapy, while penta-acylated LPS may suppress immune responses.

11 Feb 2025

New mechanism of immune evasion discovered in cancer cells

The immune system plays a key role in detecting and destroying cancer cells. Cancer immunotherapy works by programming immune cells to recognize and eliminate cancer cells.

11 Feb 2025

Modifying biomaterials may lead to more effective cancer therapies

Modifying the physical characteristics of microscopic biomaterials to interact seamlessly with the body's tissues could unlock safer and more effective cancer treatments, according to Virginia Tech researchers at the Fralin Biomedical Research Institute at VTC.

7 Feb 2025