Preclinical News and Research

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How gut microbiota control feelings of fullness after eating

A recent study discusses recent findings linking satiety to the gut microbiome.

7 Mar 2023

Study reveals the LDLR pathway as a ubiquitous metabolic vulnerability in high grade gliomas

New research has shown that the blood vessels that feed aggressive brain tumors have receptors that could allow a new type of drug-containing nanoparticle to be used to starve the tumors of the energy they use to grow and spread, and also cause other disruptions to their adapted existence, even killing themselves.

7 Mar 2023

Tumors' response to hormone therapy may be a biomarker for personalization of breast radiotherapy

How estrogen receptor-positive (ER+) breast cancer responds to hormone therapy may hold keys to understanding how it will respond to radiation therapy, and an experimental drug that increases the effectiveness of hormone therapy also overcomes radiation resistance in breast cancer, a study by UT Southwestern Medical Center researchers shows.

6 Mar 2023

Evaluating how bacterial therapeutics may synergize with existing anti-cancer therapies

It may come as a surprise, but bacteria love to grow inside tumors. It's the environment - tumors are typically acidic, have low amounts of oxygen, and are filled with dead cells, which all facilitate bacterial growth.

6 Mar 2023

Gene mutation capable of regulating pain discovered

Pain afflicts at least 1.5 billion people worldwide, and despite the availability of various painkilling drugs, not all forms of pain are treatable.

3 Mar 2023

Age-associated B cells found to be important drivers of lupus

A group of University of Pittsburgh researchers has given new meaning to "knowing your ABCs."

3 Mar 2023

Immunomodulatory effects of biotics-supplemented infant formulas

A review article published in the journal Nutrients describes the effects and benefits of pre-, pro-, syn-, and postbiotics-containing infant formulas in terms of modulating gut microbiota, immune response, and allergy susceptibility of newborns and infants.

1 Mar 2023

Researchers receive $15 million to study the brain processes involved in speech, epilepsy, and reading

Three grants totaling $15 million, which aim to enhance knowledge of the brain processes that play a key role in speech, epilepsy, and reading, have been awarded to researchers at UTHealth Houston by the National Institutes of Health Brain Research Through Advancing Neurotechnologies (BRAIN) Initiative.

1 Mar 2023

Product development and drug delivery at Seda

In this interview, NewsMedical speaks with Shanoo about her career progression and role in Seda Pharmaceutical regarding product development and drug delivery. She also outlines some of the services that Seda offers.

From Seda Pharmaceutical Development Services 1 Mar 2023

New funding to accelerate development of potential anti-cancer compound into the clinic

For the past few decades, Dr. Iwao Ojima has been working in his Stony Brook University Department of Chemistry Laboratory and through the Institute of Chemical Biology & Drug Discovery (ICB&DD) to develop next-generation anti-cancer agents.

28 Feb 2023

CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System

CN Bio, a leading Organ-on-a-Chip (OOC) company that designs and manufactures single-and multi-organ microphysiological systems (MPS), today announced the commercial launch of the PhysioMimix™ Single-organ Higher Throughput (HT) System.

From CN Bio 28 Feb 2023

The natural history of tau accumulation and the impact of disease stage and reference region on the magnitude and effect size of regional change

Researchers performed serial tau imaging with 18F-MK6240 to detect tau accumulation in cognitively unimpaired beta-amyloid negative Alzheimer’s disease patients as well as those with mild cognitive impairment who were Aβ+ at baseline.

27 Feb 2023

Preclinical News and Research

How gut microbiota control feelings of fullness after eating

Study reveals the LDLR pathway as a ubiquitous metabolic vulnerability in high grade gliomas

Tumors' response to hormone therapy may be a biomarker for personalization of breast radiotherapy

Evaluating how bacterial therapeutics may synergize with existing anti-cancer therapies

Gene mutation capable of regulating pain discovered

Age-associated B cells found to be important drivers of lupus

Immunomodulatory effects of biotics-supplemented infant formulas

Researchers receive $15 million to study the brain processes involved in speech, epilepsy, and reading

Product development and drug delivery at Seda

New funding to accelerate development of potential anti-cancer compound into the clinic

CN Bio extends microphysiological system portfolio with PhysioMimix Single-Organ Higher Throughput System

The natural history of tau accumulation and the impact of disease stage and reference region on the magnitude and effect size of regional change

Study establishes new pre-clinical model to develop clinically relevant treatments for heart attacks

Effects of nanoparticles on gouty arthritis in animal models of gout

First phase I trial of intravenous mistletoe extract to treat advanced cancer

Step-by-step process of rewiring cells to generate germ cell precursors

Two new zebrafish models for studying the most common cause of Leigh syndrome developed

Life Sciences Innovator Category Winner 2023

EIT-based imaging technology for non-invasive anisotropic transmembrane transport of cell-spheroid

Researchers provide a framework for unifying and categorizing neurodegenerative diseases based on eight hallmarks

Event guide: 4th LNP Formulation & Process Development Summit eBook

Latest eBooks

Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

Advancing degrader and proximity-based drug development

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics