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Study shows SARS-CoV-2 prompts NLRP3 inflammasome activation through spike-ACE2 receptor interaction

New research assesses the NLR family pyrin domain containing 3 (NLRP3) inflammasome activation in response to SARS-CoV-2 and its spike protein, and the effects of this exposure in the presence of a-synuclein protein aggregate fibrils.

17 Jan 2022

Researchers engineer enucleated cells to deliver therapeutics precisely to diseased tissues

Researchers at University of California San Diego School of Medicine and Moores Cancer Center at UC San Diego Health report successfully removing the nucleus out of a type of ubiquitous cell, known as enucleation, then using the genetically engineered cell as a unique cargo-carrier to deliver therapeutics precisely to diseased tissues.

17 Jan 2022

Monitoring rodents for SARS-CoV-2 and other coronaviruses, Hong Kong

A new study published in the Centers for Disease Control and Prevention’s Emerging Infectious Diseases journal has hypothesized that locations with positive SARS-CoV-2 in sewage could be used as potential surveillance targets to analyze if pestiferous urban rodents shed SARS-CoV-2 into the environment.

16 Jan 2022

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

A new study, published in the journal Cell Chemical Biology, has reported the discovery of acriflavine (ACF), an effective inhibitor of SARS-CoV-2. This drug is a mixture of trypaflavines (3,6-diamino-10-methylacridinium chloride and 3,6-diamino-3-methylacridinium chloride) and proflavine (3,6-diaminoacridine).

16 Jan 2022

Virus-like particles as delivery vehicles for gene-editing

Scientists deliver gene-editing proteins through the use of engineered virus-like particles, which mediated efficient base editing both in vitro and in vivo.

13 Jan 2022

Investigating the presence of human rRNA in the SARS-CoV-2 genome

In a new study, a team of researchers investigated the existence of SARS-CoV-2-host chimeric RNA and described two novel human-derived genomic insertions present in the circulating variants of SARS-CoV-2.

13 Jan 2022

Using lab-grown stomachs to shed light on the symptoms of COVID-19

Could lab-grown 'mini-stomachs' be used to look at COVID-19 symptoms in children? In this interview, we speak to Paolo De Coppi to find out more.

13 Jan 2022

Wearable sweat sensors can help assess an individual's health

Sweating it out through exercise may be a New Year's resolution but it could also help to provide new insights into the state of your health, according to new sensing technology being developed at Simon Fraser University.

12 Jan 2022

Engineering higher affinity SARS-CoV-2 antibodies

A new study describes the potential of engineered neutralizing antibodies that have a high affinity for the binding epitopes.

11 Jan 2022

Novel mechanism linking intercellular adhesion molecule with genetic skin diseases discovered

Northwestern Medicine investigators have discovered a novel mechanism linking an intercellular adhesion molecule with genetic inflammatory skin diseases, according to findings published in the Journal of Clinical Investigation.

11 Jan 2022

Withdrawing steroid treatment found to boost SARS-CoV-2 vaccine-induced immunity in kidney transplant recipients

In a new study, a team of researchers investigated the impact of the fourth dose of a vaccine against COVID-19 in kidney transplant recipients, who had not mounted a humoral immune response to three doses of vaccine.

11 Jan 2022

NeoCura and PhoreMost Announce Research Collaboration to Explore Novel Cancer Therapeutics

NeoCura and PhoreMost today announced an oncology drug discovery research collaboration.

From PhoreMost 11 Jan 2022

SARS-CoV-2 activates microglia in the brain

Researchers demonstrate that SARS-CoV-2 can infect the human microglia.

10 Jan 2022

Neurologist receives ERC grant to study novel light-activated drugs with antiepileptic effects

Dr. Michael Wenzel from the Department of Epileptology at the University Hospital Bonn has received a coveted Starting Grant from the European Research Council.

10 Jan 2022

Isolated antibodies from BNT162b2 vacinee effective against Omicron variant

Researchers screened BNT162b2 COVID-19 vaccine recipients and cloned broadly neutralizing antibodies from an elite vaccinee.

10 Jan 2022

Therapeutic in vivo synthetic chemistry used to make anticancer drugs

An international research group at the RIKEN Cluster for Pioneering Research (CPR) has successfully treated cancer in mice using metal catalysts that assemble anticancer drugs together inside the body.

10 Jan 2022

SARS-CoV-2 shown to spread through cell-to-cell transmission

A new study investigated SARS-CoV-2 cell-to-cell transmission in the context of cell-free infection and compared it to SARS-CoV.

10 Jan 2022

SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

In a new study, researchers used a cell-cell fusion assay to extract potentially cleaved spike protein products from syncytia in order to explore the functional and biochemical characteristics of spike (S) protein when it engages its receptor ACE2 in living cells.

10 Jan 2022

Engineered small extracellular vesicles for the neutralization of SARS-CoV-2

Characterizing these engineered sEVs, the researchers demonstrated that the soluble angiotensin-converting enzyme 2 (sACE-2) loaded sEV successfully binds and thus inhibits the entry of wild-type SARS-CoV-2 as well as its variants, protecting against SARS-CoV-2 infection. They also demonstrated the therapeutic efficacy of these engineered sEVs in vivo.

9 Jan 2022

Study finds novel pathway for understanding why debilitating conditions happen for cancer patients

Severe and persistent disability often undermines the life-saving benefits of cancer treatment. Pain and fatigue - together with sensory, motor, and cognitive disorders - are chief among the constellation of side effects that occur with the platinum-based agents used widely in chemotherapy treatments worldwide.

9 Jan 2022

in vivo News and Research

Study shows SARS-CoV-2 prompts NLRP3 inflammasome activation through spike-ACE2 receptor interaction

Researchers engineer enucleated cells to deliver therapeutics precisely to diseased tissues

Monitoring rodents for SARS-CoV-2 and other coronaviruses, Hong Kong

Topical antiseptic Acriflavine inhibits SARS-CoV-2 and other betacoronaviruses

Virus-like particles as delivery vehicles for gene-editing

Investigating the presence of human rRNA in the SARS-CoV-2 genome

Using lab-grown stomachs to shed light on the symptoms of COVID-19

Wearable sweat sensors can help assess an individual's health

Engineering higher affinity SARS-CoV-2 antibodies

Novel mechanism linking intercellular adhesion molecule with genetic skin diseases discovered

Withdrawing steroid treatment found to boost SARS-CoV-2 vaccine-induced immunity in kidney transplant recipients

NeoCura and PhoreMost Announce Research Collaboration to Explore Novel Cancer Therapeutics

SARS-CoV-2 activates microglia in the brain

Neurologist receives ERC grant to study novel light-activated drugs with antiepileptic effects

Isolated antibodies from BNT162b2 vacinee effective against Omicron variant

Therapeutic in vivo synthetic chemistry used to make anticancer drugs

SARS-CoV-2 shown to spread through cell-to-cell transmission

SARS-CoV-2 spike engagement of ACE2 shown to prime S2′ site cleavage and fusion initiation

Engineered small extracellular vesicles for the neutralization of SARS-CoV-2

Study finds novel pathway for understanding why debilitating conditions happen for cancer patients

eBook: Using iPSCs models for human disease research and drug discovery eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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