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Evaluating the efficacy of harmol in treating herpes simplex virus-induced keratitis

The antiviral efficacy and therapeutic potential of harmol in treating herpes simplex virus type 1 (HSV-1) induced keratitis

29 May 2024

Study finds Plexin-B1 could be key to Alzheimer’s treatment, enhancing glial cell response

Researchers discovered that Plexin-B1 plays a crucial role in regulating peri-plaque glial nets in Alzheimer’s disease, potentially opening new avenues for treatment by targeting this protein.

29 May 2024

Metabolic cell death pathways could be novel therapeutic targets in cancer treatment

The review discusses how metabolic cell death, distinct from traditional forms of regulated cell death like apoptosis, arises from imbalances in cellular metabolism due to nutrient and metal overload or depletion.

28 May 2024

Targeting CD47 to improve osimertinib efficacy in EGFR mutant NSCLC

NSCLC is the leading cause of cancer deaths globally, with EGFR mutations being a common feature in these cancers.

28 May 2024

Tattoos linked to higher risk of malignant lymphoma, study finds

A recent study in eClinicalMedicine links tattoo ink exposure to a 21% higher risk of malignant lymphoma, particularly B-cell subtypes. Tattoo ink and laser removal may play significant roles in lymphoma development.

28 May 2024

Scientists design new way to "cloak" proteins for targeted therapeutic delivery

Cornell University scientists have designed a way to "cloak" proteins in a generalized technique that could lead to repurposing things like antibodies for biological research and therapeutic applications.

28 May 2024

MUSC researchers unravel the mystery of cancer recurrence

MUSC Hollings Cancer Center researchers have unlocked a discovery that could help to explain why cancer can recur in patients who have undergone chemotherapy or radiotherapy.

28 May 2024

Light therapy may affect healing in the brains of people who suffered traumatic brain injury

Low-level light therapy appears to affect healing in the brains of people who suffered significant brain injuries, according to a study published today in Radiology, a journal of the Radiological Society of North America.

28 May 2024

Underappreciated set of enzymes connected to the regulation of hippo pathway in cancer

Within the family of cell membrane lipids known as phosphoinositides and the kinase enzymes that regulate them, phosphoinositide 3-kinases (PI3Ks) have been cast in a starring role as scientists study their involvement in cancer, diabetes and many cellular activities.

28 May 2024

Research reveals loneliness as a complex interplay of social impairments, oxytocin, and illness

A recent review in the journal Neuroscience & Biobehavioral Reviews presents a multidimensional model of loneliness, exploring its impact on social interactions, the oxytocin system, and illness. The study emphasizes the need for multidisciplinary collaboration to understand and address loneliness effectively.

28 May 2024

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

A new paper in Trends in Pharmacological Sciences from researchers at generative artificial intelligence (AI)- and robotics-powered clinical stage drug discovery company Insilico Medicine ("Insilico") and ETH Zurich reveals the broad potential of TNIK as a therapeutic target for some of the most pervasive aging-related diseases, including fibrosis, cancer, obesity, and Alzheimer's.

28 May 2024

Understanding the link between EBV-infected B cells and multiple sclerosis

The Wistar Institute's Paul M. Lieberman, Ph.D., and lab team led by senior staff scientist and first author, Samantha Soldan, Ph.D., have demonstrated how B cells infected with the Epstein-Barr virus (EBV) can contribute to a pathogenic, inflammatory phenotype that contributes to multiple sclerosis (MS); the group has also shown how these problematic B cells can be selectively targeted in a way that reduces the damaging autoimmune response of multiple sclerosis.

28 May 2024

Study reveals pivotal role of the circadian clock in enhancing checkpoint inhibitor cancer therapy

A multidisciplinary research team at the University of California, Irvine has revealed that the circadian clock – the biological pacemaker that governs daily rhythms in physiological processes, including immune functions – can be leveraged to enhance the efficacy of checkpoint inhibitor cancer therapy.

