VEGF News and Research

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VEGF is a substance made by cells that stimulates new blood vessel formation. Also called vascular endothelial growth factor.

Potentially promising therapeutic combination for renal cell carcinoma uncovered

Renal cell carcinoma (RCC) is the most common form of cancer of the kidney. In 2018, there were an estimated 403,000 new cases of RCC and 175,000 deaths due to kidney cancer worldwide.

20 Jan 2021

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Reprogramming the rich connective tissue microenvironment of a liver cancer known as intrahepatic cholangiocarcinoma (ICC) inhibits its progression and resistance to standard chemotherapy in animal models, researchers from Massachusetts General Hospital have found.

12 Jan 2021

Researchers identify adenovirus gene therapy for placental insufficiency

A new study identified an adenovirus gene therapy vector carrying a VEGF isoform. It can improve uterine blood flow in placental insufficiency, as reported in the peer-reviewed journal Human Gene Therapy.

15 Dec 2020

Surgical and drug treatment approaches are equally effective for diabetic eye disease

Surgical and injectable drug approaches are equally effective for treatment of bleeding inside the eye from proliferative diabetic retinopathy (PDR), according to a National Eye Institute (NEI)-supported clinical study from the DRCR Retina Network (DRCR.net).

15 Dec 2020

Unique inhibitory protein may suppress the formation of cancer cells

Researchers from Tokyo Medical and Dental University (TMDU) identify a novel role for a protein, vasohibin-1, in preventing cancer cells from spreading

15 Dec 2020

Findings about primary cilia may be relevant for transplantation therapies in diabetes

A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells in the pancreatic islets.

5 Dec 2020

PTC299 inhibits SARS-CoV-2 replication and suppresses production of inflammatory cytokines

In an article published in the journal Virus Research, a team of researchers from various US institutions discussed their study that evaluated the antiviral activity of PTC299 against a group of RNA viruses in vitro.

1 Dec 2020

Combination therapy found to be effective against treatment-resistant hepatocellular carcinoma

A combination cancer therapy that is effective against treatment-resistant hepatocellular carcinoma (HCC) by inhibiting tumor growth and increasing survival has been identified by researchers at Massachusetts General Hospital.

30 Nov 2020

Study shows new route for treating myocardial infarction

When the heart develops, some of its coronary blood vessels develop from cells lining the inner surface of the heart's ventricular chambers (endocardium). Novel

19 Nov 2020

Preeclampsia-related placental gene expression may be associated with vitamin D status

According to the World Health Organization, preeclampsia affects between 2% to 8% of pregnancies. It can cause serious, sometimes fatal, complications in the mother and child.

10 Nov 2020

Two studies find age as a primary factor in melanoma treatment resistance

Age may cause identical cancer cells with the same mutations to behave differently. In animal and laboratory models of melanoma cells, age was a primary factor in treatment response.

2 Nov 2020

Novel mechanism increases arterial diameter, allows increased inflow

Upon a heart infarct or stroke, rapid restoration of blood flow, and oxygen delivery to the hypoperfused regions is of eminent importance to prevent further damage to the heart or brain. Arterial diameter is a critical determinant of blood flow conductance.

28 Oct 2020

Scripps Research scientists uncover potential new strategy for treating eye diseases

Scientists at Scripps Research have uncovered a potential new strategy for treating eye diseases that affect millions of people around the world, often resulting in blindness.

27 Oct 2020

Age can affect response to adjuvant treatment among patients with resected melanoma

Younger patients with resected melanoma had some benefit from adjuvant treatment with the anti-VEGF therapeutic bevacizumab (Avastin) while older patients with resected melanoma did not

23 Oct 2020

Study provides new insight into unknown effects of factors that regulate blood vessel formation

A new study by researchers at the University of Eastern Finland provides novel insight into the previously unknown effects of factors regulating blood vessel formation.

14 Oct 2020

SARS-CoV-2 spike protein may induce analgesia

A recent study published in the journal Pain in October 2020 adds another piece to the puzzle, showing that the virus is capable of dulling pain pathways. This may contribute to its early and extensive spread.

7 Oct 2020

Phase 2 clinical trial to examine the effects of razuprotafib on COVID-19 patients

Researchers at the University of Cincinnati and UC Health will host a Phase 2 clinical trial (NCT04511650) to examine the effects of a drug that targets blood vessel inflammation and injury in patients with COVID-19.

22 Sep 2020

A novel gene involved in primary lymphedema identified

The Human Molecular Genetics laboratory of the de Duve Institute (UCLouvain), headed by Professor Miikka Vikkula, recently identified mutations in a novel gene, ANGPT2, responsible for primary lymphedema.

10 Sep 2020

Parkinson's disease drug may improve vision in patients with age-related macular degeneration

Investigators have determined that treating patients with an advanced form of age-related macular degeneration (AMD) with levodopa, a safe and readily available drug commonly used to treat Parkinson's disease, stabilized and improved their vision.

10 Sep 2020

RNA-targeting compound restarts a healing factor silenced by heart attack

A heart attack can leave parts of the heart permanently scarred and stiff, resulting in prolonged disability and potential progression toward heart failure. Scientists have studied various ways to repair or regenerate such damaged heart tissue, with limited success.

24 Aug 2020

VEGF News and Research

Further Reading

Potentially promising therapeutic combination for renal cell carcinoma uncovered

Researchers discover a new approach to inhibit intrahepatic cholangiocarcinoma

Researchers identify adenovirus gene therapy for placental insufficiency

Surgical and drug treatment approaches are equally effective for diabetic eye disease

Unique inhibitory protein may suppress the formation of cancer cells

Findings about primary cilia may be relevant for transplantation therapies in diabetes

PTC299 inhibits SARS-CoV-2 replication and suppresses production of inflammatory cytokines

Combination therapy found to be effective against treatment-resistant hepatocellular carcinoma

Study shows new route for treating myocardial infarction

Preeclampsia-related placental gene expression may be associated with vitamin D status

Two studies find age as a primary factor in melanoma treatment resistance

Novel mechanism increases arterial diameter, allows increased inflow

Scripps Research scientists uncover potential new strategy for treating eye diseases

Age can affect response to adjuvant treatment among patients with resected melanoma

Study provides new insight into unknown effects of factors that regulate blood vessel formation

SARS-CoV-2 spike protein may induce analgesia

Phase 2 clinical trial to examine the effects of razuprotafib on COVID-19 patients

A novel gene involved in primary lymphedema identified

Parkinson's disease drug may improve vision in patients with age-related macular degeneration

RNA-targeting compound restarts a healing factor silenced by heart attack

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