Clinical Trial News and Research

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Spirituality and distrust influence Black patients' participation in cancer trials

Spiritual beliefs and a historically-based distrust of clinical research may factor into Black patients' decisions about whether to participate in cancer trials, according to surveys of patients treated at two Baltimore medical centers.

30 Sep 2024

Atherosclerosis burden and progression predict all-cause mortality

A study carried out at Mount Sinaí Fuster Heart Hospital in New York in collaboration with the Centro Nacional de Investigaciones Cardiovasculares (CNIC) in Madrid provides important new information about atherosclerosis, a disease in which lipids (cholesterol) and other substances accumulate in plaques on the arterial wall, causing the vessels to harden and narrow, and increasing the risk of severe cardiovascular conditions.

30 Sep 2024

Study shows equal effectiveness of proton beam therapy and IMRT for prostate cancer

People with low- and intermediate-risk prostate cancer treated with either of two types of contemporary radiation therapy - proton beam therapy or intensity modulated radiation therapy (IMRT) - achieved equally high rates of tumor control with no differences in patient-reported quality of life, according to a first-of-its-kind phase III clinical trial comparing the two technologies. Findings of the PARTIQoL trial will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting.

30 Sep 2024

New noninvasive device promises early stroke risk detection

A team of researchers from the Keck School of Medicine of USC and California Institute of Technology (Caltech) have developed a potential new way to measure a person's stroke risk that is cost-effective and noninvasive, akin to a cardiac stress test.

30 Sep 2024

Extending survival in meningioma patients with innovative radiopharmaceutical therapy

A radiopharmaceutical therapy that has successfully extended progression-free survival for patients with neuroendocrine tumors shows early promise for delivering similar benefits to patients with difficult-to-treat meningioma, a type of brain tumor.

29 Sep 2024

Glutathione found to significantly reduce acetaldehyde levels and help relieve hangovers

Study demonstrates that glutathione (GSH) significantly reduces acetaldehyde levels, a key factor in hangovers, though subjective symptoms showed little difference between groups. Pharmacokinetic data indicate that GSH accelerates acetaldehyde clearance, providing potential relief from hangover symptoms.

29 Sep 2024

UCLA Health researchers showcase advances in radiation oncology at ASTRO

UCLA Health Jonsson Comprehensive Cancer Center researchers and physicians who specialize in treating patients with radiation therapies will present data on the latest radiation oncology research and clinical trial results at the 66th annual American Society for Radiation Oncology (ASTRO) meeting in Washington D.C., Sept. 29 to Oct. 2.

27 Sep 2024

A randomized trial of mexiletine and lamotrigine in adults with non-dystrophic myotonia

The study, published in Lancet Neurology, detailed the "head-to-head" trial implemented by the researchers to test two drugs, mexiletine and lamotrigine, on people with the condition.

27 Sep 2024

Review highlights evolving role of endovascular therapy in treating ischemic stroke

Stroke related to large vessel occlusion (LVO) is a leading cause of disability and death worldwide. Endovascular therapy (minimally invasive procedures like catheterization done inside the blood vessels) has transformed the management of these patients.

26 Sep 2024

Innovative CAR-T cells effectively target glioblastoma with reduced toxicity

Glioblastoma is the most common and most aggressive primary brain tumor, with an average survival after diagnosis of less than two years, and against which current treatments remain ineffective.

26 Sep 2024

High rate of iron deficiency among pregnant women in Ireland revealed

Four out of five pregnant women in Ireland are iron deficient by their third trimester, a University College Cork (UCC) study reveals.

26 Sep 2024

Targeted drug therapy shows promise for ulcerative colitis remission

An international placebo-controlled study led by Cedars-Sinai suggests that a targeted drug therapy that was developed by researchers at Cedars-Sinai is safe and effective at helping people with moderate to severe ulcerative colitis reach clinical remission.

26 Sep 2024

Targeted therapy improves pregnancy outcomes

Amongst women who experience recurrent pregnancy loss, around 20% test positive for a specific antibody that targets the mother's own body. A Kobe University-led research team now found a treatment that drastically increases these women's chances of carrying to full-term without complications.

26 Sep 2024

Study reveals life-changing impact of gene therapy for hemophilia B patients

Adults with hemophilia B saw their number of bleeding episodes drop by an average of 71 percent after a single infusion of gene therapy, according to the results of an international Phase III clinical trial published today in the New England Journal of Medicine by researchers from the University of Pennsylvania Perelman School of Medicine and a multicenter group of investigators.

25 Sep 2024

Remote video consultations show positive impact on depression and anxiety

Remote video consultations between patients and mental health specialists show a small but significant improvement on symptoms of depression and anxiety, finds a trial published by The BMJ today.

25 Sep 2024

Concerns raised over safety and effectiveness of donanemab for Alzheimer’s treatment

The safety and effectiveness of donanemab - an Alzheimer's drug recently approved by the US Food & Drug Administration (FDA) - is called into question in an investigation published by The BMJ today.

25 Sep 2024

Study links semaglutide to reduced opioid overdose risk in patients with OUD and diabetes

Since being deemed a public health emergency in 2017, opioids are responsible for 72% of drug overdose deaths in the United States, according to the National Center for Drug Abuse Statistics.

25 Sep 2024

University of Pittsburgh receives $100 million to enhance trauma care research

The University of Pittsburgh Schools of the Health Sciences has been awarded approximately $100 million from the U.S. Department of Defense (DOD) to continue a clinical research program that is advancing trauma care.

25 Sep 2024

Steritas' Pediatric Glucocorticoid Toxicity Index applied in clinical trial to assess steroid-toxicity

Steritas LLC., a company dedicated to enhancing patient care for steroid-treated patients announced that Alder Hey Children’s NHS Foundation Trust, and the Liverpool Clinical Trials Centre will apply its Steritas Pediatric Glucocorticoid Toxicity Index (pGTI) in a clinical trial to compare efficacy, safety and cost-effectiveness of intravenous versus oral glucocorticoids (steroids) for children and young people with Juvenile Idiopathic Arthritis (JIA).

From Steritas LLC 25 Sep 2024

New approach to B-ALL treatment reduces side effects and enhances survival

Clinical trial results from St. Jude Children's Research Hospital demonstrate benefits to using genomics and early treatment response to guide risk classification of children with B-cell acute lymphoblastic leukemia (B-ALL).

24 Sep 2024

Clinical Trial News and Research

Spirituality and distrust influence Black patients' participation in cancer trials

Atherosclerosis burden and progression predict all-cause mortality

Study shows equal effectiveness of proton beam therapy and IMRT for prostate cancer

New noninvasive device promises early stroke risk detection

Extending survival in meningioma patients with innovative radiopharmaceutical therapy

Glutathione found to significantly reduce acetaldehyde levels and help relieve hangovers

UCLA Health researchers showcase advances in radiation oncology at ASTRO

A randomized trial of mexiletine and lamotrigine in adults with non-dystrophic myotonia

Review highlights evolving role of endovascular therapy in treating ischemic stroke

Innovative CAR-T cells effectively target glioblastoma with reduced toxicity

High rate of iron deficiency among pregnant women in Ireland revealed

Targeted drug therapy shows promise for ulcerative colitis remission

Targeted therapy improves pregnancy outcomes

Study reveals life-changing impact of gene therapy for hemophilia B patients

Remote video consultations show positive impact on depression and anxiety

Concerns raised over safety and effectiveness of donanemab for Alzheimer’s treatment

Study links semaglutide to reduced opioid overdose risk in patients with OUD and diabetes

University of Pittsburgh receives $100 million to enhance trauma care research

Steritas' Pediatric Glucocorticoid Toxicity Index applied in clinical trial to assess steroid-toxicity

New approach to B-ALL treatment reduces side effects and enhances survival

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