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Study into killer T-cell activity could provide roadmap for tackling antibiotic resistance

In a study that could provide a roadmap for combatting the rising threat of drug-resistant pathogens, researchers have discovered the specific mechanism the body's T cells use to kill bacteria.

27 Oct 2017

‘Precision Medicine’ may not always be so precise when applied to diverse populations, study says

Precision Medicine in oncology, where genetic testing is used to determine the best drugs to treat cancer patients, is not always so precise when applied to some of the world's more diverse populations, according to a study led by the Translational Genomics Research Institute, an affiliate of City of Hope, and the Keck School of Medicine of the University of Southern California.

27 Oct 2017

Sleeper cells in cancerous tumors can be destroyed if they possess specific defects

In many metastasized types of cancer, disseminated tumors grow back despite successful chemotherapy. As a research team under the direction of the University of Bern, Switzerland, has now discovered, this is because of isolated cancer cells that survive the chemotherapy due to a phase of dormancy.

27 Oct 2017

New study sheds light on normal function of Parkinson's gene

A new study published in the journal Neuron sheds light on the normal function of LRRK2, the most common genetic cause for late-onset Parkinson's disease. The study was supported by the National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health.

26 Oct 2017

Researchers use machine learning to identify illegal selling of opioids on Twitter

Using advanced machine learning, a cross disciplinary team of University of California San Diego researchers developed technology that mined Twitter to identify entities illegally selling prescription opioids online.

25 Oct 2017

Pre-clinical study reports promising step forward in search for non-addictive painkillers

A pre-clinical study led by Indiana University scientists reports a promising step forward in the search for pain relief methods without the addictive side effects behind the country's current opioid addiction crisis.

25 Oct 2017

Insights from NGLY1 deficiency could provide new approach to treat blood cancers

A new class of drugs for blood cancers such as leukemia and multiple myeloma is showing promise. But it is hobbled by a problem that also plagues other cancer drugs: targeted cells can develop resistance.

25 Oct 2017

Duke Health researchers find anxiety disorders among some problematic marijuana users

About a quarter of adults whose marijuana use is problematic in early adulthood have anxiety disorders in childhood and late adolescence, according to new data from Duke Health researchers.

25 Oct 2017

Study reveals why Alzheimer's drugs fail in clinical trials

A tremendous amount of Amyloid-β peptide (Aβ) (a peptide of ～40 amino acids) accumulates in the brain of Alzheimer's disease patients. γ-Secretase inhibitors were designed to inhibit the enzymatic activity that produces Aβ. By reducing Aβ production, γ-secretase inhibitors were considered able to treat Alzheimer's disease (Aβ hypothesis).

25 Oct 2017

New discovery could speed development and approval of antiviral drugs

New research shows that a new class of antiviral drugs works by causing the virus' replication machinery to pause and backtrack, preventing the virus from efficiently replicating. This discovery, made possible by a high-throughput experimental technique called "magnetic tweezers," could speed the development and approval of related antiviral drugs.

25 Oct 2017

New survey finds huge decline in substance abuse, delinquency among teens

More than a decade of data indicates teens have become far less likely to abuse alcohol, nicotine and illicit drugs, and they also are less likely to engage in delinquent behaviors, such as fighting and stealing, according to results of a national survey analyzed by researchers at Washington University School of Medicine in St. Louis.

25 Oct 2017

Research identifies molecular mechanism that causes kidney cancer to resist drug treatment

New research from The University of Texas Health Science Center at San Antonio and U.S. Department of Veterans Affairs has identified the molecular mechanism that causes kidney cancer to resist drug treatment.

25 Oct 2017

Scientists discover 'molecular pencil sharpener' that releases powerful antibiotics

Picture a brand-new, unsharpened pencil. The graphite at its core can't be used for writing until a pencil sharpener chews away its wooden tip.

24 Oct 2017

Researchers evaluate potential of stem cells, therapeutic agents in neurodegenerative diseases

As the brain has limited capability for self-repair or regeneration, stem cells may represent the best therapeutic approach for counteracting damage to or degeneration of brain tissue caused by injury, aging, or disease.

24 Oct 2017

Increasing the dosage of antidepressants does not carry benefits, analysis reveals

In the current issue of Psychotherapy and Psychosomatics a new analysis discloses that increasing the dosage of antidepressant drugs does not carry benefits. As many patients with unipolar depression do not respond sufficiently to initial antidepressant monotherapy, a dose increase of the current administered antidepressant (dose escalation, high-dose treatment) is frequently carried out as next treatment measure.

24 Oct 2017

New analysis reveals insights into long-term effects of antidepressant drugs

In the current issue of Psychotherapy and Psychosomatics a new analysis discloses insights into the long term effects of antidepressant drugs. Major depressive disorder (MDD) is more often chronic or recurrent in clinical than in community samples.

24 Oct 2017

LSTM researchers find new way to reduce treatment for some parasitic diseases

Researchers from LSTM's Research Centre for Drugs and Diagnostics have found a way of significantly reducing the treatment required for lymphatic filariasis and onchocerciasis from several weeks to seven days. By targeting Wolbachia, a bacterial symbiont that the filarial parasites need to live, the team has discovered a drug synergy that enables effective treatment over a shorter time.

24 Oct 2017

New drug offers hope for treatment of aggressive T-PLL leukemia

Hitherto there has been no adequate treatment available for the rare and highly aggressive malignant blood disease T-PLL leukemia.

24 Oct 2017

Bariatric surgical patients may be vulnerable to opioid dependence

Nearly 9 percent of bariatric surgical patients--or about one in 12--who did not take opioid pain medications until their weight-loss operation, or the month before it, report that they are still using prescription opioids one year postoperatively, according to new research findings.

24 Oct 2017

Nanodiamonds could prevent infection, improve recovery after root canal treatment

People who undergo root canals may soon have a tiny but powerful ally that could prevent infection after treatment.

24 Oct 2017

Drugs News and Research

Study into killer T-cell activity could provide roadmap for tackling antibiotic resistance

‘Precision Medicine’ may not always be so precise when applied to diverse populations, study says

Sleeper cells in cancerous tumors can be destroyed if they possess specific defects

New study sheds light on normal function of Parkinson's gene

Researchers use machine learning to identify illegal selling of opioids on Twitter

Pre-clinical study reports promising step forward in search for non-addictive painkillers

Insights from NGLY1 deficiency could provide new approach to treat blood cancers

Duke Health researchers find anxiety disorders among some problematic marijuana users

Study reveals why Alzheimer's drugs fail in clinical trials

New discovery could speed development and approval of antiviral drugs

New survey finds huge decline in substance abuse, delinquency among teens

Research identifies molecular mechanism that causes kidney cancer to resist drug treatment

Scientists discover 'molecular pencil sharpener' that releases powerful antibiotics

Researchers evaluate potential of stem cells, therapeutic agents in neurodegenerative diseases

Increasing the dosage of antidepressants does not carry benefits, analysis reveals

New analysis reveals insights into long-term effects of antidepressant drugs

LSTM researchers find new way to reduce treatment for some parasitic diseases

New drug offers hope for treatment of aggressive T-PLL leukemia

Bariatric surgical patients may be vulnerable to opioid dependence

Nanodiamonds could prevent infection, improve recovery after root canal treatment

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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