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Researchers identify MLC1 as potential target in multiple sclerosis

Researchers identify MLC1 as potential target in multiple sclerosis

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system caused by the immune system. B cells, which are a type of white blood cell, play a role in the development of MS and are thus a target for therapies.

18 Feb 2025

Human-specific gene variant may hold key to evolution of language

Human-specific gene variant may hold key to evolution of language

The origins of human language remain mysterious. Are we the only animals truly capable of complex speech? Are Homo sapiens the only hominids who could give detailed directions to a far-off freshwater source or describe the nuanced purples and reds of a dramatic sunset?

18 Feb 2025

Strengthening the gut barrier may halt Crohn’s disease progression

Strengthening the gut barrier may halt Crohn’s disease progression

Researchers at the University of Gothenburg, Sweden, have uncovered a critical mechanism that may pave the way for innovative treatments for Crohn's disease.

18 Feb 2025

ImmuneLENS method provides new insights into cancer prognosis

ImmuneLENS method provides new insights into cancer prognosis

The immune systems of cancer patients are highly disrupted, with those who have a higher number of immune cells in their blood having a better survival rate, finds a new study that uses a pioneering technique developed by researchers at UCL and the Francis Crick Institute.

18 Feb 2025

Gene therapy breakthrough offers hope for severe Dravet syndrome cases

Gene therapy breakthrough offers hope for severe Dravet syndrome cases

AAV-Navβ1 gene therapy effectively reduces seizures and prolongs life in a mouse model of SCN1B-linked Dravet syndrome, paving the way for future treatments.

18 Feb 2025

Scientists pinpoint metabolic failure as the cause of muscle loss in aging

Scientists pinpoint metabolic failure as the cause of muscle loss in aging

A multi-omics study reveals that impaired branched-chain amino acid (BCAA) catabolism is a key driver of sarcopenia, suggesting it as a potential therapeutic target.

17 Feb 2025

Cancer-free for 18 years: CAR-T therapy sets new milestone in neuroblastoma treatment

Cancer-free for 18 years: CAR-T therapy sets new milestone in neuroblastoma treatment

A groundbreaking study in Nature Medicine reveals that GD2 CAR-T cell therapy can lead to long-term remission in children with neuroblastoma, with one patient remaining cancer-free for over 18 years.

17 Feb 2025

Do probiotics enhance sports performance?

Do probiotics enhance sports performance?

Researchers found that probiotics may enhance endurance, recovery, and immune function in athletes, but the evidence for strength and power performance remains limited.

17 Feb 2025

Sweat fails to match blood in tracking inflammation after heart attacks

Sweat fails to match blood in tracking inflammation after heart attacks

Researchers found that while sweat biomarkers remain stable, plasma biomarkers show significant inflammatory changes after a heart attack, highlighting the limitations of sweat analysis for tracking recovery.

17 Feb 2025

Peristaltic pumping motion found to trigger amyloid formation

Peristaltic pumping motion found to trigger amyloid formation

Researchers from Osaka University find that peristaltic pump action and high shear flow forces promote amyloid nucleation.

17 Feb 2025

AI predicts preterm birth risk with 82% accuracy

AI predicts preterm birth risk with 82% accuracy

Researchers used machine learning models to predict preterm birth risk, identifying linear SVMs as the most accurate, with key predictors including inflammation and blood composition markers.

17 Feb 2025

Rare enterovirus strain in Spain raises alarms over potential outbreaks

Rare enterovirus strain in Spain raises alarms over potential outbreaks

Scientists in Spain detected Enterovirus C105 (EV-C105), a rare virus linked to respiratory and possible neurological illness in children, highlighting the emergence of a genetically distinct viral strain.

17 Feb 2025

Lecanemab and donanemab slow Alzheimer’s decline, but is the benefit worth the cost?

Lecanemab and donanemab slow Alzheimer’s decline, but is the benefit worth the cost?

Study finds that disease-modifying therapies for Alzheimer’s, lecanemab and donanemab, can extend independence in daily activities by up to 13 months, though their clinical relevance remains debated.

17 Feb 2025

Study links sucrase defects to increased IBS risk and severe symptoms

Study links sucrase defects to increased IBS risk and severe symptoms

Sucrase-isomaltase (SI) is an intestinal enzyme critical for the digestion of dietary carbohydrates, particularly sucrose and starch.

17 Feb 2025

Breakthrough computational tool enhances design of targeted antiviral therapies

Breakthrough computational tool enhances design of targeted antiviral therapies

Viruses, like those that cause COVID-19 or HIV, are formidable opponents once they invade our bodies. Antiviral treatments strive to block a virus or halt its replication.

17 Feb 2025

Diabetes drugs may boost brain health but experts warn of risks

Diabetes drugs may boost brain health but experts warn of risks

Researchers reviewed 374 studies to explore how GLP-1RAs, originally for diabetes, may impact brain health, finding potential benefits for dementia and addiction but inconsistent results for mood disorders.

16 Feb 2025

Novel method for generating antibodies could revolutionize Alzheimer's and Parkinson's research

Novel method for generating antibodies could revolutionize Alzheimer's and Parkinson's research

In diseases like Parkinson's and Alzheimer's, specific proteins misfold and clump together, forming toxic aggregates that damage brain cells.

16 Feb 2025

Gene therapy shows promise in treating SCN1B-linked epileptic encephalopathies

Gene therapy shows promise in treating SCN1B-linked epileptic encephalopathies

Dravet syndrome and other developmental epileptic encephalopathies are rare but devastating conditions that cause a host of symptoms in children, including seizures, intellectual disability, and even sudden death.

14 Feb 2025

Study reveals key role of opsin 3 in regulating food intake and energy balance

Study reveals key role of opsin 3 in regulating food intake and energy balance

Scientists discovered years ago that the hypothalamus - which helps to manage body temperature, hunger, sex drive, sleep and more - includes neurons that express the protein opsin 3 (OPN3).

14 Feb 2025

Intracranial hemorrhages linked to higher dementia risk

Intracranial hemorrhages linked to higher dementia risk

Weill Cornell Medicine researchers have found that intracranial hemorrhages, or "brain bleeds" caused by a ruptured blood vessel in the brain, double a person's risk of developing dementia later in life.

14 Feb 2025

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