Endoplasmic reticulum (ER) News and Research

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TMDU researchers identify novel type of cell death in Huntington's disease

In Huntington's disease (HD), the huntingtin gene is mutated, causing progressive neuronal death.

22 Nov 2016

New survey finds 1 in 4 vacations includes visit to ER

If you've ever had to seek medical attention for an illness or an injury during a vacation, you're not alone.

21 Nov 2016

Researchers need to know more about proinsulin misfolding to better understand diabetes

According to the World Health Organization, 422 million adults across the globe have diabetes. In fact, the number of adults with the disease continues to grow each year.

17 Nov 2016

Retail clinics do not reduce emergency department visits, study finds

Despite being touted as a way to reduce emergency department visits, retail clinics opened near emergency departments had little effect on rates of low-acuity visits to them, according to the results of a study published online today in Annals of Emergency Medicine ("Association Between the Opening of Retail Clinics and Low-Acuity Emergency Department Visits").

14 Nov 2016

Collapse of MAM is common pathological hallmark to certain inherited forms of ALS

Amyotrophic lateral sclerosis (ALS) is an adult onset, fetal neurodegenerative disease that selectively affects motor neurons.

8 Nov 2016

New study shows final stages of how mitochondria regularly divide and propagate

A new University of Colorado Boulder study shows for the first time the final stages of how mitochondria, the sausage-shaped, power-generating organelles found in nearly all living cells, regularly divide and propagate.

2 Nov 2016

Study explores cost-effectiveness of school-based dental sealant programs for children

New research findings demonstrate that school-based dental sealant programs, in which students receive preventative oral care while at school, are cost-effective in protecting at-risk children's permanent teeth from decay.

27 Oct 2016

Study identifies factors that increase risk for breast cancer in young African American women

Black women under the age of 45 are at increased risk for an aggressive form of breast cancer [estrogen receptor (ER) negative] if they experienced a high number of pregnancies, never breast fed, and/or had higher waist-to-hip ratio.

19 Oct 2016

Activation of chemical with ER-β may help reduce obesity by converting white fat to brown fat

New research, published online in The FASEB Journal, suggests that activation of a chemical called Beta-LGND2 by the estrogen receptor Beta (ER-Beta) reduces obesity and metabolic diseases in mice by converting bad fat (white fat) to good fat (brown fat).

17 Oct 2016

Estrogen receptor degrader increases progression-free survival in advanced breast cancer patients

Fulvestrant significantly increases progression-free survival in women with hormone-receptor-positive advanced breast cancer, particularly those with less aggressive lower-volume disease, researchers reported at the ESMO 2016 Congress in Copenhagen

8 Oct 2016

Radiation boost provides added benefit to DCIS patients following breast-conserving surgery and WBRT

A supplemental "boost" of radiation improves local control and provides an incremental benefit in decreasing breast cancer recurrence for patients with Ductal Carcinoma In Situ (DCIS) who receive whole breast radiation therapy radiation (WBRT) following lumpectomy, according to research presented today at the 58th Annual Meeting of the American Society for Radiation Oncology.

27 Sep 2016

New study reports both young men and women with ACS have good one-year prognosis

It has become commonly accepted that women do worse than men following a heart attack or other coronary event.

26 Sep 2016

Identical twins experience unimaginable cancer

Since the day they came home from the hospital in matching newborn monkey outfits, Zane and Zac Taylor have done everything together.

23 Sep 2016

CUMC researchers uncover new details of intracellular channel that controls skeletal muscle

Using high-resolution electron microscopy, Columbia University Medical Center researchers have uncovered new details of the structure and function of an intracellular channel that controls the contraction of skeletal muscle.

22 Sep 2016

Researchers discover gene variants linked to thoracic aortic dissections

On Super Bowl Sunday, Tina Wilkins was relaxing in her recliner while she chatted on the phone with her mother and waited for the game to begin. She had recently lost 63 pounds and was in better shape than she had been in years.

20 Sep 2016

Study finds one in nine people admitted to ERs for violent injuries end up with recurrent visits

Approximately one in nine people sent to Florida emergency rooms (ERs) for injuries caused by acts of intentional violence - including shootings, stabbings, assaults, etc. - in 2010 ended up being violently injured again within two years.

16 Sep 2016

Study identifies new gene that suppresses breast cancer in mice

In recent years, the incidence of breast cancer has been increasing worldwide, and breast cancer is becoming a serious object of public concern.

13 Sep 2016

Adolescent females have low rates of pregnancy screening prior to cancer treatment

A new study indicates that adolescent females with acute leukemia have low rates of pregnancy screening prior to receiving chemotherapy that can cause birth defects.

13 Sep 2016

Discovery of signalling pathway could pave way for developing treatments targeting T-ALL leukaemia

Cooperation between Finnish and Chinese research groups has opened up new opportunities for developing treatments targeting aggressive acute lymphoblastic leukaemia (T-ALL).

2 Sep 2016

Nurse-driven protocols can shorten length of stay for patients in emergency department

Protocols allowing nurses to administer certain types of treatment in the emergency department can dramatically shorten length of stay for patients with fever, chest pain, hip fractures and vaginal bleeding during pregnancy, according to the results of a study published earlier this month in Annals of Emergency Medicine.

26 Aug 2016