Cocaine Addiction News and Research

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Cocaine dependence (or addiction) is physical and psychological dependency on the regular use of cocaine. It can result in severe physiological damage, psychosis, schizophrenia, lethargy, depression, or a potentially fatal overdose.

Cocaine vaccine to cure addiction undergoes clinical trials

Clinical trials on a cocaine vaccine are currently being conducted by researchers at Baylor College of Medicine in Houston, Texas.

2 Jan 2008

Genetic markers for mental illness

Researchers have discovered natural genetic differences that might help predict the most effective antipsychotic drugs for particular patients with mental disorders such as schizophrenia, Parkinson's and drug addiction.

4 Dec 2007

University of Illinois at Chicago receives $2.2 million grant to develop drugs to suppress cocaine cravings

The University of Illinois at Chicago College of Pharmacy has received a $2.2 million federal grant to develop therapeutics to suppress the cravings of cocaine addicts.

19 Nov 2007

D-cycloserine could help treat drug addiction

Scientists at the U.S. Department of Energy's Brookhaven National Laboratory provide further evidence that a drug known as D-cycloserine could play a role in helping to extinguish the craving behaviors associated with drug addiction.

6 Nov 2007

Antibiotic that appears to control phobias may also be useful in treating addiction

6 Nov 2007

FDA warns about 'stay awake drug' Provigil

The U.S. Food and Drug Administration (FDA) has issued a warning in connection with the drug Provigil because of dangerous side effects.

28 Oct 2007

Stealth learning fosters science education

Rochelle Schwartz-Bloom, a Duke University pharmacology professor who left the lab bench to focus on science education, has developed a tactic for keeping students hands in the air at the end of class.

27 Sep 2007

Catalyst Pharmaceutical Partners starts U.S. phase II trial of CPP-109 in patients with cocaine dependence

Catalyst Pharmaceutical Partners, Inc. a specialty pharmaceutical company that acquires or in-licenses, develops and commercializes prescription drugs for the treatment of drug addiction, today announced that it has initiated its randomized, double-blind, placebo-controlled U.S. Phase II clinical trial of CPP-109 in patients with cocaine dependence.

11 Jul 2007

Cocaine addicts have an altered perception of reward

People addicted to cocaine have an impaired ability to perceive rewards and exercise control due to disruptions in the brain's reward and control circuits, according to a series of brain-mapping studies and neuropsychological tests conducted at the U.S. Department of Energy's Brookhaven National Laboratory.

16 Oct 2006

Brain chemistry finding suggests new target for addiction treatments

Ask anyone who has been addicted to drugs and they'll tell you that the mere sight of someone using their drug of choice - or even people, places, or objects associated with drug use - can trigger an intense desire for the drug.

14 Jun 2006

Psychiatric patients who smoke

An editorial in the January 2006 issue of the Psychiatric Bulletin reviews the evidence for the effectiveness of gene-based smoking cessation packages, and asks whether they are appropriate for psychiatric patients.

10 Jan 2006

Possible new directions for treatments for addiction to cocaine

Cocaine causes specific alterations in the brain's circuitry at a genetic level, including short-term changes that result in a high from the cocaine, as well as long-term changes seen in addiction, researchers from UT Southwestern Medical Center have found.

23 Oct 2005

Research reveals possible mechanisms for the treatment of cocaine addiction

Researchers are now understanding in greater detail the molecular machinery underlying the short-term brain changes that produce the high of cocaine, as well as the longer-term changes behind addiction. Their findings offer hope for targeted drugs that can short-circuit that addiction machinery.

19 Oct 2005

Modafinil may be a possible medicinal treatment for cocaine dependence

Cocaine dependence is a major public health problem affecting thousands of people around the globe. Despite years of active research there are still no approved medications for the treatment of this life-shattering addiction.

10 Jan 2005

Cocaine addicts experience a decrease in D2 receptors affecting brain regions involved with movement, as well as motivation

A new study builds on previous research showing that cocaine-addicted people have a low expression of specific dopamine receptors—D2 receptors—in a portion of the brain called the striatum.

6 Oct 2004

Treating cocaine addiction with a virus

Scientists at The Scripps Research Institute have designed a potentially valuable tool for treating cocaine addiction by creating a modified "phage" virus that soaks up the drug inside the brain.

24 Jun 2004

Drug combination reduces cocaine use

Researchers at the Yerkes National Primate Research Center are the first to demonstrate that a combination of drug therapies targeting the region of the brain that controls drug abuse and addiction significantly reduces cocaine use in nonhuman primates.

15 Jun 2004

New vaccine to stop cocaine addiction

Xenova Group plc has announced the presentation of results of two dose escalation Phase II studies of TA-CD, a vaccine being developed for the treatment of cocaine addiction, at the College on Problems of Drug Dependence 66th Annual Scientific Meeting in Puerto Rico, June 12-17.

14 Jun 2004

Combination drug therapies targeting brain region that controls addiction significantly reduces cocaine use in primates

Researchers at the Yerkes National Primate Research Center of Emory University are the first to demonstrate a combination of drug therapies targeting the region of the brain that controls drug abuse and addiction significantly reduces cocaine use in nonhuman primates.

24 May 2004