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Parkinson’s disease linked to genetic alteration of immune system: Study

Parkinson’s disease (PD), a severely crippling disease of the nerves and brain has been linked to genes that affect the immune system according to new research. In these patients the immune system may go awry attacking healthy tissues or failing to fight infections that leave people susceptible to the condition scientists say.

16 Aug 2010

Fertility preservation may be unsafe for leukemia patients: Study

Although the use of ovarian tissue cryopreservation and transplantation has lead to 13 live births in women with lymphoma or solid tumors, this method of fertility preservation may be unsafe for patients with leukemia, according to a recent study published online in Blood, the journal of the American Society of Hematology.

16 Aug 2010

Common genetic variation in HLA region associated with late-onset sporadic Parkinson's disease: Research

A team of researchers has discovered new evidence that Parkinson's disease may have an infectious or autoimmune origin. "Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease" appears online in Nature Genetics.

16 Aug 2010

Scientists find therapeutic potential of stem cells for acute lung injury

Researchers are reporting this week new study results they say provide further evidence of the therapeutic potential of stem cells derived from bone marrow for patients suffering from acute lung injury, one of the most common causes of respiratory failure in intensive care units.

12 Aug 2010

NKTreg white blood cells migrate into liver, suppress immune responses: Research

After a transplant - and to assure that the new organ is not rejected - patients are put on life-long therapy to suppress their immune system, which, nevertheless, needs to be left intact enough to be able to defend the body against all kinds of disease. A tricky balance as the many rejected organs attest. But a discovery by Maria Monteiro and Luis Graça, two Portuguese scientists, could change all this, at least for the liver.

11 Aug 2010

Study results provide rationale for use of PI3K inhibitors in therapeutic settings

Research at the Babraham Institute, investigating how white blood cells known as B cells develop, has revealed that genes from the Phosphatidylinositol 3-kinase family of enzymes are critical in enabling the B cells to produce antibodies in the spleen and lymph nodes.

10 Aug 2010

New familial link in juvenile myelomonocytic leukemia discovered

A UCSF-led team has discovered a direct link between an inherited genetic mutation, a set of developmental abnormalities and a rare form of childhood leukemia called juvenile myelomonocytic leukemia, or JMML. The study demonstrates a new familial link in JMML and has significant implications, the researchers say, for improving the diagnosis and treatment of the disease.

9 Aug 2010

Vesicular stomatitis virus kills tumour, stimulates immune response against cancer: Research

Cancer Research UK scientists have used the immune system coupled with a virus found in horses and cattle, to hunt and purge cancer cells through the lymphatic system, a study reveals in Nature Medicine.Studying mice, the researchers found that the vesicular stomatitis virus (VSV), carried by a type of white blood cell called T cells acted as a 'cancer hunter', tracking down tumour cells in the lymph nodes, liver and spleen, and killed them, leaving normal healthy cells unharmed. At the same time, VSV also helped to trigger an immune response against the tumour, significantly improving the anti-cancer effect.

6 Aug 2010

Life Technologies, UCSD Moores Cancer Center to use SOLiD 4 technology to study CLL

Life Technologies Corporation and the University of California at San Diego Moores Cancer Center today announced a partnership to use SOLiD 4 genomic analysis technology in a research program to study chronic lymphocytic leukemia, a cancer of the white blood cells. The CLL research is made possible by funding from the National Institutes of Health and will enable scientists to survey the whole transcriptomes of 96 CLL tumor samples for potential biomarkers.

5 Aug 2010

Scientists identify tiny RNA molecule that increases blood stem cells

Investigators have identified a new mechanism that controls the number of hematopoietic stem cells - cells that give rise to all blood and immune system cells. In a report in the online Early Edition of Proceedings of the National Academy of Sciences, researchers from Massachusetts General Hospital (MGH) and the Harvard Stem Cell Institute identify a tiny RNA molecule that increases the number of these blood stem cells, an advance that may improve treatment of blood system cancers.

5 Aug 2010

Certain human leukemias can be treated by targeting stem-cell microRNAs: Research

Hematopoietic stem cells provide the body with a constant supply of blood cells, including the red blood cells that deliver oxygen and the white blood cells that make up the immune system. Hematopoietic-or blood-stem cells must also make more copies of themselves to ensure that they are present in adequate numbers to provide blood throughout a person's lifetime, which means they need to strike a delicate balance between self-renewal and development into mature blood-cell lineages. Perturb that balance, and the result can be diseases such as leukemia and anemia.

5 Aug 2010

New article published in Journal of Surgical Research highlights PACE technology

SANUWAVE Health, Inc., an emerging medical technology company focused on the development and commercialization of non-invasive, biological response activating devices in regenerative medicine, today announced that an article titled "Microvascular Response to Shock Wave Application in Striated Skin Muscle" was recently published in the on-line edition of the Journal of Surgical Research.

