Metabolites News and Research

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Study reveals intriguing crosstalk between metabolism and epigenetics in cancer development

A study published in Briefings in Functional Genomics investigated how epigenetics can modulate human's genetic program -- it can emphasize or silence genes.

24 Mar 2017

Fat cells take over production of uridine from liver during fasting

How do mammals keep two biologically crucial metabolites in balance during times when they are feeding, sleeping, and fasting? The answer may require rewriting some textbooks.

17 Mar 2017

First physiological test opens door to early diagnosis of autism

An algorithm based on levels of metabolites found in a blood sample can accurately predict whether a child is on the Autism spectrum of disorder (ASD), based upon a recent study.

16 Mar 2017

Researchers probe potential link between gut microbiota and poor artery health

Scientific evidence that the assortment of gut microbes in humans influences different and critical aspects of health is piling up: Researchers think our microbes may influence obesity, anxiety, depression, autism, cancer and gastrointestinal diseases.

1 Mar 2017

Decoding the Exposome Through Breath Biomarkers

The human exposome is probably best defined as “everything that is not the genome.” This is a bit tongue in cheek, but basically, the exposome is comprised of all of the chemicals in your body from the environment, food, consumer products, their metabolites, the endogenous “housekeeping” chemicals, the cellular wastes from energy production, as well as all of the messenger compounds and life supporting chemicals.

From Pittcon 24 Feb 2017

Researchers develop new tool that quickly reveals metabolic fluxes in cells

If we were to take photographs at the underground stations in Barcelona, we would see the number of people waiting, find out what time the rush hour takes place and deduce why some stations are busier than others.

23 Feb 2017

Duke Health scientists identify proteins in mucous that confirm viral infection

It may seem obvious, but the key to confirming whether someone is suffering from a cold or flu virus might lie at the misery's source -- the inflamed passages of the nose and throat.

22 Feb 2017

Discovery of early biomarkers paves way for new insight into Huntington's disease

Early warning signs of Huntington's disease have been uncovered in a sheep carrying the human HD mutation, leading the way for new insight into this devastating illness, a new study in Scientific Reports has found.

22 Feb 2017

Melanoma patients' immunotherapy response linked to diversity and makeup of gut bacteria

Melanoma patients' response to a major form of immunotherapy is associated with the diversity and makeup of trillions of potential allies and enemies found in the digestive tract, researchers at The University of Texas MD Anderson Cancer Center report at the ASCO-Society for Immunotherapy in Cancer meeting in Orlando.

22 Feb 2017

UofL researcher receives NIH grant to study microbes responsible for protecting against malaria

Nathan Schmidt, Ph.D., has published research showing that microbes in the gut of mice can affect the severity of illness suffered from infection with Plasmodium, the parasite that causes malaria.

21 Feb 2017

Caffeine cannot prevent memory deficits linked to alcohol consumption, study finds

A study recently published in Frontiers in Behavioral Neuroscience indicates that despite its impact on alertness and concentration, caffeine cannot counteract the memory deficits that result from alcohol consumption.

20 Feb 2017

Mice study provides clues to how genetic variations in gut microbes influence metabolic disease

The community of microorganisms that resides in the gut, known as the microbiome, has been shown to work in tandem with the genes of a host organism to regulate insulin secretion, a key variable in the onset of the metabolic disease diabetes.

17 Feb 2017

Instrument for blood gas and glucose analysis launched by Sphere Medical

Sphere Medical, an innovative company in critical care monitoring and diagnostics equipment, will be showcasing for the first time its next generation Proxima™ blood gas analyser to a German critical care audience at both the Symposium Intensivmedizin + Intensivpflege Bremen and Stuttgarter Intensivkongress.

8 Feb 2017

New research shows that nuts can inhibit growth of cancer cells

Roasted and salted, ground as a baking ingredient or fresh from the shell - for all those who enjoy eating nuts, there is good news from nutritionists at Friedrich Schiller University Jena.

6 Feb 2017

Single Molecule Detection of Proteins in Single Cells

We developed this technology almost 10 years ago. It was developed after a key experiment was carried out by David Rissin, who was a PhD candidate in my laboratory at the time.

From Pittcon 3 Feb 2017

Habitual e-cigarette use may be linked to long-term cardiac risks, study finds

A study published in JAMA Cardiology has added to growing evidence that electronic cigarettes (e-cigarettes) are not harmless.

1 Feb 2017

NMR and metabolic phenotyping

In this interview, Dr Harmut Schafer introduces the work being done at the Phenome Center in Birmingham, on metabolic phenotyping using NMR.

From Bruker BioSpin Division 31 Jan 2017

Scientists synthesize and evaluate mono/di-halogenated coumarins for anticancer activity

Throughout the world, many medicinal compounds are being discovered. Scientists have learnt to modify the chemical structures of active compounds so that they can improved therapeutic activity and reduced the toxicity.

30 Jan 2017

Timing of chemotherapy can have big effect on inflammation, study shows

The time of day that breast cancer chemotherapy drugs are given affects the amount of damaging inflammation in the body, a new study in mice suggests.

24 Jan 2017

Characterizing the Brain - Cell by Cell

My group develops approaches to study cell-to-cell signaling in the brain – how the cells of the brain talk to each other. The brain is heterogeneous, probably more so than any other organ in our body, and many of its functions depend on the unique characteristics of these cells.

From Pittcon 23 Jan 2017

Metabolites News and Research

Study reveals intriguing crosstalk between metabolism and epigenetics in cancer development

Fat cells take over production of uridine from liver during fasting

First physiological test opens door to early diagnosis of autism

Researchers probe potential link between gut microbiota and poor artery health

Decoding the Exposome Through Breath Biomarkers

Researchers develop new tool that quickly reveals metabolic fluxes in cells

Duke Health scientists identify proteins in mucous that confirm viral infection

Discovery of early biomarkers paves way for new insight into Huntington's disease

Melanoma patients' immunotherapy response linked to diversity and makeup of gut bacteria

UofL researcher receives NIH grant to study microbes responsible for protecting against malaria

Caffeine cannot prevent memory deficits linked to alcohol consumption, study finds

Mice study provides clues to how genetic variations in gut microbes influence metabolic disease

Instrument for blood gas and glucose analysis launched by Sphere Medical

New research shows that nuts can inhibit growth of cancer cells

Single Molecule Detection of Proteins in Single Cells

Habitual e-cigarette use may be linked to long-term cardiac risks, study finds

NMR and metabolic phenotyping

Scientists synthesize and evaluate mono/di-halogenated coumarins for anticancer activity

Timing of chemotherapy can have big effect on inflammation, study shows

Characterizing the Brain - Cell by Cell

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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