Immune System News and Research

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TLR4 may provide new strategy for treating patients with PDAC: Study

Pancreatic ductal adenocarcinoma is a highly malignant digestive tumor with a very poor prognosis. Hypoxia-inducible transcription factor-1α is involved in malignant progression in many solid tumors, including PDAC, upregulation of HIF-1α accelerates PDAC progression, but the exact regulatory mechanisms of HIF-1αin PDAC has not been unequivocally addressed.

28 Jun 2010

Scientists discover characteristic amyloid plaques in retinas from Alzheimer's disease patients

The nerve cell-damaging plaque that builds up in the brain with Alzheimer's disease also builds up in the retinas of the eyes - and it shows up there earlier, leading to the prospect that noninvasive optical imaging of the eyes could lead to earlier diagnosis, intervention and monitoring of the disease, according to new research.

25 Jun 2010

Researchers uncover association between free radical-mediated reactions and progression of SLE

University of Texas Medical Branch researchers have uncovered an association between free radical-mediated reactions and the severity and progression of system lupus erythematosus. Higher levels of oxidative and nitrosative stress markers were found in SLE patients with greater disease activity suggesting a causal relationship. Full findings of the study are available in the July issue of Arthritis & Rheumatism, a journal published by Wiley-Blackwell on behalf of the American College of Rheumatology.

25 Jun 2010

IDRI signs Research Collaboration Agreement with PATH

Two global health non-profit organizations headquartered in Seattle, Washington, the Infectious Disease Research Institute and PATH, have entered into a Research Collaboration Agreement to evaluate novel adjuvants for their ability to enhance the immune response of pandemic influenza vaccines in development. The collaboration supports the goal of PATH's influenza vaccine project to advance the development of promising new influenza vaccines focusing on novel technologies that can be accessible, affordable, and available to people in low-resource countries in a global outbreak.

25 Jun 2010

Scientists report first preliminary description of bed bug's sialome

With bed bugs reemerging as a nuisance in some parts of the country, scientists are reporting the first preliminary description of the bug's sialome - the saliva proteins that are the secret to Cimex lectularius' ability to suck blood from its human victims and escape to bite again with risking a lethal slap. The findings, which could have medical applications in diagnosing bed bug bites and preventing the itch, appear in ACS' monthly Journal of Proteome Research.

25 Jun 2010

New research suggests resveratrol may inhibit pathogenic blood vessel formation

Current research suggests that resveratrol, a naturally occurring compound found in red wine, grapes, blueberries, peanuts, and other plants, inhibits pathogenic new blood vessel growth.

25 Jun 2010

Editors of Canadian Medical Association Journal warn polio outbreak in Tajikistan could spread

"A large polio outbreak in Tajikistan - Europe's first in years - has the potential to further spread the dangerous virus to other regions of the world, the [editors of] the Canadian Medical Association Journal [CMAJ] warned Wednesday" in an editorial appearing in the journal, the Canadian Press reports.

25 Jun 2010

Gene therapy holds promise in treating cancer, cardiovascular and neurodegenerative diseases

EUREKA project E! 3371 Gene Transfer Agents has made great advances in the development of novel non-viral carriers able to introduce genetic material into the target cells.

25 Jun 2010

June issue of Clinic Women's HealthSource provides overview of anemia

Anemia is not a normal part of aging, yet it's fairly common in older adults and causes frailness, weakness and increased risk of falls. According to Mayo Clinic Women's HealthSource, more than one in 10 older adults has anemia. Twenty percent of women are anemic by age 85.

24 Jun 2010

UCSD researchers awarded $2.5M CIRM grant to explore stem cells

A pair of University of California San Diego researchers - Martin Marsala, a specialist in spinal cord trauma and disorders, and Yang Xu, an immunologist - have been awarded more than $2.5 million in new grants from the California Institute for Regenerative Medicine.

24 Jun 2010

Treatment options for patients with MS

The best one-word description for multiple sclerosis is "unpredictable," according to the June issue of Mayo Clinic Women's HealthSource. MS interferes with the communication between the brain and the rest of the body. Just how that interference plays out in symptoms is different for everyone -- thus, the unpredictable label.

24 Jun 2010

Cedars-Sinai researchers awarded $1.47M grant to study stem cell immune rejection response

A team of Cedars-Sinai Regenerative Medicine Institute researchers led by Terrence Town, Ph.D. has been awarded a three-year, $1.47 million grant from the California Institute for Regenerative Medicine to fund research into mechanisms for how human immune systems reject or accept transplanted brain stem cells.

