Norepinephrine News and Research

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Scientists develop interactive model to fast-track research and treatment of schizophrenia

It's called mental imbalance for a reason. Sanity hangs, in part, in the gentle balance of chemicals strung together within regions of the brain in an intricate matrix.

4 Aug 2016

Overcoming gene silencing barriers to target neurological conditions: an interview with Dr Errol de Souza

Many gene mutations that cause neurological disorders have been identified. For example, in a rare neurological disorder such as Huntington’s disease, an autosomal dominant mutation through expansion of CAG (cytosine-adenine-guanine) triplet repeats in the gene coding for the Huntingtin protein results in abnormal protein production.

1 Aug 2016

Scientists reveal how manipulating novel target in the brain could lead to new therapies for depression

Northwestern Medicine scientists have shown how manipulating a novel target in the brain using gene therapy could lead to new treatments for depression.

12 Jul 2016

Exercise during pregnancy can have benefits for mom and baby

Researchers collected and re-examined clinical trial data on exercise during pregnancy and whether it plays a role in preterm birth, and found that exercise is safe and does not increase the risk of preterm birth.

7 Jul 2016

Cells grown from pluripotent stem cells can pair with heart muscle cells to stimulate contractions

Researchers at Johns Hopkins report that a type of lab-grown human nerve cells can partner with heart muscle cells to stimulate contractions.

17 Jun 2016

Disruptive sleep patterns could raise heart disease risk in shift workers and insomniacs

People who suffer from a lack of sleep and disordered sleep cycles could be increasing their chances of developing cardiovascular disease, according to a study in the American Heart Association’s Journal Hypertension.

7 Jun 2016

Vocal learning in songbirds sheds more light on developmental disorders in humans

Adult songbirds modify their vocalizations when singing to juveniles in the same way that humans alter their speech when talking to babies. The resulting brain activity in young birds could shed light on speech learning and certain developmental disorders in humans, according to a study by McGill University researchers.

1 Jun 2016

New understanding of neurotransmitter transporter mechanism gives hope for treating depression, addicition

When nerve cells have to communicate with each other in our brains, it involves release of small signal molecules, the so-called neurotransmitters, which act as chemical messengers in specific points of contact between nerve cells, called synapses.

27 May 2016

Early-life stress may lead to functional dyspepsia in adulthood

Traumatic events early in life can increase levels of norepinephrine—the primary hormone responsible for preparing the body to react to stressful situations—in the gut, increasing the risk of developing chronic indigestion and anxiety during adulthood, a new study in American Journal of Physiology—Gastrointestinal and Liver Physiology reports.

27 May 2016

CAMH, Impel NeuroPharma partner to advance novel treatment to alleviate depression

The Centre for Addiction and Mental Health and Impel NeuroPharma have signed a licensing agreement to advance a new neuropeptide-based therapeutic approach shown to be effective in treating depression.

1 Mar 2016

Researchers identify brain region where Alzheimer's disease starts

A critical but vulnerable region in the brain appears to be the first place affected by late onset Alzheimer's disease and may be more important for maintaining cognitive function in later life than previously appreciated, according to a new review of the scientific literature.

17 Feb 2016

Researchers report first-ever link between noradrenergic neurons and vulnerability to depression

The team of Bruno Giros, a researcher at the Douglas Mental Health University Institute and professor of psychiatry at McGill University, reports the first-ever connection between noradrenergic neurons and vulnerability to depression. Published in the journal Nature Neuroscience, this breakthrough paves the way for new depression treatments that target the adrenergic system.

15 Feb 2016

Wayne State inks exclusive license agreement with TRImaran Pharma for novel class of drugs

Wayne State University recently entered into an exclusive license agreement with TRImaran Pharma Inc. for a class of novel drugs developed at Wayne State University that aims to offer hope in the treatment of post-traumatic stress disorders (PTSD), depression, ADHD and other neurological disorders.

9 Feb 2016

Neurons protect intestinal tissue from over-inflammation

The immune system exercises constant vigilance to protect the body from external threats--including what we eat and drink. A careful balancing act plays out as digested food travels through the intestine. Immune cells must remain alert to protect against harmful pathogens like Salmonella, but their activity also needs to be tempered since an overreaction can lead to too much inflammation and permanent tissue damage.

25 Jan 2016

Drinking one 16-ounce energy drink may increase risk of cardiovascular events in young adults

New research shows that drinking one 16-ounce energy drink can increase blood pressure and stress hormone responses significantly. This raises the concern that these response changes could increase the risk of cardiovascular events, according to a study presented today at the American Heart Association's Scientific Sessions 2015.

10 Nov 2015

Energy drink consumption linked with serious cardiovascular events

Anna Svatikova, M.D., Ph.D., of the Mayo Clinic, Rochester, Minn., and colleagues randomly assigned 25 healthy volunteers (age 18 years or older) to consume a can (480 mL; 16 fl. oz.) of a commercially available energy drink (Rockstar; Rockstar Inc) and placebo drink within 5 minutes, in random order on 2 separate days, maximum 2 weeks apart.

9 Nov 2015

More research needed before recommending antidepressants, Alzheimer's disease drugs for stroke recovery: Study

Evidence is mounting that drugs used to treat depression and Alzheimer's disease also can help patients recover from strokes. But there are conflicting findings from studies of these and other drugs given to recovering stroke patients.

22 Oct 2015

Endocrine Society issues Clinical Practice Guideline on treatment of menopausal symptoms

The Endocrine Society today issued a Clinical Practice Guideline (CPG) on identifying women who are candidates for treatment of menopausal symptoms and selecting the best treatment options for each individual.

8 Oct 2015

NAMS panel provides recommendations to help women manage menopause-associated vasomotor symptoms

Some three-quarters of North American women have menopausal hot flashes, but many cannot use hormones for medical reasons or choose not to. Numerous products and techniques are promoted for hot flashes, but do they work, and are they safe? To answer these questions, a North American Menopause Society panel of experts weighed the evidence and made recommendations in a position statement, "Nonhormonal management of menopause-associated vasomotor symptoms," published online today in the Society's journal, Menopause.

23 Sep 2015

Brain cells in Parkinson's disease die prematurely, burning out like an overheating motor

The death of brain cells in Parkinson's disease may be caused by a form of cellular energy crisis in neurons that require unusually high quantities of energy to carry out their job of regulating movement, researchers at the University of Montreal reported today.

28 Aug 2015