4 Aug 2010

Access Pharmaceuticals initiates Phase I/II dose escalating study for Thiarabine

Access Pharmaceuticals, Inc., today announced it has initiated a Phase I/II dose-escalating study of its proprietary, anti-cancer drug, Thiarabine, a nucleoside analog for patients with hematologic malignancies (cancers of the blood). The primary objective of the study is to determine the maximum tolerated dose (MTD) in two different dosing schedules with various leukemias and lymphomas and recommended Phase II dose. The program is being led by Hagop Kantarjian, M.D., Chair of the Department of Leukemia at The University of Texas MD Anderson Cancer Center in Houston, Texas.

4 Aug 2010

Research findings could lead to new drugs that reduce severity of blood infections leading to sepsis

Scientists have made an important discovery that could lead to new drugs that reduce the severity of blood infections leading to sepsis. Research presented in the August 2010 issue of Journal of Leukocyte Biology shows how interfering with the function of the cell membrane protein called "Programmed Death 1" (PD-1) improves survival in a clinically relevant model of severe infection.

2 Aug 2010

Body’s natural cell suicide program may trigger tumor development: Study

Cancer research springs a surprise. Researchers at Walter and Eliza Hall Institute in Melbourne have found that programmed cell death (apoptosis) or cell suicide plays a role in tumor development. This process is an important phenomenon in our body as it helps remove damaged cells. Now apoptosis has been found to be protective against cancer formation and autoimmune diseases.

1 Aug 2010

White button mushrooms can keep the immune system healthy: Study

Mushrooms are among the many foods thought to play an important role in keeping the immune system healthy. Now, Agricultural Research Service funded scientists have conducted an animal-model and cell-culture study showing that white button mushrooms enhanced the activity of critical cells in the body's immune system.

30 Jul 2010

New paradigm in TB research may lead to improved vaccination, treatment

Often causing no symptoms in carriers of the disease, worldwide tuberculosis (TB) infects eight to ten million people every year, kills two million, and it is highly contagious as it is spread through coughing and sneezing. "It's a global health disaster waiting to happen, even here in Canada, but this new paradigm in TB research may offer an immediate opportunity to improve vaccination and treatment initiatives," explains Dr. Maziar Divangahi of McGill University and of the Research Institute of the McGill University Health Centre.

30 Jul 2010

Positive results from study with Genome Sequencer FLX System for HIV drug-resistant mutation detection

454 Life Sciences, a Roche Company, has announced promising new results from a multi-site collaborative research study which used the company's Genome Sequencer FLX System to perform HIV drug-resistant mutation detection.

28 Jul 2010

Sysmex America to debut expanded cell image analysis portfolio at AACC Annual Conference

Sysmex America, Inc., a leading medical diagnostic instrument manufacturer and information systems developer, today announced plans to debut its expanded cell image analysis portfolio during this year's American Association of Clinical Chemistry's (AACC) Annual Conference and Clinical Lab Expo July 25 - 29 in Anaheim, California.

From Sysmex America, Inc. 27 Jul 2010

Hospira commences EPO Phase I U.S. clinical trial in renal dysfunction patients with anemia

Hospira, Inc., the world leader in generic injectable pharmaceuticals, today announced the start of a U.S. Phase I clinical trial of its biosimilar erythropoietin (EPO) in patients with renal (kidney) dysfunction who have anemia, an important step on the road toward introducing a biosimilar product in the United States. Erythropoietin is a treatment for anemia associated with chronic renal failure and chemotherapy.

26 Jul 2010

Leukocyte News and Research

Parkinson’s disease linked to genetic alteration of immune system: Study

Fertility preservation may be unsafe for leukemia patients: Study

Common genetic variation in HLA region associated with late-onset sporadic Parkinson's disease: Research

Scientists find therapeutic potential of stem cells for acute lung injury

NKTreg white blood cells migrate into liver, suppress immune responses: Research

Study results provide rationale for use of PI3K inhibitors in therapeutic settings

New familial link in juvenile myelomonocytic leukemia discovered

Vesicular stomatitis virus kills tumour, stimulates immune response against cancer: Research

Life Technologies, UCSD Moores Cancer Center to use SOLiD 4 technology to study CLL

Scientists identify tiny RNA molecule that increases blood stem cells

Certain human leukemias can be treated by targeting stem-cell microRNAs: Research

New article published in Journal of Surgical Research highlights PACE technology

Access Pharmaceuticals initiates Phase I/II dose escalating study for Thiarabine

Research findings could lead to new drugs that reduce severity of blood infections leading to sepsis

Body’s natural cell suicide program may trigger tumor development: Study

White button mushrooms can keep the immune system healthy: Study

New paradigm in TB research may lead to improved vaccination, treatment

Positive results from study with Genome Sequencer FLX System for HIV drug-resistant mutation detection

Sysmex America to debut expanded cell image analysis portfolio at AACC Annual Conference

Hospira commences EPO Phase I U.S. clinical trial in renal dysfunction patients with anemia

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