Clinical Trial News and Research

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New dual-chamber wireless pacemaker shows reliable performance in clinical trial

A dual-chamber wireless pacemaker provides reliable performance over three months, bolstering evidence for this new pacemaker option, according to results from a multi-center, international clinical trial co-led by a Weill Cornell Medicine and NewYork-Presbyterian investigator.

30 Jul 2024

Study reveals curcumin’s antidepressant effects in obese type 2 diabetes patients

A randomized clinical trial (RCT) to investigate the effectiveness of curcumin in lowering depression among obese individuals with diabetes mellitus type 2 (T2DM).

30 Jul 2024

Genetic variants associated with Parkinson's more common than estimated

New research has found that genetic variants associated with Parkinson's disease (PD) are more common than researchers previously believed. Investigators in the Parkinson's Foundation-backed PD GENEration study – which reached its goal of 15,000 participants ahead of schedule this spring – found that 13% of participants have a genetic form of PD, which is a significant observation compared to long-standing estimates. Results from the first 3.5 years of the study, which examined a broad North American cohort, were published in the peer-reviewed scientific journal Brain.

30 Jul 2024

Hospital-based addiction consult services show promise in improving opioid use disorder treatment uptake

Previous research has found that over 80 percent of people with opioid use disorder (OUD) do not receive evidence-based lifesaving medications.

29 Jul 2024

DNA repair gene mutations predict bladder cancer response to neoadjuvant chemotherapy

An analysis of pre-treatment tumor specimens from 105 patients with localized muscle-invasive bladder cancer found that the presence of a mutation in any one of three genes, all known to be involved in DNA damage repair, was associated with complete pathologic response to cisplatin-based neoadjuvant chemotherapy as measured by pathological downstaging at the time of bladder surgery.

29 Jul 2024

FDA-approved iron-chelating drug could provide a novel way to attack ovarian tumors

An iron-binding drug that is already approved for treatment of other diseases could provide a novel way to attack ovarian tumors, according to a new study led by Weill Cornell Medicine researchers.

29 Jul 2024

Lettuce found comparable to dock leaf for nettle sting relief

Rubbing a lettuce leaf on a nettle sting to ease the associated discomfort may be just as good as using the age-old folk remedy of a dock leaf, suggest the results of a small comparative study, published online in Emergency Medicine Journal.

29 Jul 2024

Overcoming cancer relapse with CAR-Enhancer therapy

Even as they have revolutionized the treatment of certain forms of cancer, CAR T-cell therapies have been shadowed by a significant limitation: many patients, including those whose cancer goes into full remission, eventually relapse. In a new study, Dana-Farber Cancer Institute researchers report on a technique with the potential to eliminate that problem.

29 Jul 2024

Pharmacist cautions against self-medicating with ozempic for dementia risk reduction

“According to the latest figures released by the NHS, dementia diagnosis is at a record high in England.

29 Jul 2024

Researchers to trial ground-breaking screening test for pre-eclampsia

Researchers are to trial a ground-breaking screening test for pre-eclampsia, a potentially life-threatening condition affecting pregnant women and their unborn babies.

29 Jul 2024

Motor neurone disease research receives major boost through new data catalyst initiative

Research into the life-shortening neurological condition motor neurone disease (MND) will receive a major boost through the formation of a new data catalyst led by Health Data Research UK (HDR UK) and Dementia Platforms UK (DPUK).

29 Jul 2024

Insilico Medicine unveils Science42:DORA to streamline academic writing and research

Writing research papers is critical for disseminating scientific findings, but it does come with efficiency burdens, particularly for early-career researchers and non-native English speakers.

28 Jul 2024

Impact of evidence-based information on women's decisions about anti-Mullerian hormone testing

Researchers in Australia have found that when women are given accurate information about a test that indicates the number of eggs in their ovaries, they have less interest in taking the test compared to women who viewed information available online.

28 Jul 2024

Medicaid policies boost oncology clinical trial enrollment for Black and Hispanic patients

Two Medicaid policies can interact to increase oncology clinical trial enrollment among Black and Hispanic patients, according to a new study by investigators at Weill Cornell Medicine, the University of Pennsylvania, and Medidata AI.

25 Jul 2024

Experimental cancer drug may help clear HIV from infected cells in the brain

An experimental drug originally developed to treat cancer may help clear HIV from infected cells in the brain, according to a new Tulane University study.

25 Jul 2024

Insilico Medicine's PandaOmics Box enhances drug discovery with advanced AI capabilities

The development of innovative medicines is an expensive, time-consuming and risky business. On average, it usually takes at least a decade and billions of dollars to bring a new drug from project initiation to approval.

25 Jul 2024

UK initiative aims to transform MND research through health data collaboration

MND is a devastating disease affecting the motor neurones in the brain and spinal cord, leading to progressive muscle weakness and paralysis.

25 Jul 2024

Posterior foraminotomy shows comparable results to anterior discectomy for cervical radiculopathy

For patients with cervical radiculopathy, posterior foraminotomy provides outcomes comparable to those of the more commonly performed anterior cervical discectomy, reports a randomized clinical trial in The Journal of Bone & Joint Surgery.

25 Jul 2024

Fecal microbiota transplants can boost the effectiveness of immunotherapy in gastrointestinal cancers

Findings from a small, proof-of-concept clinical trial have suggested that fecal microbiota transplants (FMTs) can boost the effectiveness of immunotherapy in a range of gastrointestinal cancers.

25 Jul 2024

Texas Heart Institute and BiVACOR achieve milestone with total artificial heart implantation

The Texas Heart Institute (THI) and BiVACOR, a clinical-stage medical device company, announced today the successful first-in-human implantation of the BiVACOR Total Artificial Heart (TAH) as part of the U.S. Food and Drug Administration (FDA) Early Feasibility Study (EFS) on July 9, 2024.

25 Jul 2024

Clinical Trial News and Research

New dual-chamber wireless pacemaker shows reliable performance in clinical trial

Study reveals curcumin’s antidepressant effects in obese type 2 diabetes patients

Genetic variants associated with Parkinson's more common than estimated

Hospital-based addiction consult services show promise in improving opioid use disorder treatment uptake

DNA repair gene mutations predict bladder cancer response to neoadjuvant chemotherapy

FDA-approved iron-chelating drug could provide a novel way to attack ovarian tumors

Lettuce found comparable to dock leaf for nettle sting relief

Overcoming cancer relapse with CAR-Enhancer therapy

Pharmacist cautions against self-medicating with ozempic for dementia risk reduction

Researchers to trial ground-breaking screening test for pre-eclampsia

Motor neurone disease research receives major boost through new data catalyst initiative

Insilico Medicine unveils Science42:DORA to streamline academic writing and research

Impact of evidence-based information on women's decisions about anti-Mullerian hormone testing

Medicaid policies boost oncology clinical trial enrollment for Black and Hispanic patients

Experimental cancer drug may help clear HIV from infected cells in the brain

Insilico Medicine's PandaOmics Box enhances drug discovery with advanced AI capabilities

UK initiative aims to transform MND research through health data collaboration

Posterior foraminotomy shows comparable results to anterior discectomy for cervical radiculopathy

Fecal microbiota transplants can boost the effectiveness of immunotherapy in gastrointestinal cancers

Texas Heart Institute and BiVACOR achieve milestone with total artificial heart implantation

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