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Existing drug shows promise for treating common liver disease

The University of Barcelona has led a study that suggests using the drug known as pemafibrate to treat liver disease associated with metabolic disorders, the most common liver pathology in the world, which affects one in four people. The drug has long been marketed in Japan for another use: improving blood lipid levels in patients with hyperlipidaemia, a common condition in diabetics. Now, however, it could help address this serious liver disease, which still has no specific treatment.

11 Jul 2024

Scientists discover a molecular defect that promotes pathologic immune response in lupus

Northwestern Medicine and Brigham and Women's Hospital scientists have discovered a molecular defect that promotes the pathologic immune response in systemic lupus erythematosus (known as lupus) and show that reversing this defect may potentially reverse the disease.

10 Jul 2024

Repurposing pemafibrate to treat liver disease associated with metabolic disorders

10 Jul 2024

Tirzepatide outperforms semaglutide in weight loss for overweight and obese adults

Tirzepatide leads to significantly greater weight loss than semaglutide in overweight or obese adults, with no significant difference in gastrointestinal adverse effects.

10 Jul 2024

Bovine H5N1 flu virus in cow milk poses significant health risks, study shows

Study characterizes the pathogenicity and transmission dynamics of the H5N1 influenza virus in bovine milk, highlighting significant public health risks and potential mammalian transmission.

10 Jul 2024

Fungal endophytes: A promising frontier for breast cancer treatment

A recent study in Heliyon highlights the potential of fungal endophytes in developing novel anti-cancer agents, specifically targeting breast cancer therapy.

10 Jul 2024

Transforming growth factor beta inhibition boosts NK cell therapy against hepatocellular carcinoma

Researchers at University of California San Diego have found that the most common form of liver cancer - one with a high mortality rate - can be better targeted and treated using an innovative new stem cell-derived therapy, according to a recently published study in Cell Stem Cell.

9 Jul 2024

COVID-19 and metallic taste: Study connects immunoglobulin levels to sensory impairment

Researchers investigated whether COVID-19-related sensory deficiencies are associated with transcriptome changes in the foliate papillae area of the tongue.

9 Jul 2024

Combined use of popular diabetes drugs likely to offer additional protection against heart and kidney disease

New research shows combined use of sodium glucose co-transporter 2 inhibitors (SGLT2is) and glucagon-like peptide-1 receptor agonists (GLP1-RAs) is likely to offer additional protection against heart and kidney disease in patients with diabetes.

8 Jul 2024

Semaglutide linked to increased risk of severe eye condition NAION in new study

Research shows semaglutide users face a significantly higher risk of developing non-arteritic anterior ischemic optic neuropathy (NAION) compared to users of other medications for diabetes and obesity.

8 Jul 2024

How does SARS-CoV-2 cause lymphopenia when T cells barely express ACE-2 receptors?

Researchers reveal both direct and indirect mechanisms of SARS-CoV-2-induced lymphopenia, highlighting the role of CD147 and alternative viral entry routes into T cells.

8 Jul 2024

GLP-1 drugs found to lower cancer risk in diabetes patients

Research finds that GLP-1 receptor agonists significantly reduce the risk of 10 out of 13 obesity-associated cancers in type 2 diabetes patients compared to insulins, but show varied results against metformin.

8 Jul 2024

Semaglutide and very-low calorie diet combo shows superior results in managing type 2 diabetes

A study from the University of Nottingham shows that combining Semaglutide with a very-low calorie diet significantly improves weight loss and glycemic control in type 2 diabetes patients.

8 Jul 2024

Telehealth reduces stigma and barriers for addiction treatment, study finds

Even as the nation's opioid epidemic continues to ravage families and communities nationwide - with more than 100,000 Americans dying of drug overdoses each year - stigma remains a barrier for many people accessing treatment for addiction.

8 Jul 2024

Plant-derived substance shows promise against pulmonary hypertension

A substance derived from the plant Ardisia crenata works in a different way than existing drugs. And in doing so, it is highly effective.

8 Jul 2024

Breakthrough humanized mouse model offers new insights for immunotherapy development

A breakthrough for biomedical research promises new insight into immunotherapy development and disease modeling.

5 Jul 2024

Innovative research sheds light on migraine mechanisms and potential therapies

New research describes for the first time how a spreading wave of disruption and the flow of fluid in the brain triggers headaches, detailing the connection between the neurological symptoms associated with aura and the migraine that follows.

4 Jul 2024

Innovative study on gut bacteria and T cells wins NOSTER & Science Microbiome Prize

In the gut, dozens of strains of bacteria exert different effects on the immune system that in turn impact our health – fending off pathogens, helping digest food and maybe even influencing behavior. But pinpointing which bacteria exert which effects has been challenging.

4 Jul 2024

Stanford researchers uncover key to overcoming chemoresistance in pancreatic cancer

Pancreatic cancer is a particularly aggressive and difficult-to-treat cancer, in part because it is often resistant to chemotherapy.

4 Jul 2024

Novel compound amplifies naloxone's power to reverse overdoses

In a Stanford Medicine-led study, researchers combed through billions of compounds to find one that could enhance naloxone’s ability to fend off more potent opioids, with promising results in mice.

4 Jul 2024

Receptor News and Research

Existing drug shows promise for treating common liver disease

Scientists discover a molecular defect that promotes pathologic immune response in lupus

Repurposing pemafibrate to treat liver disease associated with metabolic disorders

Tirzepatide outperforms semaglutide in weight loss for overweight and obese adults

Bovine H5N1 flu virus in cow milk poses significant health risks, study shows

Fungal endophytes: A promising frontier for breast cancer treatment

Transforming growth factor beta inhibition boosts NK cell therapy against hepatocellular carcinoma

COVID-19 and metallic taste: Study connects immunoglobulin levels to sensory impairment

Combined use of popular diabetes drugs likely to offer additional protection against heart and kidney disease

Semaglutide linked to increased risk of severe eye condition NAION in new study

How does SARS-CoV-2 cause lymphopenia when T cells barely express ACE-2 receptors?

GLP-1 drugs found to lower cancer risk in diabetes patients

Semaglutide and very-low calorie diet combo shows superior results in managing type 2 diabetes

Telehealth reduces stigma and barriers for addiction treatment, study finds

Plant-derived substance shows promise against pulmonary hypertension

Breakthrough humanized mouse model offers new insights for immunotherapy development

Innovative research sheds light on migraine mechanisms and potential therapies

Innovative study on gut bacteria and T cells wins NOSTER & Science Microbiome Prize

Stanford researchers uncover key to overcoming chemoresistance in pancreatic cancer

Novel compound amplifies naloxone's power to reverse overdoses

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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