Therapy News and Research

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Novel method helps create anticancer nanoclusters without use of additional chemicals

Researchers at Aalto University, Finland, have developed anticancer nanomaterials by simulating the volcano-induced dynamic chemistry of the deep ocean.

12 May 2017

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

ImmusanT, Inc., a clinical-stage company developing Nexvax2, a therapeutic vaccine intended to protect against the effects of gluten exposure while maintaining a gluten-free diet in HLA-DQ2.5+ patients with celiac disease, today announced the publication of positive data from two Phase 1 clinical trials of Nexvax2 in celiac disease.

12 May 2017

New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals

The first drug using spherical nucleic acids to be systemically given to humans has been developed by Northwestern University scientists and approved by the Food and Drug Administration as an investigational new drug for an early-stage clinical trial in the deadly brain cancer glioblastoma multiforme.

12 May 2017

Scientists discover free C3d protein that mitigates tumor-induced immunosuppression

In the body, anti-cancer immunity is immobilized by stealth cancer forces. But a natural de-immobilizer has been identified - and it has a vendetta.

12 May 2017

Immunoreceptor promotes tumor growth in mouse models of liver cancer driven by inflammation

Boosting a part of the immune system known to have anti-tumor properties may actually help tumors grow in cancers linked to chronic inflammation.

12 May 2017

Researchers uncover structural details that make eye-targeting virus a better tool for future therapies

In their quest to replicate themselves, viruses have gotten awfully good at tricking human cells into pumping out viral proteins. That's why scientists have been working to use viruses as forces for good: to deliver useful genes to human cells and help patients who lack important proteins or enzymes.

12 May 2017

Mayo Clinic research advances understanding of DNA repair mechanisms

We humans like to think our DNA is well-protected in the nucleus of each cell. But it's a hard life for the hard-working genetic code.

12 May 2017

Sheffield Teaching Hospitals launches first of its kind laryngeal dystonia clinic in Yorkshire

PATIENTS living with a poorly understood chronic voice disorder which causes involuntary muscle spasms, impairing speech and swallowing, can now receive treatment nearer to home thanks to the launch of a specialist multidisciplinary clinic at Sheffield Teaching Hospitals NHS Foundation Trust.

12 May 2017

Leti's New Deal project could revolutionize IBD therapies for great benefit of patients in the European Union

Leti, a technology research institute of CEA Tech, today announced a European Union project to develop a nanotherapy targeting the molecules involved in inflammatory bowel diseases (IBD), such as Crohn’s disease and ulcerative colitis.

12 May 2017

Scientists use new RNA sequencing and statistical techniques to track stem cells in the nose

Adult stem cells have the ability to transform into many types of cells, but tracing the path individual stem cells follow as they mature and identifying the molecules that trigger these fateful decisions are difficult in a living animal.

12 May 2017

Phase 1 trial shows safety and tolerability of oncolytic HSV-1 for children, young adults with cancer

HSV1716 – an oncolytic herpes simplex virus-1 – has been studied in adults via injection into the brain and superficial tumors.

11 May 2017

Preclinical data reinforces potential efficacy, durability of investigational gene therapy for DMD

Solid Biosciences announced today that new data from two preclinical studies reinforce the potential of its investigational microdystrophin gene therapy, SGT-001, to be an effective treatment approach for Duchenne muscular dystrophy.

11 May 2017

Study reveals how proline metabolism supports breast cancer metastasis

A multinational group of scientists, led by professor Sarah-Maria Fendt, have discovered that breast cancer cells that have invaded other organs rely on a different nutrient metabolism to produce energy than normal cells and non-metastasizing cancer cells.

11 May 2017

CUMC researchers create new organoids that mimic features of full-sized lung

New lung "organoids"-tiny 3-D structures that mimic features of a full-sized lung- have been created from human pluripotent stem cells by researchers at Columbia University Medical Center. The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.

11 May 2017

Scientists produce world's first CT images of biological tissue using protons

An international team of scientists has produced the world's first computerized tomography images of biological tissue using protons - a momentous step towards improving the quality and feasibility of Proton Therapy for cancer sufferers around the world.

11 May 2017

Introduction of ART has increased life expectancy in HIV patients by 10 years

A study published in the journal The Lancet HIV has found an increase in life expectancy of 20-year-old HIV patients in the EU and North America who had started antiretroviral therapy (ART) after it was introduced mid-1990s. When compared with patients who were not treated with ART, the life expectancy had increased by around a decade in these patients.

11 May 2017

Rat study reveals new treatment approach that could potentially prevent osteoarthritis

Maintaining the supply of a molecule that helps to nourish cartilage prevented osteoarthritis in animal models of the disease, according to a report published in Nature Communications online May 11.

11 May 2017

Chemical stimuli by small molecule can improve production of cartilage cells

Cell-based therapies could offer a way to treat cartilage injuries before the ultimate damage of osteoarthritis on articular cartilage.

11 May 2017

Study: Drug-resistant tuberculosis predicted to increase in four high burden countries

Cases of drug-resistant tuberculosis are forecasted to increase in the four high burden countries (India, the Philippines, Russia, and South Africa) between 2000 and 2040, with the upturn likely to be a result of increased transmission of drug-resistant tuberculosis between people, rather than by strains acquiring resistance to anti-tuberculosis drugs, according to a study published in The Lancet Infectious Diseases.

11 May 2017

Sangamo Therapeutics and Pfizer team up for development of Hemophilia A gene therapy

Sangamo Therapeutics, Inc. and Pfizer Inc. today announced an exclusive, global collaboration and license agreement for the development and commercialization of gene therapy programs for Hemophilia A, including SB-525, one of Sangamo's four lead product candidates, which Sangamo expects will enter the clinic this quarter.

11 May 2017

Therapy News and Research

Novel method helps create anticancer nanoclusters without use of additional chemicals

Phase 1 clinical studies reveal safety, tolerability of therapeutic vaccine in celiac disease patients

New spherical nucleic acid drug crosses blood-brain barrier to target brain tumors in animals

Scientists discover free C3d protein that mitigates tumor-induced immunosuppression

Immunoreceptor promotes tumor growth in mouse models of liver cancer driven by inflammation

Researchers uncover structural details that make eye-targeting virus a better tool for future therapies

Mayo Clinic research advances understanding of DNA repair mechanisms

Sheffield Teaching Hospitals launches first of its kind laryngeal dystonia clinic in Yorkshire

Leti's New Deal project could revolutionize IBD therapies for great benefit of patients in the European Union

Scientists use new RNA sequencing and statistical techniques to track stem cells in the nose

Phase 1 trial shows safety and tolerability of oncolytic HSV-1 for children, young adults with cancer

Preclinical data reinforces potential efficacy, durability of investigational gene therapy for DMD

Study reveals how proline metabolism supports breast cancer metastasis

CUMC researchers create new organoids that mimic features of full-sized lung

Scientists produce world's first CT images of biological tissue using protons

Introduction of ART has increased life expectancy in HIV patients by 10 years

Rat study reveals new treatment approach that could potentially prevent osteoarthritis

Chemical stimuli by small molecule can improve production of cartilage cells

Study: Drug-resistant tuberculosis predicted to increase in four high burden countries

Sangamo Therapeutics and Pfizer team up for development of Hemophilia A gene therapy

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

Advancing Intracellular Delivery with LumiPore®

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