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Trial for PTSD treatment with MDMA-assisted psychotherapy receives FDA go-ahead

The United States Food and Drugs Administration FDA has granted permission for phase 3 trials in PTSD (Post traumatic stress disorder) patients using Ecstasy and psychotherapy in a treatment protocol called MDMA-Assisted Psychotherapy PTSD affects thousands of war veterans and other individuals and often leads to fatal outcomes of self-harm and suicides

28 Aug 2017

Long-term use of anti-inflammatory drugs can slow muscle growth in young people

The long-term use of over-the-counter (OTC) anti-inflammatory drugs can inhibit muscle growth in young, healthy individuals engaging in weight training, according to a new study from Karolinska Institutet, reporting on the effects of ibuprofen on the skeletal muscles and published in Acta Physiologica.

28 Aug 2017

Reducing inflammation without lowering cholesterol significantly lowers rate of recurrent cardiovascular events

The researchers from Brigham and Women's Hospital this week have come up with a new study which shows that reducing the inflammation among patients who have already had a heart attack before could prevent the risk of getting more cardiovascular events. The study is published in the latest issue of the New England Journal of Medicine.

28 Aug 2017

FDA issues warning letter to US Stem Cell Clinic for significant deviations

The U.S. Food and Drug Administration today posted a warning letter issued to US Stem Cell Clinic of Sunrise, Florida, and its Chief Scientific Officer Kristin Comella for marketing stem cell products without FDA approval and for significant deviations from current good manufacturing practice requirements, including some that could impact the sterility of their products, putting patients at risk.

28 Aug 2017

Study tests therapeutic effect of conventional and new cancer drug combinations

Cancer is one of the major causes of death worldwide affecting 8.2 million of people per year, and in the US, the number of new cases will achieve 1.6 million in 2017. The global impact of this disease costs a trillion of dollars, which makes critical the development of new drugs and treatment against it.

28 Aug 2017

NSAIDs may not be safe for arthritis patients with cardiovascular risk, study shows

Ibuprofen is associated with increased blood pressure and hypertension compared to celecoxib in patients with osteoarthritis or rheumatoid arthritis and increased risk of cardiovascular disease, according to late-breaking results from the PRECISION-ABPM study presented today in a Hot Line Session at ESC Congress and published in EHJ.

28 Aug 2017

Offshore rush for herpes vaccine roils debate over U.S. safety rules

Defying U.S. safety protections for human trials, an American university and a group of wealthy libertarians, including a prominent Donald Trump supporter, are backing the offshore testing of an experimental herpes vaccine.

28 Aug 2017

Drug reduces inflammation to lower cardiovascular disease and lung cancer risk

The IL-1β inhibitor canakinumab lowers the risk of cardiovascular disease and lung cancer risk by reducing inflammation, according to late-breaking results from the CANTOS trial presented today in a Hot Line - LBT Session at ESC Congress1 and published in the NEJM.

28 Aug 2017

Drug combination improves outcomes in patients with stable coronary or peripheral artery disease

Rivaroxaban plus aspirin improves survival and reduces stroke and heart attack in patients with stable coronary or peripheral artery disease, according to late-breaking results from the COMPASS trial presented today in a Hot Line - LBCT Session at ESC Congress1 and published in the NEJM.

28 Aug 2017

Studies reveal strategies for using shingles vaccine in arthritis patients

New research indicates that the live varicella-zoster vaccine--which is given to protect against shingles--elicits robust immune responses in patients when administered several weeks prior to the start of treatment with the arthritis drug tofacitinib.

28 Aug 2017

Drug combination superior in preventing further heart complications in people with vascular disease

A major international study has found that the combination of two drugs - rivaroxaban and aspirin -- is superior to aspirin alone in preventing further heart complications in people with vascular disease.

28 Aug 2017

Biomedical engineering researchers aim to attack two banes of cardiovascular disease

Biomedical engineering researchers will attack two banes of cardiovascular disease - heart failure after heart attacks and the scourge of resistant high blood pressure - with $4.8 million in National Institutes of Health grants that begin this fall.

