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FDA approves cancer drug Afinitor for treatment of rare genetic disorder

The U.S. Food and Drug Administration approved the cancer drug Afinitor (everolimus) on Friday to treat patients with subependymal giant cell astrocytoma (SEGA) associated with tuberous sclerosis (TS), a rare genetic disorder. This approval was for treatments of SEGA that can not be treated with surgery.

1 Nov 2010

FDA approves Sprycel for treatment of adults with Ph+ CP-CML

The U.S. Food and Drug Administration today approved a new indication for Sprycel (dasatinib) for the treatment of a rare blood cancer when it is first diagnosed. The cancer, called Philadelphia chromosome positive chronic phase chronic myeloid leukemia (Ph+ CP-CML), is a slowly progressing blood and bone marrow disease linked to a genetic abnormality.

29 Oct 2010

Researchers find link between telomere length and colorectal cancer risk

For the first time, researchers have found a link between long telomeres and an increased risk for colorectal cancer, according to research presented at the American Association for Cancer Research special conference on Colorectal Cancer Biology to Therapy, held here Oct. 27-30, 2010.

29 Oct 2010

Reactivating three silenced molecules may provide new strategy to treat multiple myeloma

New research links three molecules to a critical tumor suppressor gene that is often turned off in multiple myeloma, a presently incurable cancer of the blood.

27 Oct 2010

La Jolla Institute scientist wins Malpighi Medal for pioneering work in heart disease

Klaus Ley, M.D, a scientist at the La Jolla Institute for Allergy & Immunology, was recently awarded the prestigious Malpighi Medal at the World Congress for Microcirculation in Paris, France. A lifetime achievement award presented by the European Society for Microcirculation, Dr. Ley received the honor in recognition of his pioneering endeavors in vascular immunology, a scientific discipline that he helped to pioneer, which looks at novel immune-based approaches to combating heart disease. He is only the 17th recipient of the biennial award worldwide.

26 Oct 2010

Study reveals two enzymes help immune cells deploy pathogen-killing traps

A new study reveals that two enzymes help immune cells deploy pathogen-killing traps by unraveling and using the chromatin (DNA and its associated proteins) contained in the cells' nuclei to form defensive webs. The study appears online on October 25 in The Journal of Cell Biology.

26 Oct 2010

BioCryst to present intravenous peramivir data for influenza treatment at IDSA meeting

BioCryst Pharmaceuticals, Inc. announced the presentation of data related to intravenous (i.v.) peramivir for the treatment of influenza at the 48th Annual Infectious Diseases Society of America (IDSA) meeting being held in Vancouver, Canada.

21 Oct 2010

Researchers investigate reverse zoonosis in marine invertebrate

The spread of lethal diseases from animals to humans has long been an issue of great concern to public health officials. But what about diseases that spread in the other direction, from humans to wildlife. A multidisciplinary team of researchers at the University of Georgia has just been awarded a five-year $2 million Ecology of Infectious Diseases grant from the National Science Foundation and National Institutes of Health to study the first known case of such a "reverse zoonosis" that involves the transmission of a human pathogen to a marine invertebrate, elkhorn coral.

21 Oct 2010

New approaches to explore causes of autoimmunity and immune deficiency diseases

A newly identified regulatory process affecting the biology of immune system T cells should give scientists new approaches to explore the causes of autoimmunity and immune deficiency diseases.

20 Oct 2010

SHIP and PTEN enzymes act cooperatively to suppress B cell lymphoma: Study

Lymphoma is a cancer of the immune system. White blood cells divide again and again, spreading abnormally throughout the body. Lymphomas can arise from two types of white blood cells, T cells or B cells, which divide uncontrollably when the molecular mechanisms that keep them in check go awry.

20 Oct 2010

Jefferson researchers progress in understanding mechanism behind systemic fibrotic disorder

Scientists from the Jefferson Institute of Molecular Medicine of Thomas Jefferson University are now several steps closer to understanding the mechanism behind a novel systemic fibrotic disorder that affects some patients with renal insufficiency who receive imaging contrast agents for MRI. Two of their studies on the disorder appear together in the November issue of the Annals of Rheumatic Diseases.

20 Oct 2010

Fluticasone gets rid of eosinophils in the esophagus, but does not improve symptoms

A group of Mayo Clinic researchers conducted the first controlled trial of swallowed fluticasone nasal spray (also known as Flonase) on people with the allergic esophageal condition called eosinophilic esophagitis. Research showed that the aerosolized swallowed allergy drug helped treat the cause of the throat condition, but symptoms lingered. The researchers' findings were presented today at the Annual Scientific Meeting of the American College of Gastroenterology in San Antonio.

