Norepinephrine News and Research

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Autonomic nervous system directly controls stem cell proliferation, study shows

Somatic stem cells are microscopic workhorses, constantly regenerating cells throughout the body: skin and the lining of the intestine, for example. And to University of Illinois neuroscientists, they represent untapped potential.

17 Oct 2018

Cancer cells hijack communication between fallopian tube and ovary to drive tumor growth

New research from the University of Illinois at Chicago shows that cancer cells in the fallopian tube affect normal chemical signaling between reproductive tissues and stimulate the release of norepinephrine, a small molecule hormone, from the ovary.

10 Oct 2018

VCU researchers to study how a gene could influence cognitive decline during chemotherapy

With the help of a $2.1 million grant, Virginia Commonwealth University School of Nursing researchers will study how a gene that regulates estrogen and neurotransmitter levels could be tied to cognitive decline in patients undergoing chemotherapy for breast and endometrial cancers.

27 Sep 2018

Researchers use larval zebrafish model to reveal role of locus coeruleus in anesthesia

The application of general anesthesia in clinical therapy has been an indispensable part of modern medicine for more than a century. However, due to the complexity of the brain and the extensive actions of general anesthetic drugs, neural mechanisms underlying general anesthesia have remained a mystery.

19 Sep 2018

Mechanically ventilated patients treated with vasopressor may develop ICU-related weakness

At least 25 percent of critically ill patients who receive mechanical ventilation in intensive care units develop muscular weakness severe enough to impair their quality of life.

11 Sep 2018

Stress can permanently and profoundly impact connectivity of developing nerves

Scientists stunted the puberty of male worms by starving them before they underwent sexual maturation. In a study funded by the National Institutes of Health, the scientists suggested that stress from starvation even days before sexual maturation prevented normal changes in the wiring patterns of key neuronal circuits, which caused adult male worms to act immature.

7 Sep 2018

Sunovion receives Complete Response Letter from FDA for dasotraline NDA

Sunovion Pharmaceuticals Inc. today announced that the U.S. Food and Drug Administration issued a Complete Response Letter for the New Drug Application for dasotraline, a novel dual-acting dopamine and norepinephrine reuptake inhibitor, for the treatment of attention-deficit hyperactivity disorder.

3 Sep 2018

Pivotal study of dasotraline in adults with binge eating disorder meets primary endpoint

Sunovion Pharmaceuticals Inc. today announced that a study evaluating the efficacy and safety of dasotraline in adults with moderate to severe binge eating disorder met its primary endpoint, demonstrating a statistically significant decrease in number of binge days per week from baseline to Week 12 in the group treated with dasotraline 6 mg/day versus the placebo-treated group.

25 Jul 2018

Study looks into mechanisms that control sleep and wakefulness

Sleep is an autonomic process and is not always under our direct, voluntary control. Awake or asleep, we are basically under the regulation of two biological processes: sleep homeostasis, commonly known as 'sleep pressure', and the circadian rhythm, otherwise known as the 'body clock'.

20 Jul 2018

Neurotransmitter responsible for brain arousal plays vital role in early sensory perceptions

Being aware of our surroundings is a fundamental aspect of our existence. But what in our biological makeup determines how we access and interpret the endless stream of information around us?

10 Jul 2018

Researchers work to identify areas of the brain that help us wake up

Philosophers have pondered the nature of consciousness for thousands of years. In the 21st century, the debate over how the brain gives rise to our everyday experience continues to puzzle scientists.

22 Jun 2018

Researchers identify new form of depression

In a new study, researchers from Hiroshima University have identified a new form of depression that could be used to inform a new generation of treatments.

11 Jun 2018

Study: Immunization with beneficial bacteria can have long-lasting anti-inflammatory effects on the brain

Immunization with beneficial bacteria can have long-lasting anti-inflammatory effects on the brain, making it more resilient to the physical and behavioral effects of stress, according to new research by University of Colorado Boulder scientists.

7 Jun 2018

FDA OKs first non-opioid drug for adults with opioid withdrawal symptoms

The United States Food and Drugs Administration (FDA), in a statement this week, approved a new drug Lucemyra (lofexidine hydrochloride) for the treatment and alleviation of opioid symptom withdrawal symptoms in adults in whom the drugs have been withdrawn abruptly.

17 May 2018

FDA approves new treatment to mitigate opioid withdrawal symptoms in adults

The U.S. Food and Drug Administration today approved Lucemyra (lofexidine hydrochloride) for the mitigation of withdrawal symptoms to facilitate abrupt discontinuation of opioids in adults.

17 May 2018

Researchers explain neurophysiological link between breathing and attention

It has long been claimed by Yogis and Buddhists that meditation and ancient breath-focused practices, such as pranayama, strengthen our ability to focus on tasks.

11 May 2018

Sympathetic nerve activity increases during stress in people with chronic anxiety, study finds

Sympathetic nerve activity to skeletal muscle blood vessels--a function of the nervous system that helps regulate blood pressure--increases during physiological and mental stress in people with chronic anxiety, a new study finds.

4 May 2018

Researchers suggest alternative therapy for heart attack patients with beta blocker intolerance

Beta blockers have become a prescription drug staple for recovering heart attack patients. However, these blood pressure-reducing medications cannot be tolerated by many patients who are at higher risk for developing cardiovascular disease, including those with chronic obstructive pulmonary disease and asthma, the elderly, and diabetics.

10 Apr 2018

SSRIs may be more effective option for treating anxious youth, UC research shows

For children and adolescents who require medication to treat anxiety, there are two primary classes of antidepressants that are prescribed: selective serotonin reuptake inhibitors and selective serotonin-norepinephrine reuptake inhibitors.

19 Mar 2018

Nervous system can "put the brakes" on immune response and prevent excessive inflammation

Cells in the nervous system can "put the brakes" on the immune response to infections in the gut and lungs to prevent excessive inflammation, according to research by Weill Cornell Medicine scientists. This insight may one day lead to new ways to treat diseases caused by unchecked inflammation, such as asthma and inflammatory bowel disease.

2 Mar 2018