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Effects of hybrid immunity on humoral immune response following COVID mRNA vaccination in a cohort of essential and frontline workers

Researchers longitudinally evaluated humoral immune responses to the second and third doses of COVID-19 mRNA vaccines among individuals with and without prior history of SARS-CoV-2 infections.

3 Jan 2023

What is the impact of COVID-19 on the human genetic architecture?

Researchers recently described the second update on the study of human genetic architecture with respect to the effect of coronavirus disease 2019 (COVID-19).

3 Jan 2023

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

An enzyme that defends human cells against viruses can help drive cancer evolution towards greater malignancy by causing myriad mutations in cancer cells, according to a study led by investigators at Weill Cornell Medicine.

28 Dec 2022

Scientists explore synthesis of griffithsin in cell-free systems

A new study described the cell-free manufacturing of griffithsin (GRFT), a broad-spectrum antiviral protein.

28 Dec 2022

A genome-based comparison of SARS-CoV-2 XBB recombinant and its parental lineage

In a recent study posted to the bioRxiv* preprint server, researchers in Italy performed a genome-based comparison of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) XBB recombinant with its parental lineages.

27 Dec 2022

Hybrid immunity from mRNA vaccines and breakthrough Omicron infections induces stronger immune responses against Omicron BQ.1.1

Researchers evaluated plasma samples from individuals vaccinated with a fourth booster dose of mono- or bivalent mRNA SARS-CoV-2 vaccine to evaluate the recognition and neutralization capacity against the ancestral (D614G) strain and the Omicron BQ.1.1 subvariant.

23 Dec 2022

Decade-long search in one-celled, fresh water dwelling organism solves puzzle involved in gene regulation

After an intrepid, decade-long search, Johns Hopkins Medicine scientists say they have found a new role for a pair of enzymes that regulate genome function and, when missing or mutated, are linked to diseases such as brain tumors, blood cancers and Kleefstra syndrome - a rare genetic, neurocognitive disorder.

22 Dec 2022

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

A phase I clinical trial of PAC-1, a drug that spurs programmed cell death in cancer cells, found only minor side effects in patients with end-stage cancers.

22 Dec 2022

UMass Amherst microbiologist receives NIH grant to develop more effective treatments for tuberculosis

A microbiologist at the University of Massachusetts Amherst has received a National Institutes of Health grant to support research aimed ultimately at developing new, more effective treatments for tuberculosis (TB).

21 Dec 2022

SARS-CoV-2 and human cold coronavirus OC43 inhibit stress granule formation through Nsp15 protein

Researchers investigated the mechanisms through which the human common cold Betacoronavirus OC43 (HCoV-OC43) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibit the formation of stress granules.

21 Dec 2022

Review on nanoparticles usage for treating thrombosis induced by SARS-CoV-2 infections

Researchers provided an overview of nanomedicine strategies to treat coronavirus disease 2019 (COVID-19)-induced thrombosis.

21 Dec 2022

Enzyme inhibition reduces cancer-related bone loss and the number of bone metastases

In our bones, specialized cells called osteoblasts are responsible for building up bone substance. A team of researchers led by scientists from the DKFZ-Hector Cancer Institute at the University Medical Center Mannheim and the University Medical Center Hamburg Eppendorf has now identified an enzyme that controls the activity of osteoblasts.

20 Dec 2022

Use of anti-inflammatory drugs by children may be associated with dental enamel defects

A study conducted at the University of São Paulo in Brazil and described in an article published in the journal Scientific Reports shows that anti-inflammatory drugs commonly taken by children may be associated with dental enamel defects (DEDs), currently seen in about 20% of children worldwide.

20 Dec 2022

Trial of three vaccines for Zaire Ebola virus disease

Researchers perform two randomized controlled trials to determine immunogenicity and safety of three Ebola vaccines.

20 Dec 2022

Study finds several flavor/fragrance compositions that inhibit vRBD-hACE2 binding

A study describes the antiviral activity of flavor/fragrance compositions against SARS-CoV-2.

20 Dec 2022

Kraft Heinz joins with Wyss Institute to reduce sugar content in foods

When most people think of The Kraft Heinz Company, their minds probably jump to two iconic food products: Kraft mac & cheese and Heinz tomato ketchup.

20 Dec 2022

SARS-CoV-2 structural proteins trigger periodontal fibrosis

Researchers examined the pathological impacts of the structural components of SARS-CoV-2 on human periodontal cells and tissue to understand the association between coronavirus disease 2019 (COVID-19) and deteriorating oral health.

20 Dec 2022

Seroprevalence measurements reveal a higher incidence of asymptomatic SARS-CoV-2 infections among residents of three federal German states

Researchers measured the seroprevalence against SARS-CoV-2 in blood donors from the states of Hesse, Lower Saxony, and North Rhine-Westphalia in Germany to determine the incidence of undetected asymptomatic SARS-CoV-2 infections.

20 Dec 2022

Researchers generate a remodeled live-attenuated measles vaccine capable of driving nAb responses against SARS-CoV-2 spike protein

Researchers developed a measles virus (MeV)-vectored vaccine capable of inducing high neutralizing antibody (nAb) responses against SARS-CoV-2.

20 Dec 2022

What is the impact of cholesterol on SARS-CoV-2 Spike protein-mediated membrane fusion?

Researchers assessed the impact of ceramide (CER) and cholesterol (CHOL) on membrane fusion mediated by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein.

20 Dec 2022

Enzyme News and Research

Effects of hybrid immunity on humoral immune response following COVID mRNA vaccination in a cohort of essential and frontline workers

What is the impact of COVID-19 on the human genetic architecture?

Enzyme that defends human cells against viruses may be a potential target for future cancer treatments

Scientists explore synthesis of griffithsin in cell-free systems

A genome-based comparison of SARS-CoV-2 XBB recombinant and its parental lineage

Hybrid immunity from mRNA vaccines and breakthrough Omicron infections induces stronger immune responses against Omicron BQ.1.1

Decade-long search in one-celled, fresh water dwelling organism solves puzzle involved in gene regulation

Phase I clinical trial of PAC-1 in patients with end-stage cancers shows promising results

UMass Amherst microbiologist receives NIH grant to develop more effective treatments for tuberculosis

SARS-CoV-2 and human cold coronavirus OC43 inhibit stress granule formation through Nsp15 protein

Review on nanoparticles usage for treating thrombosis induced by SARS-CoV-2 infections

Enzyme inhibition reduces cancer-related bone loss and the number of bone metastases

Use of anti-inflammatory drugs by children may be associated with dental enamel defects

Trial of three vaccines for Zaire Ebola virus disease

Study finds several flavor/fragrance compositions that inhibit vRBD-hACE2 binding

Kraft Heinz joins with Wyss Institute to reduce sugar content in foods

SARS-CoV-2 structural proteins trigger periodontal fibrosis

Seroprevalence measurements reveal a higher incidence of asymptomatic SARS-CoV-2 infections among residents of three federal German states

Researchers generate a remodeled live-attenuated measles vaccine capable of driving nAb responses against SARS-CoV-2 spike protein

What is the impact of cholesterol on SARS-CoV-2 Spike protein-mediated membrane fusion?

Understanding the DNA Damage Response in Innate Immunity eBook

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Industry Focus eBook - Analytical Chemistry (3rd edition)

Industry Focus eBook - Microbiome (1st edition)

Industry Focus eBook - Cell biology (5th edition)

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Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo