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New model improves short- and long-term disease risk prediction

Researchers developed ALADYNOULLI, a Bayesian generative model that combines longitudinal health records, age, and polygenic risk to identify reproducible disease signatures across more than 683,000 participants. In UK Biobank testing, the framework achieved stronger short- and long-term risk discrimination than established clinical scores while revealing disease subgroups and genetic associations.

16 Jul 2026

Study links expanding GLP-1 use with rising overall costs

As use of GLP-1s surged across the U.S., average total payments per user also climbed sharply, according to a new Northwestern University study that analyzed national trends in GLP-1 use and spending between 2017 and 2022.

16 Jul 2026

Targeting ZBP1 may overcome cancer immunotherapy resistance

A new Review published in the open-access journal Ferroptosis and Oxidative Stress highlights Z-nucleic acid-binding protein 1 (ZBP1) as an emerging innate immune sensor that converts genomic stress into potent antitumor immunity.

16 Jul 2026

Researchers identify immune cell receptor that drives organ aging process

We may age at different rates, but none of us escapes aging. A study in mice and in human cells by Stanford Medicine researchers pins much of the blame on a particular type of immune cell's increased inability, with advancing age, to gobble up another immune cell type.

16 Jul 2026

New biological feedback loop helps the immune system attack colorectal cancers

A subset of cancers, known as microsatellite instability (MSI) and deficient DNA mismatch repair (dMMR) cancers, are more visible to the immune system than others.

16 Jul 2026

PET imaging reveals widespread brain receptor deficits in schizophrenia

A groundbreaking study using positron emission tomography (PET) imaging has found that patients with schizophrenia had significantly lower muscarinic acetylcholine M1 receptor availability (~13% to 19%) across multiple brain regions compared with healthy individuals.

16 Jul 2026

Weill Cornell Medicine receives DoD grant to target triple-negative breast cancer

Weill Cornell Medicine has received a $2.5 million, three-year grant from the Department of Defense (DoD) to develop therapies with fewer side effects for triple-negative breast cancer, one of the most aggressive and difficult-to-treat breast cancers.

16 Jul 2026

Weight loss drugs may reduce binge eating disorder symptoms

Drugs commonly used for weight loss, known as GLP-1 receptor agonists, have been found to reduce the key symptoms of binge eating disorder, in a new review of evidence led by University College London (UCL) researchers.

15 Jul 2026

Researchers uncover new T cell attack mechanism against acute myeloid leukemia

Researchers at The University of Texas MD Anderson Cancer Center have discovered a new way in which T cells attack acute myeloid leukemia (AML) cells, which may help explain why AML is particularly sensitive to immune-based treatments and could guide the development of future cancer immunotherapies.

15 Jul 2026

Bile acid buildup linked to aggressive breast cancer progression

A buildup of bile acids caused by an unhealthy gut can drive breast cancer to other parts of the body, new University of Virginia Comprehensive Cancer Center research reveals.

15 Jul 2026

Lactoferrin yogurt helps preserve iron stores in women with gestational diabetes

In a double-blind pilot trial, lactoferrin-enriched yogurt added to routine iron supplementation helped prevent ferritin decline in pregnant women with gestational diabetes and reduced iron stores. The intervention was well tolerated and produced modest changes in selected gut bacteria, but did not significantly improve anemia or metabolic outcomes.

15 Jul 2026

Researchers rank 11 preeclampsia therapies as top candidates for further development

Researchers ranked 83 preclinical candidates for preventing or treating preeclampsia and eclampsia, identifying 11 as having high potential for further development. The analysis also revealed limited target diversity, moderate bias, inactive programs, and animal models that may not fully represent human pregnancy

15 Jul 2026

Brain’s immune cells play key role in maintaining stability of neuronal networks in Alzheimer's disease

Researchers at Trinity College Dublin have discovered that microglia – the main immune cells of the brain – play a critical role in maintaining the stability of neuronal networks in Alzheimer's disease.

15 Jul 2026

Self-assembling antibody drugs successfully target multiple cancer receptors

Modern anticancer medications that combine tumor-fighting drugs with proteins that specifically target cancer cells are a relatively new class of drug, often given to patients for whom standard chemotherapy has not worked.

15 Jul 2026

GLP-1 receptor activation linked to lower depression and bipolar disorder odds

Genetic analyses linked BMI-related GLP-1 receptor activation to better mental well-being and lower odds of major depressive disorder and bipolar disorder. The findings do not prove that GLP-1 receptor agonist drugs treat psychiatric conditions, and randomized clinical trials are still needed.

15 Jul 2026

Cell death crosstalk network drives acute respiratory distress syndrome

Acute respiratory distress syndrome (ARDS) remains one of the deadliest complications of severe infections, sepsis, trauma, and viral pneumonia, yet decades of research have produced few targeted therapies capable of improving patient outcomes.

14 Jul 2026

Semaglutide dose may matter more than weight loss for heart health

The study shows semaglutide's cardiovascular benefits are more closely tied to attained dose than weight loss, challenging existing treatment assumptions.

14 Jul 2026

Researchers uncover hidden mechanism behind cancer-linked SPOP mutations

Mutations to the protein SPOP are widespread in cancer, yet many remain poorly understood. To address this gap, St. Jude Children's Research Hospital scientists obtained structures of SPOP in both the presence and absence of these mutations.

13 Jul 2026

GLP-1 weight loss may reduce first-impression penalties in relationships and hiring

An NBER working paper found that GLP-1 initiation and associated weight loss were followed by higher partnership formation among initially single women and greater employment entry among women who were not employed. The findings suggest that part of the female obesity penalty may arise when prospective partners and employers form first impressions, although the observational analysis did not directly prove discrimination

13 Jul 2026

Nearly one in 10 Britons use or want weight-loss medication

The prevalence of GLP-1 receptor agonists for weight management in Great Britain highlights public interest and concerns over safety and prescribing practices.

13 Jul 2026