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Mapping the evolution of AI in organelle segmentation

In organelle imaging, segmentation aims to accurately delineate pixels or voxels corresponding to target organelles from background, noise, and other cellular structures in microscopy images, thereby generating masks suitable for quantitative analysis. Robust segmentation is foundational to downstream quantification, including morphological characterization, spatial distribution analysis, temporal trajectory tracking, and the detection of key biological events.

10 Mar 2026

Protein aggregates in the liver may protect against alcohol-induced damage

Alcohol-associated liver disease (ALD) remains a leading cause of cirrhosis and liver-related mortality worldwide, with few effective therapies.

9 Mar 2026

Understanding PIEZO2 mutations and sensory disorders

Every time we feel a gentle tap on the skin, specialized nerve cells convert that physical force into an electrical signal that the brain can interpret as touch. While scientists have long known that a protein called PIEZO2 acts as a key sensor for touch, it remained unclear why PIEZO2 is specialized for the localized mechanical forces experienced by sensory neurons, whereas its close relative PIEZO1 responds to broader mechanical stresses such as those generated when cells stretch, as occurs in blood vessels.

9 Mar 2026

Unmasking the hyperactive circuitry of early Alzheimer’s

Neuroscientists at King's College London have pinpointed a mechanism behind the increased neural connectivity observed in the very early stages of Alzheimer's disease.

9 Mar 2026

Case report describes treatment of rare calcified solid pseudopapillary pancreatic tumor

A new case report was published in Volume 13 of Oncoscienceon February 7, 2026, titled "Massive calcified solid pseudopapillary neoplasm of the pancreatic head."

6 Mar 2026

Tubulin prevents toxic protein clumps linked to neurodegeneration

Researchers at Baylor College of Medicine have discovered a potential new strategy to fight back against Alzheimer's and Parkinson's diseases, conditions that are linked to the toxic accumulation of Tau and alpha synuclein protein clumps in the brain.

6 Mar 2026

Virtual immunostaining method improves detection of vascular invasion in thyroid cancer

In a groundbreaking study published in BME Frontiers, researchers from the University of California, Los Angeles (UCLA), in collaboration with international partners, have developed a deep learning-based virtual multiplexed immunostaining (mIHC) method.

6 Mar 2026

New microscope captures 3D blood flow and oxygenation at single-cell resolution

The brain relies on real-time delivery of oxygen and nutrients through its microvasculature, which threads through neural tissue like electrical wires.

5 Mar 2026

Enhancing myelination may help sustain therapeutic effects of psychedelic-assisted PTSD treatment

Post-traumatic stress disorder (PTSD) is not only characterized by strongly encoded traumatic memories, but also by disrupted coordination across brain networks.

4 Mar 2026

Study reveals hydration energetics as key to nanoparticle performance in medicine

Researchers at Arizona State University have uncovered a key scientific principle that governs how what's coated on the surfaces of engineered nanoparticles may ultimately control how they work in our bodies.

2 Mar 2026

Protein partnership enhances innate immune sensing of viral RNA

Study reveals how two proteins cooperate in a key early step of antiviral detection, as reported by researchers at Science Tokyo.

27 Feb 2026

Unexpected behavior observed during interactions between immune cells and dying cells

Over the years, cell biology has built a detailed picture of how cells compartmentalize their internal functions. Central to this organization is the nucleus, which houses the genetic material and is separated from the cytoplasm by a robust nuclear envelope.

25 Feb 2026

ATG14 found to be a critical defender against hepatic injury and fibrosis

Autophagy is indispensable for maintaining hepatocyte integrity, metabolic homeostasis, and survival. While several autophagy-related proteins have been studied in hepatic physiology, the specific role of Autophagy Related 14 (ATG14) in liver health has remained unclear.

24 Feb 2026

Novel antimicrobial peptides from dromedary camels offer hope against antibiotic resistance

Antimicrobial resistance poses a growing global health crisis, with few new antibiotics in development.

22 Feb 2026

Scientists reveal how the body senses cold and menthol

When you step outside on a winter morning or pop a mint into your mouth, a tiny molecular sensor in your body springs into action, alerting your brain to the sensation of cold.

22 Feb 2026

Multicolor electron microscopy reveals proteins and cell architecture at nanoscale resolution

Scientists have developed a new imaging technique that uses a novel contrast mechanism in bioimaging to merge the strengths of two powerful microscopy methods, allowing researchers to see both the intricate architecture of cells and the specific locations of proteins-all in vivid color and at nanometer resolution.

22 Feb 2026