24 Jun 2010

Female biology screens for the best sperm: Study

A new study has revealed that the female reproductive system is ‘choosy’ when it comes to inferior quality sperm and rejects the ‘advances’ of spermatozoa that are not good enough to create a pregnancy.

23 Jun 2010

University of Colorado honors Taligen as Bioscience Company of the Year

Taligen Therapeutics, a biotechnology company developing therapies that regulate the complement system to treat inflammatory and immune diseases, today announced that it has been selected as the Bioscience Company of the Year by the University of Colorado with its 7th Annual Technology Transfer Awards in recognition of its leadership position in developing a pipeline of novel protein therapeutics that modulate the complement system to treat a wide range of inflammatory diseases.

23 Jun 2010

Shift in balance between good and bad bacteria in gut could be a harbinger of colon cancer: Study

The human body contains more bacteria than it does cells. These bacterial communities can have a positive effect on our health, by training our immune systems and helping to metabolize the foods we eat. But they can also set us up to develop digestive disorders, skin diseases, and obesity.

23 Jun 2010

Spanish scientists propose human amniotic membrane as new tool for repairing damaged articular cartilage

Spanish scientists have proposed using human amniotic membrane as a new tool for repairing damaged human articular cartilage, which heals very poorly because of its low capacity for self-repair. Their research, published in the journal Cell and Tissue Banking, shows that the cellular density of the cartilage synthesised could be greater than that of the body's own natural cartilage.

23 Jun 2010

Student receives two-year $46,000 fellowship to research on a parasite that causes Chagas' disease

Michelle Oppenheimer of Charlotte, N.C., a Ph.D. student in biochemistry in the College of Agriculture and Life Sciences at Virginia Tech, has received a two-year $46,000 fellowship from the American Heart Association to advance her research on a parasite that causes Chagas' disease, which can lead to swelling and inflammation of the heart.

23 Jun 2010

UAB receives $1.47M NHLBI grant to study red blood cell lesion

Researchers in the University of Alabama at Birmingham (UAB) departments of Pathology, Microbiology and Surgery have received a $1.47 million grant from the National Heart, Lung, and Blood Institute (NHLBI) to study so-called red blood cell lesion, a term given to the potentially harmful changes in red blood cells that have been stored for longer times after collection.

23 Jun 2010

Researchers identify promising gene therapy for DMD

CureDuchenne, the Orange County non-profit focused on finding a cure for Duchenne muscular dystrophy (DMD) is one step closer to that goal through the work of Dr. Jeff Chamberlain.

23 Jun 2010

IMUC signs exclusive licensing agreement with Targepeutics for acquisition of IL-13Ra2 receptor

ImmunoCellular Therapeutics, a clinical-stage biotechnology company focused on developing new immune-based products to treat cancer, today announced it has entered into an exclusive licensing agreement with Targepeutics, Inc. for ImmunoCellular's acquisition of Targepeutics' worldwide intellectual property rights surrounding the IL-13 receptor, alpha 2.

23 Jun 2010

Immune System News and Research

TLR4 may provide new strategy for treating patients with PDAC: Study

Scientists discover characteristic amyloid plaques in retinas from Alzheimer's disease patients

Researchers uncover association between free radical-mediated reactions and progression of SLE

IDRI signs Research Collaboration Agreement with PATH

Scientists report first preliminary description of bed bug's sialome

New research suggests resveratrol may inhibit pathogenic blood vessel formation

Editors of Canadian Medical Association Journal warn polio outbreak in Tajikistan could spread

Gene therapy holds promise in treating cancer, cardiovascular and neurodegenerative diseases

June issue of Clinic Women's HealthSource provides overview of anemia

UCSD researchers awarded $2.5M CIRM grant to explore stem cells

Treatment options for patients with MS

Cedars-Sinai researchers awarded $1.47M grant to study stem cell immune rejection response

Female biology screens for the best sperm: Study

University of Colorado honors Taligen as Bioscience Company of the Year

Shift in balance between good and bad bacteria in gut could be a harbinger of colon cancer: Study

Spanish scientists propose human amniotic membrane as new tool for repairing damaged articular cartilage

Student receives two-year $46,000 fellowship to research on a parasite that causes Chagas' disease

UAB receives $1.47M NHLBI grant to study red blood cell lesion

Researchers identify promising gene therapy for DMD

IMUC signs exclusive licensing agreement with Targepeutics for acquisition of IL-13Ra2 receptor

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