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Prion-like domains in SARS-CoV-2 RBD and ACE2 play important functional roles in viral adhesion and entry

Scientists have recently detected and analyzed viral PrDs in the S protein of SARS-CoV-2, which are the novel regulators of virion assembly.

31 Jan 2022

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

A new paper in the journal Molecules describes this in molecular terms, comparing SARS-CoV-2 with an earlier highly pathogenic coronavirus, SARS-CoV.

31 Jan 2022

Study reveals link between muscular dystrophy and sphingolipids

In a new study, the group of Johan Auwerx at EPFL's School of Life Sciences has made the first connection between muscular dystrophy and sphingolipids, a group of bioactive lipids. The study is published in Science Advances.

29 Jan 2022

Scientists assemble carbon nanotubes in a new way to deliver cancer drugs

Fundamental science often finds applications beyond its original focus. Previously, scientists found applications for small diameter carbon nanotube porins in energy technology.

29 Jan 2022

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

The Damon Runyon Cancer Research Foundation has announced its newest cohort of Damon Runyon Fellows, 13 outstanding postdoctoral scientists conducting basic and translational cancer research in the laboratories of leading senior investigators.

29 Jan 2022

Study demonstrates minimally invasive, aerosolized vaccine candidate to combat SARS-CoV-2

This study showed inhalable Covid-19 mimetic particle carriers as potential, versatile, aerosolizable COVID-19 vaccine candidates if worked on with continued optimization and refinement.

28 Jan 2022

Desipramine and L-cycloserine together reduce ceramide levels in the retina and enhance vision

Researchers from the University of California, Irvine have discovered that the absence of Adiponectin receptor 1 protein (AdipoR1), one of the principal enzymes regulating ceramide homeostasis in the retina, leads to an accumulation of ceramides in the retina, resulting in progressive photoreceptor cell death and ultimately vision loss.

28 Jan 2022

Cedars-Sinai experts conduct a national analysis on COVID-19 lung transplants

The analysis of more than 3,000 lung transplants in the U.S. between Aug. 1, 2020, and Sept. 30, 2021, showed that during the pandemic, 7% of the nation's lung transplants were performed to treat severe, irreversible lung damage caused by COVID-19. More than half of these patients needed ventilators or extracorporeal membrane oxygenation, or ECMO, before their transplant.

27 Jan 2022

Targeting SARS-CoV-2 M protein may help ease severity of COVID-19

A new study, published on the medRxiv preprint server, focused on the production of human CD4+ T cell lines (TCLs), reactive to either S or M protein, and analyzed if the S and M structural proteins had intrinsic differences in driving antigen-specific CD4+ T cell responses.

27 Jan 2022

Study shows enduring T-cell immunity up to at least 1-year after SARS-CoV-2 infection

A new study assesses SARS-CoV-2 antigen-specific cytokine responses in a cohort of SARS-CoV-2 infected individuals with varying levels of disease.

26 Jan 2022

Alterations of sphingolipids and their metabolizing enzymes in hospitalized or convalescent COVID-19 patients

An interdisciplinary team of researchers from Europe analyzed the alterations of sphingolipids and their metabolizing enzymes in hospitalized or convalescent COVID-19 patients.

26 Jan 2022

Endosomal sorting of neuropilin-1 in SARS-CoV-2 infectivity

A study recently identified Neurolipin-1 or NRP1, a host factor for SARS-CoV-2 infection, as a cargo retrograde-transported by the ESCPE-1.

26 Jan 2022

Research says spill-over of SARS-CoV-2 from humans to cattle is possible

In a recent study posted to the bioRxiv* preprint server, a team of researchers assessed the risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) transmission from humans to cattle.

26 Jan 2022

Link established between gut microbiota and chronic inflammatory diseases

An international research team has established a link between gut microbiota and chronic inflammatory diseases such as arthritis.

25 Jan 2022

Spike-mediated CFTR inhibition accounts for airway inflammation in COVID-19

A new study looks at the molecular level inhibition of the protective CFTR gene by the SARS-CoV-2 spike protein.

25 Jan 2022

Evaluation of cross-reactive T cell responses between SARS-CoV-2 and common-cold human coronaviruses

A new study investigated SARS-CoV-2 spike protein responses targeted by cross-reactive T cells that were isolated from convalescent COVID-19 individuals along with previously uninfected donors.

25 Jan 2022

Researchers discover a potential new way to combat antibiotic resistance

Researchers from Monash University have discovered a potential new way to prevent antibiotic resistance and reduce antibiotic intake.

25 Jan 2022

Constructing SARS-CoV-2 virus-like particles in tobacco plants for vaccine development

In a study published in the latest issue of the Scientific Reports, a team of researchers constructed virus-like particles (VLPs) composed of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) membrane (M), envelope (E), and nucleocapsid (N) proteins in tobacco plant using Agrobacterium-mediated delivery.

24 Jan 2022

Novel gene therapy for diseased muscle fiber repair

In this interview, News-Medical speaks to Dr. Jyoti K. Jaiswal about his latest research into gene therapies for limb-girdle muscular dystrophy 2B.

24 Jan 2022

Impact of clustered mutations in SARS-CoV-2 Omicron spike function

In a new study, researchers explored the characteristics of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant of concern (VOC) Omicron BA.1 sublineage clustered mutations.

24 Jan 2022

Membrane News and Research

Prion-like domains in SARS-CoV-2 RBD and ACE2 play important functional roles in viral adhesion and entry

Binding and conformational properties of the SARS-CoV spike protein and hACE2 complex

Study reveals link between muscular dystrophy and sphingolipids

Scientists assemble carbon nanotubes in a new way to deliver cancer drugs

Damon Runyon Cancer Research Foundation announces newest cohort of Fellows and Breakthrough Scientists

Study demonstrates minimally invasive, aerosolized vaccine candidate to combat SARS-CoV-2

Desipramine and L-cycloserine together reduce ceramide levels in the retina and enhance vision

Cedars-Sinai experts conduct a national analysis on COVID-19 lung transplants

Targeting SARS-CoV-2 M protein may help ease severity of COVID-19

Study shows enduring T-cell immunity up to at least 1-year after SARS-CoV-2 infection

Alterations of sphingolipids and their metabolizing enzymes in hospitalized or convalescent COVID-19 patients

Endosomal sorting of neuropilin-1 in SARS-CoV-2 infectivity

Research says spill-over of SARS-CoV-2 from humans to cattle is possible

Link established between gut microbiota and chronic inflammatory diseases

Spike-mediated CFTR inhibition accounts for airway inflammation in COVID-19

Evaluation of cross-reactive T cell responses between SARS-CoV-2 and common-cold human coronaviruses

Researchers discover a potential new way to combat antibiotic resistance

Constructing SARS-CoV-2 virus-like particles in tobacco plants for vaccine development

Novel gene therapy for diseased muscle fiber repair

Impact of clustered mutations in SARS-CoV-2 Omicron spike function

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