Messenger RNA (mRNA) News and Research

RSS

CRIPSR identifies cell-type-specific ACE2 modifiers

Researchers compile a list of candidate genes to identify the surface abundance of functional regulators of ACE2.

9 Mar 2022

Combating COVID cytokine storm with targeted nucleic acid therapies

Researchers examine current nucleic acid-based treatments against COVID-19 and their methods of action.

6 Mar 2022

Association between booster breakthrough infections with the SARS-CoV-2 Omicron variant and time-since-vaccination

A recent study assessed the waning efficacy of the BioNTech/Pfizer BNT162b2 mRNA vaccine against the SARS-CoV-2 Omicron VOC.

1 Mar 2022

J&J-vaxxed, mRNA-boosted, and pondering a third shot

Yes, we are all exhausted by the covid pandemic. Flummoxed by the constantly shifting science and guidelines. Worried about a succession of scary new variants, each with its own name, like hurricanes.

1 Mar 2022

Omicron neutralizing titers after third BNT162b2 dose are persistent

The new study, published in the journal Cell Host and Microbe, also finds that the neutralization against Omicron remains robust at four months after the third dose of the BNT162b2 vaccine.

22 Feb 2022

New finding may aid in development of vaccines against future animal-to-human viral diseases

A future vaccine providing protection against a wide range of coronaviruses that jump from their original animal hosts to humans - including SARS-CoV-2, the cause of COVID-19 - may be possible, say Johns Hopkins Medicine researchers, based on findings from their recent study.

17 Feb 2022

Mechanism of SARS-CoV-2 Nsp1 interaction with ribosomal complexes

In a recent study posted to the bioRxiv* preprint server, the team of researchers explored the protein-protein interaction between the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) non-structural protein 1 (Nsp1) and host 40S and 43S ribosomal subunits.

15 Feb 2022

Prediction of SARS-CoV-2 epitope candidates for future vaccines

Researchers identify and investigate the presence and evolution of the SARS-CoV-2 N and S glycoprotein proteins.

15 Feb 2022

Cardiac MRI shows a similar injury pattern for vaccine-associated myocarditis

Vaccine-associated myocarditis shows a similar injury pattern on cardiac MRI compared to other causes of myocarditis, but abnormalities are less severe, according to a new study published in the journal Radiology.

15 Feb 2022

Antiviral potential of N-acylethanolamine acid amide hydrolase against SARS-CoV-2 and Zika virus

A recent study posted to the bioRxiv* pre-print server investigated the antiviral potential of N-acylethanolamine acid amidase (NAAA) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the Zika virus (ZIKV).

14 Feb 2022

Nanomedicine can be improved with proper and more predictive in vitro assays

Messenger RNA (mRNA) vaccines are a prime example of the promising field of nanomedicine. But progress in the design and application of nanoparticles as efficient delivery vehicles for biopharmaceutics containing nucleic acid or protein drug substances is, unfortunately, remarkably slow.

1 Feb 2022

New RNA therapies for the treatment of heart failure and organ fibrosis

RNA has already been making an impact in the context of the vaccine program, but the potential of RNA-based compounds is far from being fully tapped, as RNA allows for entirely new therapeutic approaches.

1 Feb 2022

Study shows mRNA booster dose eliminates immune escape observed with SARS-CoV-2 Omicron

Researchers examined total and neutralizing antibodies to the spike protein of SARS-CoV-2, and neutralizing antibodies against Washington-1 (WA-1) and variants of concern (VOC) including Beta, Delta, and Omicron in a longitudinal cohort.

31 Jan 2022

Study assesses anti-SARS-CoV-2 antibody response to mRNA-1273 vaccination over time

A new study has assessed the antibody responses to the mRNA-1273 Moderna vaccine over time.

31 Jan 2022

Preliminary study assesses durability of NAb titers against Omicron after mRNA-1273 booster

Researchers from Moderna, the developers of one key vaccine, have been investigating its ability to protect against the Omicron variant.

31 Jan 2022

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

The Damon Runyon Cancer Research Foundation has announced its newest cohort of Damon Runyon Fellows, 13 outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

29 Jan 2022

Recipients of inactivated COVID-19 vaccine (CoronaVac) can be successfully boosted with different vaccines

In the recently published study in The Lancet, first-authored by Dr. Sue Ann Costa Clemens from the University of Oxford in the United Kingdom and the University of Siena in Italy, a comprehensive analysis has been pursued on the immunogenicity and safety of both homologous and heterologous boosting after receiving the inactivated vaccine CoronaVac.

26 Jan 2022

Study finds overexpression of 3 SARS-CoV-2 genes could globally compromise transcriptome of human pluripotent stem cell-derived cardiomyocytes

In a recent study, whole mRNA-seq was used to investigate the global effects of SARS-CoV-2 viral genes Nsp6, Nsp8, and M on the transcriptome of hPSC-CMs.

26 Jan 2022

Gene therapy can provide long-lasting therapeutic benefit in Huntington's disease

Gene therapy targeting the messenger RNA (mRNA) of the mutated huntingtin gene (HTT) can provide long-lasting therapeutic benefit in Huntington's disease after a single administration.

25 Jan 2022

Lower risk of vaccine-breakthrough infections for mRNA-1273 recipients

Recently, a team of researchers examined breakthrough infections, hospitalizations, and mortality rates in double-dose messenger RNA (mRNA) vaccine recipients in a research letter published in the Journal of American Medical Association (JAMA).

24 Jan 2022

Messenger RNA (mRNA) News and Research

CRIPSR identifies cell-type-specific ACE2 modifiers

Combating COVID cytokine storm with targeted nucleic acid therapies

Association between booster breakthrough infections with the SARS-CoV-2 Omicron variant and time-since-vaccination

J&J-vaxxed, mRNA-boosted, and pondering a third shot

Omicron neutralizing titers after third BNT162b2 dose are persistent

New finding may aid in development of vaccines against future animal-to-human viral diseases

Mechanism of SARS-CoV-2 Nsp1 interaction with ribosomal complexes

Prediction of SARS-CoV-2 epitope candidates for future vaccines

Cardiac MRI shows a similar injury pattern for vaccine-associated myocarditis

Antiviral potential of N-acylethanolamine acid amide hydrolase against SARS-CoV-2 and Zika virus

Nanomedicine can be improved with proper and more predictive in vitro assays

New RNA therapies for the treatment of heart failure and organ fibrosis

Study shows mRNA booster dose eliminates immune escape observed with SARS-CoV-2 Omicron

Study assesses anti-SARS-CoV-2 antibody response to mRNA-1273 vaccination over time

Preliminary study assesses durability of NAb titers against Omicron after mRNA-1273 booster

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

Recipients of inactivated COVID-19 vaccine (CoronaVac) can be successfully boosted with different vaccines

Study finds overexpression of 3 SARS-CoV-2 genes could globally compromise transcriptome of human pluripotent stem cell-derived cardiomyocytes

Gene therapy can provide long-lasting therapeutic benefit in Huntington's disease

Lower risk of vaccine-breakthrough infections for mRNA-1273 recipients

How to solve the hidden bottleneck in lipid nanoparticle development eBook

Latest eBooks

Editorial Focus eBook - Spatial and single-cell omics (1st edition)

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Improving healthcare sustainability through carbon data

A New Approach to Preventing Bladder Cancer Recurrence

Bringing real-time analytics to downstream bioprocess monitoring