Fibrosis News and Research

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Fibrosis is the growth of fibrous tissue.

Diabetes medication can protect against cardiac stiffening in obese female mice

Overconsumption of a Western diet high in fats and refined sugars has contributed to a global increase in obesity and Type 2 diabetes.

6 Jun 2017

Patients who undergo Fontan surgery for congenital heart defect have liver fibrosis risk, study reveals

Patients who undergo the Fontan operation as children for a complex congenital heart defect are at risk of developing progressive liver fibrosis, a buildup of fibrous deposits, as a result of the circulation created by the surgery, according to a new study.

31 May 2017

New drug offers hope to patients with hepatitis C

Patients with hepatitis C who suffer from advanced stages of liver disease have renewed hope, thanks to findings by researchers who have discovered that a new drug significantly reduces their risk of death and need for transplantation.

26 May 2017

Newly developed ultrafast cardiac imaging test changes clinical management in one-third of patients

Researchers in the UK and Peru have developed a faster and cheaper cardiac imaging test that can be used in developing countries, according to the results of the INCA-Peru study presented today at EuroCMR 2017.

26 May 2017

ERT’s Centralized LCI Services improve data quality to measure disease progression in respiratory clinical trials

ERT, a global data and technology company that minimizes uncertainty and risk in clinical trials, today introduced an advanced respiratory clinical trial solution to centrally capture, measure and analyze Lung Clearance Index data, in near real-time, to assess lung performance with more precision than traditional spirometry measures.

26 May 2017

Study identifies two T cell biomarkers that may predict survival trajectory of IPF patients

Two T cell biomarkers appear to predict the survival trajectory of patients with idiopathic pulmonary fibrosis (IPF), a lung disease that has a varied, but ultimately devastating, impact on patients, according to new research presented at the ATS 2017 International Conference.

22 May 2017

Study provides new understanding of silent gene changes and genetic complexity of cystic fibrosis

Cystic fibrosis is a common life-shortening inherited disease that affects over 70,000 people worldwide, the majority of whom are children and young adults.

18 May 2017

FDA expands approval for cystic fibrosis drug to treat additional rare gene mutations

The U.S. Food and Drug Administration today expanded the approved use of Kalydeco (ivacaftor) for treating cystic fibrosis.

18 May 2017

Researchers identify key inflammatory cells involved in nonalcoholic fatty liver disease

A team of investigators led by Rohit Kohli, MBBS, MS, of Children's Hospital Los Angeles, has identified key inflammatory cells involved in nonalcoholic fatty liver disease.

17 May 2017

MAGNET study: MRE can be accurate, non-invasive tool to detect liver fibrosis in children

Researchers at University of California San Diego School of Medicine, with collaborators across the nation, have determined that magnetic resonance elastography can be an accurate, non-invasive tool to identify liver fibrosis in children.

12 May 2017

Discovery of key signals in the lungs and liver could pave way for immune disorder treatments

The discovery of key signals that help tissues repair after injury could pave the way for new treatments for asthma and organ scarring, a study suggests.

12 May 2017

CUMC researchers create new organoids that mimic features of full-sized lung

New lung "organoids"-tiny 3-D structures that mimic features of a full-sized lung- have been created from human pluripotent stem cells by researchers at Columbia University Medical Center. The team used the organoids to generate models of human lung diseases in a lab dish, which could be used to advance our understanding of a variety of respiratory diseases.

11 May 2017

Researchers identify microRNA biomarker linked to incidence of atrial fibrillation

Researchers have identified a microRNA biomarker that demonstrates a strong association with the incidence of atrial fibrillation, the most common abnormal heart rhythm that affects more than 2.7 million Americans.

11 May 2017

TSRI scientists uncover regulatory machinery underlying the function of cancer protein

Despite intense research, there's been much confusion regarding the exact role of a protein in a critical cancer-linked pathway. On one hand, the protein is described as a cell proliferation inhibitor, on the other, a cell proliferation activator, a duality that has caused a great deal of scientific head scratching.

5 May 2017

Scientists grow and purify earliest lung progenitors from human stem cells

Human lungs, like all organs, begin their existence as clumps of undifferentiated stem cells. But in a matter of months, the cells get organized. They gather together, branch and bud, some forming airways and others alveoli, the delicate sacs where our bodies exchange oxygen for carbon dioxide.

3 May 2017

Shire and Parion Sciences to collaborate on P-321 for ophthalmic indications

Shire plc and Parion Sciences, Inc. have announced they have entered into an agreement granting Shire exclusive worldwide rights to develop and commercialize P-321. Shire will lead development of P-321, an investigational epithelial sodium channel (ENaC) inhibitor for the potential treatment of dry eye disease in adults, with the opportunity for Parion to co-fund.

3 May 2017

Fibrosis News and Research

Further Reading

Diabetes medication can protect against cardiac stiffening in obese female mice

Patients who undergo Fontan surgery for congenital heart defect have liver fibrosis risk, study reveals

New drug offers hope to patients with hepatitis C

Newly developed ultrafast cardiac imaging test changes clinical management in one-third of patients

ERT’s Centralized LCI Services improve data quality to measure disease progression in respiratory clinical trials

Study identifies two T cell biomarkers that may predict survival trajectory of IPF patients

Study provides new understanding of silent gene changes and genetic complexity of cystic fibrosis

FDA expands approval for cystic fibrosis drug to treat additional rare gene mutations

Researchers identify key inflammatory cells involved in nonalcoholic fatty liver disease

MAGNET study: MRE can be accurate, non-invasive tool to detect liver fibrosis in children

Discovery of key signals in the lungs and liver could pave way for immune disorder treatments

CUMC researchers create new organoids that mimic features of full-sized lung

Researchers identify microRNA biomarker linked to incidence of atrial fibrillation

TSRI scientists uncover regulatory machinery underlying the function of cancer protein

Scientists grow and purify earliest lung progenitors from human stem cells

Shire and Parion Sciences to collaborate on P-321 for ophthalmic indications

Discovery of protein that causes liver disease brings hope for new treatments

Study sets stage for potential stool-based test to detect advanced liver fibrosis

Knocking out lipid-modifying enzyme can boost post-heart attack healing, study shows

New technique dramatically accelerates search for new cancer treatments

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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