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Using sugar molecules for in vivo tracking of unlabeled stem cells

A Johns Hopkins Medicine scientist who spent 30 years figuring out how to put chemical labels into cells to track their movement in living tissues has found that certain self-renewing stem cells have built-in tracers - made out of sugars - that can do the job without added chemical "labels" when injected into mouse brains.

8 Feb 2022

SARS-CoV-2 cytokine storm inhibited by curcumin nanoparticles

In a recent study published in the journal ACS Applied Bio Materials, researchers demonstrated the inhibitory potential of curcumin-encapsulated polysaccharide nanoparticles (CUR−PS-NPs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein (CoV2-SP)-stimulated cytokine storm in lung and liver epithelial cells.

8 Feb 2022

SARS-CoV-2 Delta variant's effect on COVID-19 vaccine efficacy

In a recent research paper published in the journal Infection, the scientists estimated the transmission and disease severity associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant and the effectiveness of the current coronavirus disease 2019 (COVID-19) vaccines against the same by conducting a literature review. Further, a meta-analysis was conducted to obtain a numeric estimate of the vaccine effectiveness against the Delta variant.

7 Feb 2022

Maternal metabolic syndrome can switch on imprinted gene associated with NAFLD in offspring

New research from North Carolina State University has found that an imprinted gene associated with development of non-alcoholic fatty liver disease (NAFLD) is switched on in mice who nurse from mothers with metabolic syndrome, even when those mice are not biologically related.

7 Feb 2022

Wistar researchers takes a promising step in the direction of developing HIV vaccine

Nearly four decades after its discovery, HIV has killed 36.3 million people, with no vaccine in sight. However, a new study by researchers at The Wistar Institute, an international biomedical research leader in cancer, immunology, infectious disease, and vaccine development, takes a promising step in the direction of developing an HIV vaccine.

4 Feb 2022

'Genetic scissors' can give rise to unforeseen heritable mutations

CRISPR-Cas9, the "genetic scissors", creates new potential for curing diseases; but treatments must be reliable. In a new study, researchers have discovered that the method can give rise to unforeseen changes in DNA that can be inherited by the next generation.

2 Feb 2022

New approach to CAR T-cell therapy for B-cell cancers triples the targeted antigens on cancer cells

Researchers at University Hospitals Seidman Cancer Center and Case Western Reserve University have developed a novel approach to chimeric antigen receptor (CAR) T-cell therapy for B-cell cancers that triples the targeted antigens on cancer cells – a "back up" approach that promises to greatly reduce the potential for antigen escape currently found in CAR T therapies that solely target CD19.

2 Feb 2022

New nanoparticle SARS-CoV-2 vaccine shows stronger, broader, and more durable protection

The first generation of COVID-19 vaccines have been highly effective, but also have limitations: their efficacy can wane without a booster shot, and they may be less effective against some variants.

2 Feb 2022

Nanomedicine can be improved with proper and more predictive in vitro assays

Messenger RNA (mRNA) vaccines are a prime example of the promising field of nanomedicine. But progress in the design and application of nanoparticles as efficient delivery vehicles for biopharmaceutics containing nucleic acid or protein drug substances is, unfortunately, remarkably slow.

1 Feb 2022

Neural stem cells plus HER2 inhibitor drug improve survival in mice with metastatic cancer

Neural stem cells (NSCs) engineered by Northwestern Medicine investigators used in combination with the HER2 inhibitor drug tucatinib improved survival in mice with HER2-positive breast cancer brain metastases, according to findings published in Proceedings of the National Academy of Sciences.

1 Feb 2022

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

In a new study, a team of researchers discovered S-217622, a non-covalent SARS-CoV-2 3C-like protease (3CLpro) inhibitor clinical candidate for the treatment of COVID-19.

31 Jan 2022

Evidence on intra-host recombination of SARS-CoV-2 during superinfection by Alpha and Epsilon variants in USA

A new study captured an instance of SARS-CoV-2 superinfection in an individual, simultaneously infected by two SARS-CoV-2 variants, Alpha and Epsilon during the second COVID-19 wave in New York City in early 2021.

28 Jan 2022

French project takes an extra step in the development of nasal vaccine candidate against COVID-19

The development of a protein vaccine candidate for nasal administration has taken another step. Led by the BioMAP research team, from the Infectiology and Public Health (ISP) joint research unit run by INRAE and the Université de Tours, this project, supported by the Ministry of Higher Education, Research and Innovation, and accompanied by the ANRS | Maladies infectieuses émergentes, is moving up a gear.

27 Jan 2022

Macromolecular gel with therapeutic payload could halt or slow post-traumatic osteoarthritis

Osteoarthritis affects over 32 million Americans, levying a huge cost on society. Unfortunately, other than analgesics, no pharmaceutical therapy exists that can slow or halt disease progression of a major subset of OA: post-traumatic osteoarthritis (PTOA).

26 Jan 2022

in vivo News and Research

Using sugar molecules for in vivo tracking of unlabeled stem cells

SARS-CoV-2 cytokine storm inhibited by curcumin nanoparticles

SARS-CoV-2 Delta variant's effect on COVID-19 vaccine efficacy

Maternal metabolic syndrome can switch on imprinted gene associated with NAFLD in offspring

Wistar researchers takes a promising step in the direction of developing HIV vaccine

'Genetic scissors' can give rise to unforeseen heritable mutations

New approach to CAR T-cell therapy for B-cell cancers triples the targeted antigens on cancer cells

New nanoparticle SARS-CoV-2 vaccine shows stronger, broader, and more durable protection

Nanomedicine can be improved with proper and more predictive in vitro assays

Neural stem cells plus HER2 inhibitor drug improve survival in mice with metastatic cancer

3C-like protease inhibitor clinical candidate, S-217622, as a treatment for SARS-CoV-2

Evidence on intra-host recombination of SARS-CoV-2 during superinfection by Alpha and Epsilon variants in USA

French project takes an extra step in the development of nasal vaccine candidate against COVID-19

Macromolecular gel with therapeutic payload could halt or slow post-traumatic osteoarthritis

Study suggests synthetic SARS-CoV-2 S glycoprotein coated lipid vesicles are an effective vaccine candidate

Gene therapy can provide long-lasting therapeutic benefit in Huntington's disease

Breathing coordinates neuronal activity in the brain regions during sleep

Researchers develop a computational approach to identify genomic safe harbors for therapeutic genes

Human endogenous retrovirus type W envelope protein found to be a biomarker of COVID-19 severity

REM sleep protects animals against predator attacks

eBook: Using iPSCs models for human disease research and drug discovery eBook

Lab Matters host Harriet Gould on building a more connected lab community

The Critical Role of Sample Storage in Drug Discovery and Development

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

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