26 Aug 2017

SLU-led project receives NIH funding for clinical trial on potential treatment for MDR-TB

Saint Louis University is leading a multi-national clinical trial of what could become a regimen for drug resistant tuberculosis (TB) that does not require injectable medications. The project is funded by a $6.4 million task order from the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health.

26 Aug 2017

UC San Diego researchers receive $18.2 million grant for B cell cancer clinical trial

The Independent Citizens Oversight Committee of the California Institute for Regenerative Medicine today unanimously approved an $18.29 million grant to University of California San Diego School of Medicine researchers to fund a phase Ib/IIa clinical trial of a novel combination drug therapy for B-cell cancers.

26 Aug 2017

ESC recommendations on management of patients with peripheral arterial diseases published

European Society of Cardiology Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, developed in collaboration with the European Society for Vascular Surgery (ESVS), are published online today in European Heart Journal, European Journal of Vascular and Endovascular Surgery, and the ESC website.

26 Aug 2017

Collaborative project reaches milestone halfway point in constructing Kinase Chemogenomic Set

The Structural Genomics Consortium at the University of North Carolina at Chapel Hill (SGC-UNC), in partnership with the DiscoverX Corporation, has reached the milestone halfway point in its development of the Kinase Chemogenomic Set, a potent group of inhibitors which allow deeper exploration of the human kinome, a family of enzymes critical to understanding human disease and developing new therapies.

26 Aug 2017

Research paves way for new drugs that may prevent tumor repopulation after radiation therapy

Whenever an organism is damaged, the cells surrounding the wound receive signals to proliferate more intensely so as to regenerate the injured tissue.

26 Aug 2017

Researchers use zebrafish animal model to explore drug-seeking behavior

As the opioid crisis escalates, the science behind addiction remains poorly understood. To address this need, researchers at University of Utah Health devised a system that allowed zebrafish, a small tropical fish, to self-administer doses of hydrocodone, an opioid commonly prescribed to people for pain.

26 Aug 2017

New review explores evolving treatments and future therapies for osteoarthritis pain

A new review by David A. Walsh and Joanne Stocks in the September 2017 issue of SLAS Discovery (formerly the Journal of Biomolecular Screening) explores evolving treatments and future therapies for osteoarthritis (OA) pain.

26 Aug 2017

ACR applauds legislative and regulatory initiatives to expedite approval of new biosimilar therapies

"Expanding our patients' access to safe, effective, and affordable biologic and biosimilar therapies is a top priority of the rheumatology community.

26 Aug 2017

Drugs News and Research

Trial for PTSD treatment with MDMA-assisted psychotherapy receives FDA go-ahead

Long-term use of anti-inflammatory drugs can slow muscle growth in young people

Reducing inflammation without lowering cholesterol significantly lowers rate of recurrent cardiovascular events

FDA issues warning letter to US Stem Cell Clinic for significant deviations

Study tests therapeutic effect of conventional and new cancer drug combinations

NSAIDs may not be safe for arthritis patients with cardiovascular risk, study shows

Offshore rush for herpes vaccine roils debate over U.S. safety rules

Drug reduces inflammation to lower cardiovascular disease and lung cancer risk

Drug combination improves outcomes in patients with stable coronary or peripheral artery disease

Studies reveal strategies for using shingles vaccine in arthritis patients

Drug combination superior in preventing further heart complications in people with vascular disease

Biomedical engineering researchers aim to attack two banes of cardiovascular disease

SLU-led project receives NIH funding for clinical trial on potential treatment for MDR-TB

UC San Diego researchers receive $18.2 million grant for B cell cancer clinical trial

ESC recommendations on management of patients with peripheral arterial diseases published

Collaborative project reaches milestone halfway point in constructing Kinase Chemogenomic Set

Research paves way for new drugs that may prevent tumor repopulation after radiation therapy

Researchers use zebrafish animal model to explore drug-seeking behavior

New review explores evolving treatments and future therapies for osteoarthritis pain

ACR applauds legislative and regulatory initiatives to expedite approval of new biosimilar therapies

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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