28 May 2024

Understanding genetic mosaicism in human cells

In a study led by Jan Korbel at the European Molecular Biology Laboratory (EMBL) and Ashley Sanders at the Berlin Institute for Medical Systems Biology of the Max Delbrück Center (MDC-BIMSB), researchers have found that approximately one in 40 human bone marrow cells carry massive chromosomal alterations – copy number variations and chromosomal rearrangements, for example – without causing any apparent disease or abnormality.

28 May 2024

New subset of T cells may enhance cancer immunotherapy

A team of cancer researchers, led by the University of Houston, has discovered a new subset of T cells that may improve the outcome for patients treated with T-cell therapies.

28 May 2024

Researchers discover how protein XPD detects and repairs DNA damage

Researchers at the University of Würzburg, led by Caroline Kisker in cooperation with Claudia Höbartner, discovered how the protein XPD detects a severe DNA damage and controls its repair.

28 May 2024

Researchers develop mathematical model to predict effective dosage range of cancer treatment

Cancer poses significant challenges due to the development of resistance and the likelihood of relapse. Resistance may arise from permanent genetic changes in cancer cells or non-genetic alterations in cancer cell behavior induced by treatment.

28 May 2024

People with disabilities more likely to experience pregnancy complications, report shows

People with disabilities account for 13% of all pregnancies in Ontario, but a new report shows that this population was more likely to experience pregnancy complications such as emergency department visits, hospitalizations, and preterm birth.

28 May 2024

Changing the landscape of R&D to build clinical success from the ground up

In this interview, NewsMedical talks to Amanda Jones at Revvity about the strategies and solutions available to revolutionize the landscape of R&D in clinical research.

From Revvity 28 May 2024

Heart failure triggers multimorbidity by altering stem cells, study reveals

Researchers identified that heart failure (HF) promotes multimorbidity by altering hematopoietic stem cells (HSCs) to produce pro-inflammatory macrophages, increasing vulnerability in multiple organs. The study highlights the role of suppressed TGF-β signaling in these alterations, contributing to chronic inflammation and subsequent health issues.

28 May 2024

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Cell News and Research

Evaluating the efficacy of harmol in treating herpes simplex virus-induced keratitis

Study finds Plexin-B1 could be key to Alzheimer’s treatment, enhancing glial cell response

Metabolic cell death pathways could be novel therapeutic targets in cancer treatment

Targeting CD47 to improve osimertinib efficacy in EGFR mutant NSCLC

Tattoos linked to higher risk of malignant lymphoma, study finds

Scientists design new way to "cloak" proteins for targeted therapeutic delivery

MUSC researchers unravel the mystery of cancer recurrence

Light therapy may affect healing in the brains of people who suffered traumatic brain injury

Underappreciated set of enzymes connected to the regulation of hippo pathway in cancer

Research reveals loneliness as a complex interplay of social impairments, oxytocin, and illness

New paper reveals the broad potential of TNIK as a therapeutic target for some aging-related diseases

Understanding the link between EBV-infected B cells and multiple sclerosis

Study reveals pivotal role of the circadian clock in enhancing checkpoint inhibitor cancer therapy

Understanding genetic mosaicism in human cells

New subset of T cells may enhance cancer immunotherapy

Researchers discover how protein XPD detects and repairs DNA damage

Researchers develop mathematical model to predict effective dosage range of cancer treatment

People with disabilities more likely to experience pregnancy complications, report shows

Changing the landscape of R&D to build clinical success from the ground up

Heart failure triggers multimorbidity by altering stem cells, study reveals

Revolutionizing Life Science: An Interview with SCIEX on ASMS, the SCIEX 7500+ System, and AI-Driven Quantitation

From Discovery Biology to ELRIG Chair

Breathing New Life into Diagnostics: Plasmion's SICRIT Technology

Latest Life Science News