18 Oct 2010

New imaging technique to study response of white blood cells to inflammation

Researchers at the University of Calgary Faculty of Medicine are using an innovative new imaging technique to study how white blood cells (called neutrophils) respond to inflammation, and have revealed new targets to inhibit the response.

18 Oct 2010

Research on gut flora may lead to new treatment strategies for atherosclerosis

New findings suggesting that bacteria in the mouth and/or intestine can affect the the outcome pathogenesis of atherosclerosis and lead to new treatment strategies, reveals research from the University of Gothenburg, Sweden.

18 Oct 2010

New development of genetic tool to speed discovery of novel genes involved in cancer

Researchers have developed a genetic tool in mice to speed the discovery of novel genes involved in cancer. The system - called PiggyBac - has already been used by the team to identify novel candidate cancer-causing genes.

15 Oct 2010

Patient-specific experimental vaccine to prevent recurrence of glioblastoma

Mary Lee's primary care physician is also a family friend. When he walked into the exam room in October 2006 with tears in his eyes, she knew something serious was wrong. But she was shocked to learn she had a brain tumor - and later found out it was the most aggressive malignant type, a glioblastoma multiforme.

14 Oct 2010

Scientists unveil quality control mechanism of immune system to destroy pathogens

An Australian team of scientists has uncovered a quality control mechanism that must take place for our immune system to subsequently effectively destroy harmful viruses and bacteria.

14 Oct 2010

ImmunoCellular develops ICT-107 cell-based vaccine for GBM treatment

ImmunoCellular Therapeutics, a biotechnology company focused on the development of novel immune-based cancer therapies, today announced that it has developed an innovative method for manufacturing the company's lead product candidate, ICT-107, a dendritic cell-based vaccine for the treatment of glioblastoma multiforme (GBM).

13 Oct 2010

Researchers investigate mechanism of immune system to decipher gut-dwelling worms

A billion people living in underdeveloped areas around the world are infected with parasitic helminthes, worms that survive by residing in and feeding on their hosts. These infestations can cause chronic intestinal (and occasionally systemic) illnesses leading to long-term disability. Irah King and Markus Mohrs, biomedical researchers at the Trudeau Institute, are investigating illnesses caused by these gut-dwelling worms in an effort to decipher how immune cells send and receive signals that determine the specific immune response to mount.

12 Oct 2010

NIH awards La Jolla Institute $12.6M to develop San Diego's first Center for RNAi screening

The La Jolla Institute for Allergy & Immunology will develop San Diego's first Center for RNAi screening -- a breakthrough genomics technology that will further enhance San Diego's reputation as a national research leader and provide the local biomedical community ready access to the Nobel-Prize winning technology.

11 Oct 2010

Leukocyte News and Research

FDA approves cancer drug Afinitor for treatment of rare genetic disorder

FDA approves Sprycel for treatment of adults with Ph+ CP-CML

Researchers find link between telomere length and colorectal cancer risk

Reactivating three silenced molecules may provide new strategy to treat multiple myeloma

La Jolla Institute scientist wins Malpighi Medal for pioneering work in heart disease

Study reveals two enzymes help immune cells deploy pathogen-killing traps

BioCryst to present intravenous peramivir data for influenza treatment at IDSA meeting

Researchers investigate reverse zoonosis in marine invertebrate

New approaches to explore causes of autoimmunity and immune deficiency diseases

SHIP and PTEN enzymes act cooperatively to suppress B cell lymphoma: Study

Jefferson researchers progress in understanding mechanism behind systemic fibrotic disorder

Fluticasone gets rid of eosinophils in the esophagus, but does not improve symptoms

New imaging technique to study response of white blood cells to inflammation

Research on gut flora may lead to new treatment strategies for atherosclerosis

New development of genetic tool to speed discovery of novel genes involved in cancer

Patient-specific experimental vaccine to prevent recurrence of glioblastoma

Scientists unveil quality control mechanism of immune system to destroy pathogens

ImmunoCellular develops ICT-107 cell-based vaccine for GBM treatment

Researchers investigate mechanism of immune system to decipher gut-dwelling worms

NIH awards La Jolla Institute $12.6M to develop San Diego's first Center for RNAi screening

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