Angiotensin News and Research

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Angiotensin is an oligopeptide in the blood that causes vasoconstriction, increased blood pressure, and release of aldosterone from the adrenal cortex. It is a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It plays an important role in the renin-angiotensin system.

SARS-CoV-2 spike-antibody binding strength and hydrogen bond numbers are temperature dependent, study finds

A new preprint on the bioRxiv* server describes the interactions between the binding spike protein of the SARS-CoV-2 virus with the antibodies. Earlier studies have addressed the similarity in the 3D structures of the spike protein in the two SARS viruses as seen on cryo-EM.

24 Dec 2020

Could engineered red blood cells be an effective antiviral against SARS-CoV-2?

In a new study, released on the bioRxiv* preprint server, a team of researchers explores the antiviral potential of red blood cells against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative pathogen of COVID-19.

24 Dec 2020

Animal study suggests palmitoylation inhibitor reduces virulence of SARS-CoV-2

A new study preprint on the bioRxiv* server demonstrates the ability of a fatty acid synthase inhibitor to improve the survival of mice infected with murine hepatitis virus. In so doing, it adds to the sum of knowledge about the relationship of SARS-CoV-2 with cholesterol metabolism in the host cell.

24 Dec 2020

A common compound in mouthwashes found to inhibit SARS-CoV-2 in vitro

Researchers found that cetylpyridinium chloride, found in most mouthwashes, lowers infectivity of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro, likely by inhibiting viral fusion with target cells. With more tests to prove validity, mouthwashes could be a simple, cheap way of curbing transmission.

24 Dec 2020

COVID-19 severity could be linked to genetic variance

A new study describes some potentially important genetic factors in the host that may shape the clinical symptoms and signs of the disease.

23 Dec 2020

Scientists isolate anti-COVID-19 nanobodies produced by a llama

National Institutes of Health researchers have isolated a set of promising, tiny antibodies, or "nanobodies," against SARS-CoV-2 that were produced by a llama named Cormac.

22 Dec 2020

Prior use of renin-angiotensin system inhibitors linked to reduced risk of death in older COVID-19 patients with hypertension

A new study, appearing as a preprint on the medRxiv* server, demonstrates the protective effect of drugs in older COVID-19 patients with hypertension.

21 Dec 2020

SARS-CoV-2 spike protein remains remarkably conserved among 37 variants from Hong Kong

As the coronavirus disease 2019 (COVID-19) pandemic continues to intensify in many parts of the world, vaccine development is proceeding apace.

21 Dec 2020

Study may help explain how COVID-19 increases stroke risk

A UCLA-led study may help explain how COVID-19 increases the risk for stroke. Scientists made the finding by running fluid spiked with a COVID-19-like protein through a 3D-printed model of the arteries of a patient who had suffered a stroke.

18 Dec 2020

Higher COVID-19 mortality among certain groups in Colombia linked to structural inequalities

Researchers at the Ministry of Health and Social Protection in Bogotá, Colombia, provided evidence of socioeconomic inequalities in COVID-19 deaths in terms of age, sex, ethnicity, type of health insurance regime, and socioeconomic status.

18 Dec 2020

Rapid point-of-care lateral flow assay to assess the neutralizing activity of plasma against SARS-CoV-2

A new paper describes the development and validation of a rapid test to measure the neutralizing activity of serum against COVID-19 using a drop of blood.

18 Dec 2020

Cholesterol in the plasma membrane is essential for SARS-CoV-2 entry and syncytia formation

A preprint indicates that SARS-CoV-2 requires cholesterol to accomplish entry into the host cells and membrane fusion.

17 Dec 2020

SARS-CoV-2 surface proteins alter the expression of key chemokines and cytokines in cell lines

Researchers from the Washington University School of Medicine, United States of America, recently demonstrated that the SARS-CoV-2 surface proteins alone triggered innate cell activity and the interferon signaling pathway.

17 Dec 2020

SARS-CoV-2 spike deletion ΔH69/ΔV70 shows repeated emergence and spread

Since the COVID 19 pandemic, it has been established that the causative virus, SARS-CoV-2 gains entry to the target host cell via its spike glycoprotein.

17 Dec 2020

HDL nanoparticles prevent cholesterol movement at membrane receptor to inhibit entry of SARS-CoV-2 pseudovirus in cell culture

As researchers strive to find safe therapeutics for COVID 19, a study suggests that preventing the movement of cholesterol may inhibit viral entry by up to 80%.

17 Dec 2020

Study shows an inflammatory response in the mice brain is responsible for severe COVID-19

Researchers demonstrated that neuroinvasion and encephalitis caused by SARS-CoV-2 is associated with significant mortality in a special mouse model.

17 Dec 2020

Why are some groups more vulnerable to COVID-19?

News-Medical speaks to Dr. Jaswinder Singh about his research surrounding why some groups are more susceptible to severe cases of COVID-19.

17 Dec 2020

Traditional herbal medicine Respiratory Detox Shot (RDS) inhibits SARS-CoV, SARS-CoV-2 and Influenza A infection in vitro

As researchers continue to search for antivirals to counter COVID-19, a study presents the potential utility of a decoction called Respiratory Detox Shot (RDS).

16 Dec 2020

Autoimmune condition biomarkers promote SARS-CoV-2 viral entry, study finds

Researchers have reported that the autoimmune PTPN2 risk variant rs1893217 promotes the expression of the SARS-CoV-2 receptor, ACE2, and thus promotes cellular entry, which is mediated by SARS-CoV-2 spike S protein.

16 Dec 2020

Neanderthal gene variant increases risk of severe COVID-19

Researchers in Germany have conducted a study showing that between 2 and 8% of people in Eurasia carry a genetic variant inherited from Neanderthals that significantly increases the risk of becoming critically ill with coronavirus disease 2019 (COVID-19).

15 Dec 2020

Angiotensin News and Research

Further Reading

SARS-CoV-2 spike-antibody binding strength and hydrogen bond numbers are temperature dependent, study finds

Could engineered red blood cells be an effective antiviral against SARS-CoV-2?

Animal study suggests palmitoylation inhibitor reduces virulence of SARS-CoV-2

A common compound in mouthwashes found to inhibit SARS-CoV-2 in vitro

COVID-19 severity could be linked to genetic variance

Scientists isolate anti-COVID-19 nanobodies produced by a llama

Prior use of renin-angiotensin system inhibitors linked to reduced risk of death in older COVID-19 patients with hypertension

SARS-CoV-2 spike protein remains remarkably conserved among 37 variants from Hong Kong

Study may help explain how COVID-19 increases stroke risk

Higher COVID-19 mortality among certain groups in Colombia linked to structural inequalities

Rapid point-of-care lateral flow assay to assess the neutralizing activity of plasma against SARS-CoV-2

Cholesterol in the plasma membrane is essential for SARS-CoV-2 entry and syncytia formation

SARS-CoV-2 surface proteins alter the expression of key chemokines and cytokines in cell lines

SARS-CoV-2 spike deletion ΔH69/ΔV70 shows repeated emergence and spread

HDL nanoparticles prevent cholesterol movement at membrane receptor to inhibit entry of SARS-CoV-2 pseudovirus in cell culture

Study shows an inflammatory response in the mice brain is responsible for severe COVID-19

Why are some groups more vulnerable to COVID-19?

Traditional herbal medicine Respiratory Detox Shot (RDS) inhibits SARS-CoV, SARS-CoV-2 and Influenza A infection in vitro

Autoimmune condition biomarkers promote SARS-CoV-2 viral entry, study finds

Neanderthal gene variant increases risk of severe COVID-19

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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