Metabolites News and Research

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Study shows metabolite concentration can be controlled in bioreactors using OPC enabled BioProfile FLEX analyser

Current initiatives within the biopharmaceutical industry to adopt PAT (Process Analytical Technology) approaches in manufacturing, include activities in early process development.

31 Oct 2016

Omega-3 fatty acids could promote clearance of metabolites in the brain, research shows

New research published online in The FASEB Journal suggests that omega-3 polyunsaturated fatty acids, which are found in fish oil, could improve the function of the glymphatic system, which facilitates the clearance of waste from the brain, and promote the clearance of metabolites including amyloid-β peptides, a primary culprit in Alzheimer's disease.

26 Oct 2016

WSU researchers identify potential new diagnostic tool for early detection of colorectal cancer

Scientists at Washington State University and Johns Hopkins Medical School have discovered a fast, noninvasive method that could lead to the early diagnosis of colorectal cancer.

25 Oct 2016

Benefit and harm of tandem mass spectrometry screening for tyrosinaemia type 1 remain unclear

Tyrosinaemia type 1 is a rare, hereditary metabolic disease that, if left untreated, can already lead to serious liver and kidney damage in infancy.

25 Oct 2016

Choline deficiency in sows during pregnancy impacts nutrient composition of milk

Choline is an essential nutrient that is used by the body in a number of ways. However, nearly 90 percent of adults do not get the recommended amount in their diets.

24 Oct 2016

Gut microbes can modify our mood and behaviour, research reveals

If aliens were to examine a human, they would think we were just slavish organisms designed to feed microbes and carry them around.

21 Oct 2016

Mount Sinai awarded $10 million grant to explore cellular, molecular mechanisms of GVHD

Researchers from the Icahn School of Medicine at Mount Sinai have been awarded a $10 million from the National Cancer Institute to explore the cellular and molecular mechanisms of acute graft-versus-host disease (GVHD), a common side effect that occurs after allogeneic bone marrow transplantation (BMT), and to develop novel therapeutic strategies for BMT patients with cancer that begin in the cells of blood-forming tissue or hematologic malignancies.

13 Oct 2016

Research findings provide new avenues to target virus infection

Viral infection is one of the leading medical challenges of the 21st Century, ranging from the Hepatitis C Virus (HCV) epidemic affecting 3% of the global population, to recent outbreaks of West Nile, Zika, and Ebola viruses.

12 Oct 2016

New non-invasive method could improve diagnosis of severe liver disease

A new non-invasive method of predicting the risk of developing a severe form of liver disease could ensure patients receive early and potentially life-saving medical intervention before irreversible damage is done.

6 Oct 2016

New lab-on-a-chip system can detect effects of toxic substances on hemoglobin in blood

A new lab-on-a-chip system, developed by the University of Twente in The Netherlands, is capable of fast analysis of the effects of toxic substances on hemoglobin, for example. It mimicks human metabolism.

4 Oct 2016

Maternal serum levels of nicotinamide linked to child’s risk of atopic eczema

Infants whose mothers had a higher level of a particular type of vitamin B during pregnancy have a lower risk of eczema at age 12 months, new Southampton research has shown.

23 Sep 2016

Crick researchers find promising target for new tuberculosis drugs

Scientists led by Dr Luiz Pedro Carvalho at the Francis Crick Institute in London have found a promising new target in the search for new tuberculosis drugs. In the process, they say they've proven the strengths of a new research technique called metabolomics.

20 Sep 2016

Oral antidiabetic drug modulates the body's nitrogen and urea metabolism

The most frequently prescribed oral antidiabetic drug metformin significantly affects metabolic pathways.

14 Sep 2016

Novel controlled clinical trial finds Ayurvedic-based well-being program can alter blood-based metabolites

In a novel controlled clinical trial, participants in a six-day Ayurvedic-based well-being program that featured a vegetarian diet, meditation, yoga and massages experienced measurable decreases in a set of blood-based metabolites associated with inflammation, cardiovascular disease risk and cholesterol regulation.

9 Sep 2016

Researchers describe how genetic mutations cause unnamed neurological disorder

In rare cases -- for instance, among siblings in two families from Pakistan and Oman described in a new study -- children have been born with an unnamed neurological disorder.

6 Sep 2016

ToMMo scientists identify genetic variants affecting enzymatic activities in healthy people

Scientists from Tohoku University's Tohoku Medical Megabank Organization have published research about genetic diversity and metabolome in Scientific Reports.

1 Sep 2016

Foul smelling gas could help people with diabetes recover from heart complications

A gas that was formerly known for its noxious qualities could help people with diabetes recover from common heart and blood vessel complications, concludes research led by the University of Exeter Medical School.

1 Sep 2016

UTHealth scientists discover powerful predictors of congestive heart failure

A team of scientists at The University of Texas Health Science Center at Houston and Baylor College of Medicine, led by Eric Boerwinkle, Ph.D., Richard Gibbs, Ph.D., and Bing Yu, Ph.D., have identified powerful predictors of congestive heart failure, a major cause of hospitalization and death in the United States.

31 Aug 2016

Whitehead Institute scientists develop novel method for profiling mitochondrial metabolites

Whitehead Institute scientists have developed a method to quickly isolate and systematically measure metabolite concentrations within the cellular organelles known as mitochondria, often referred to as the "powerhouses of the cell."